Combination of α-Glycosyl-Isoquercitrin and Soybean Fiber Promotes Quercetin Bioavailability and Glucagon-like Peptide-1 Secretion and Improves Glucose Homeostasis in Rats Fed a High-Fat High-Sucrose Diet

Abstract

This study examined the effects of a combination of soybean fiber and α-glycosyl-isoquercitrin (AGIQ) on improving quercetin bioavailability and glucose metabolism in rats fed an obesogenic diet. For 9 weeks, rats were individually fed a control diet, a high-fat high-sucrose (H) diet, H with soybean fiber (HS), or with AGIQ (HQ), or with both (HSQ). Quercetin derivatives in plasma, feces, urine, and cecal content were quantified by high-performance liquid chromatography to assess the bioavailability of quercetin, and meal tolerance tests were performed to assess postprandial glycemia and glucagon-like peptide-1 (GLP-1) responses. The HSQ group had higher plasma quercetin levels than HQ. The postprandial glycemia was attenuated in the HSQ group when compared to the H group. The basal plasma GLP-1 concentrations positively correlated with plasma quercetin derivative concentrations. Hence, the combination of soybean fiber and AGIQ could be beneficial for reducing the risk of glucose intolerance, possibly involving enhanced quercetin bioavailability and GLP-1 secretion.

Nutraceutical Eriocitrin (Eriomin) Reduces Hyperglycemia by Increasing Glucagon-Like Peptide 1 and Downregulates Systemic Inflammation: A Crossover-Randomized Clinical Trial

“… 7 Among them, quercetin, genistein, and citrus flavonoids, such as hesperidin and eriocitrin, have been studied. 8–13 …”

Polyphenol from Rosaroxburghii Tratt Fruit Ameliorates the Symptoms of Diabetes by Activating the P13K/AKT Insulin Pathway in db/db Mice

“…Kun Dai et al demonstrated that chlorogenic acid in peaches has significant antioxidant and hypoglycemic effects, which could inhibit α-glucosidase, α-amylase and scavenges free radical [ 14 ]. Aphichat et al discovered that quercetin could improve glucose metabolism and glucose tolerance [ 15 ]. Yin et al revealed that ellagic acid-rich oak extracts notably reduced serum MDA and SOD and inhibited α-glucosidase and α-amylase activities in diabetic mice [ 16 ].…”

Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer

“…Another study in rats fed a high-fat high-sucrose diet has shown that the combination of a glycosylated quercetin derivative and soyabean fiber prevented dietary glucose intolerance and was accompanied by an increase in plasma GLP-1 levels. In addition, GLP-1 levels were positively correlated with quercetin concentrations in plasma, thereby demonstrating the effect of soybean fiber and quercetin on reducing the risk of glucose intolerance and imbedding diabetes [ 45 ].…”

“…Quercetin can be a powerful antioxidant by creating complexes after taking into account its chemical properties related to its high solubility and bioavailability [ 42 , 43 , 44 ]. Its action against diabetes is explained by its effect on hepatic HepG2 cells, where it alleviates oxidative stress due to hyperglycemia, and activation of the Nrf2 metabolic pathway in pancreatic tissue [ 45 , 46 ]. Moreover, in the clinical field, Rauf et al [ 47 ] stressed that quercetin is both an inhibitory and a preventive agent for cancer, and can assist treatments against the disease, such as chemotherapy.…”