Combination of zinc and selenium alleviates ochratoxin A-induced fibrosis via blocking ROS-dependent autophagy in HK-2 cells

Le, Guannan; Du, Heng; Hou, Lili; Liu, Ge; Sylia, Ardache; Muhmood, Azhar; Chen, Xinxiang; Han, Bo; Huang, Kehe

doi:10.1016/j.jtemb.2021.126881

Cited by 10 publications

(8 citation statements)

References 27 publications

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“…In another DN model, Zn had an important anti-fibrosis role, and a novel mechanism was identified that contributed to Zn protection on renal tubular epithelial cells from high glucose/hypoxiainduced epithelial-to-mesenchymal transition through activation of the PI3K/Akt/GSK-3β signaling pathway, which subsequently leads to the downregulation of the expression of HIF-1α (95). A recent study observed the combination of Zn and Se reduced the cytotoxicity and fibrosis of Ochratoxin A-induced human renal proximal tubule epithelial cells (96), while many Zn binding proteins (such as matrix metalloproteinases, snail family Zn finger 1, and ZAG) play an anti-fibrosis role in CKD (97)(98)(99).…”

Section: Zn and Renal Fibrosismentioning

confidence: 99%

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Xie¹,

Liu²,

Zhang³

et al. 2022

Ann Transl Med

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Background and Objective: Chronic kidney disease (CKD) is an important public health concern.With the decline of renal function, CKD patients gradually progress to end-stage kidney disease and need to undergo dialysis or kidney transplantation to maintain life, bringing a heavy economic burden to the family and society. Therefore, it is necessary to effectively prevent and delay the progression of CKD. Essential trace elements play an indispensable role in CKD, and the objective of this study is to systematically review their benefits in the disease and summarize the risks of their excess.Methods: The keywords "trace elements", "chronic kidney disease", "dialysis", "inflammation", and "fibrosis" and their combinations were used to search for relevant literature published in the PubMed database and Web of Science. We then summarized the role of trace element abnormalities in CKD patients in anemia, oxidative stress, inflammation, and chronic fibrosis, and the risk of their excess.

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Section: Zn and Renal Fibrosismentioning

confidence: 99%

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Xie¹,

Liu²,

Zhang³

et al. 2022

Ann Transl Med

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“…Recent studies have reported that OTA could induce oxidative stress in a variety of different cellular and tissue models [19,[30][31][32][33][34][35]. It has been reported that OTAinduced oxidative stress [19,31,32], and Curcumin could relieve OTA-induced hepatotoxicity and nephrotoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…Fibrosis is also an important manifestation of organ aging [19]. Masson staining showed that the bronchial branches of the lung in the control group were relatively normal with no alveolar wall or bronchial wall fibrosis evident, nor was obvious damage to the lung tissue structure observed.…”

Section: The Effect Of Ota On Lung Fibrosismentioning

confidence: 97%

Dietary Ochratoxin A Contamination Modulates Oxidative Stress, Inflammation Processes and Causes Fibrosis in in vitro and in vivo Lung Models

Ou¹,

Fu²,

Chen³

et al. 2023

Front. Biosci. (Landmark Ed)

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Background:The prevalence of aging-related diseases has increased significantly and this imposes a burden on both families and society. The lung is one of the few internal organs that is continuously exposed to the external environment, and lung aging is associated with a number of lung diseases. Ochratoxin A (OTA) is a toxin that is widely present in food and the environment but an effect for OTA on lung aging has not been reported. Methods: Using both cultured lung cell and in vivo model systems, we studied the effect of OTA on lung cell senescence using flow cytometry, indirect immunofluorescence, western blotting, and immunohistochemistry. Results: Results obtained showed that OTA caused significant lung cell senescence in cultured cells. Furthermore, using in vivo models, results showed that OTA caused lung aging and aging fibrosis. Mechanistic analysis showed that OTA upregulated the levels of inflammation and oxidative stress, and that this may be the molecular basis of OTA-induced lung aging. Conclusions: Taken together, these findings indicate that OTA causes significant aging damage to the lung, which lays an important foundation for the prevention and treatment of lung aging.

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“…In this respect, the effect of the combination of zinc and Se on OTA-induced fibrosis in the human renal proximal tubule epithelial (HK-2) cell line has been studied. According to data, both exerted a synergistic protective activity, which was associated with the inhibition of the ROS-dependent autophagy in these cells [284]. Moreover, the SeMet protective effect on the cytotoxicity and pyroptosis of Madin-Darby canine kidney (MDCK) cells induced by OTA has been demonstrated.…”

Section: Selenomethionine and Kidney Diseasesmentioning

confidence: 95%

Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?

et al. 2022

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Selenium (Se) is an essential element for human health as it is involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents in the prevention and treatment of some diseases. It is widely recognized that Se activity is related to multiple factors, such as its chemical form, dose, and its metabolism. The understanding of its complex biochemistry is necessary as it has been demonstrated that the metabolites of the Se molecules used to be the ones that exert the biological activity. Therefore, the aim of this review is to summarize the recent information about its most remarkable metabolites of acknowledged biological effects: hydrogen selenide (HSe−/H2Se) and methylselenol (CH3SeH). In addition, special attention is paid to the main seleno-containing precursors of these derivatives and their role in different pathologies.

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Combination of zinc and selenium alleviates ochratoxin A-induced fibrosis via blocking ROS-dependent autophagy in HK-2 cells

Cited by 10 publications

References 27 publications

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Dietary Ochratoxin A Contamination Modulates Oxidative Stress, Inflammation Processes and Causes Fibrosis in in vitro and in vivo Lung Models

Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?

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