Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-κB and activates Nrf2 in pancreatic cancer cells

Krajka‐Kuźniak, Violetta; Cykowiak, Marta; Szaefer, Hanna; Kleszcz, Robert; Baer‐Dubowska, Wanda

doi:10.1016/j.tiv.2020.104799

Cited by 36 publications

(31 citation statements)

References 23 publications

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“…Hyperoside also decrease the productions of inflammatory cytokines, down regulates the expression of MMPs and ADAMTS-5, and mediates the activity of NF-κB/MAPK and NRF2/HO-1 signaling pathways ( Sun et al, 2021 ). XH is a prenylated chalcone isolated from the hop plant and shows anti-inflammatory, anti-oxidative, anti-proliferative, and anti-angiogenic activity ( Harikumar et al, 2009 ; Krajka-Kuźniak et al, 2020 ). Consistently, our study showed that XH could decrease the productions of the inflammation cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…Consistently, our study showed that XH could decrease the productions of the inflammation cytokines. Interestingly, XH has also been an activator of NRF2/HO-1 signaling ( Bai et al, 2019 ; Krajka-Kuźniak et al, 2020 ). XH exhibits free radicals scavenging activity by activating NRF2/HO-1 signaling, preventing neuro-degeneration ( Wang et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

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Xanthohumol Attenuated Inflammation and ECM Degradation by Mediating HO-1/C/EBPβ Pathway in Osteoarthritis Chondrocytes

Zhang

Zheng

et al. 2021

Front. Pharmacol.

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Osteoarthritis (OA) is the most frequent and disabling disease in developed countries. The progressive degeneration of articular cartilage characterized as thinner and erosive. Inflammation is well-known to be involved in OA development. However, there are no effective therapeutic strategies to cure it. Xanthohumol (XH) is a natural prenylflavonoid isolated from hops and beer. The protective activity of XH against OA chondrocytes inflammation and ECM degradation is unclear. In this article, we found that XH significantly inhibited inflammatory responses, attenuated catabolic enzymes expression, and ameliorated ECM degradation, as showed by decreased production of NO, PGE2, TNFα, and IL-6, decreased expression of MMP-3/-13 and ADAMTS-4/-5, and increased expression of collagen-II and aggrecan. In addition, XH activated HO-1 signaling and attenuated IL-1β-induced C/EBPβ. XH promoted the interaction between HO-1 and C/EBPβ, inhibiting the nuclear translocation of C/EBPβ. HO-1 knockdown could abrogate the protective effects of XH in IL-1β-treated chondrocytes. Collectively, XH attenuated inflammatory responses and ECM degradation by mediating HO-1 and C/EBPβ signaling pathways in osteoarthritis chondrocytes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Xanthohumol Attenuated Inflammation and ECM Degradation by Mediating HO-1/C/EBPβ Pathway in Osteoarthritis Chondrocytes

Zhang

Zheng

et al. 2021

Front. Pharmacol.

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“…XH in combination with phenethyl isothiocyanate reduced the proliferation of PANC-1 cells. XH and phenethyl isothiocyanate, in combination, reduced NF-κB activity and enhanced Nrf2 expression and expression of Nrf2-related genes (SOD, NQO1, and GSTP) in pancreatic cancer cells [ 18 ].…”

Section: Anticancer Potential Of Xh Based On Preclinical Evidencementioning

confidence: 99%

“…However, Magalhaes et al [ 4 ] reviewed the production of XH-enriched beer and its antioxidant, cardioprotective, anti-inflammatory, antiproliferative, cancer chemopreventive, and broad spectrum anti-infective effects. XH mixed with phenethyl isothiocyanate activated Nrf2 and inhibited nuclear factor-κB (NF-κB) in pancreatic cells [ 18 ]. Another study by Lin et al [ 19 ] performed various in vitro and in vivo experiments using XH in the context of several chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets

Harish

Haque

Śmiech

et al. 2021

IJMS

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Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure–activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers.

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“…In light of this, much attention was directed toward using plant derivednatural compounds as potential anti-tumor agents for use in combination chemotherapy, and for suppressing malignant behavior and the proliferation of cancer cells (Abotaleb et al, 2020;Liskova et al, 2020;Varghese et al, 2020). In respect to the fact that a variety of molecular pathways are involved in the progression and proliferation of PC cells such as Wnt (Xu et al, 2020), Nrf 2 (Krajka-Kuzniak et al, 2020), long non-coding RNAs (lncRNAs) (Yin et al, 2020), and microRNAs (miRs) (Wang et al, 2020) its effective therapy relies on using anti-tumor compounds with the capability of the induction of onco-suppressor pathways, and the inhibition of oncogene ones. Notably, naturally occurring compounds are capable of modulating molecular pathways and mechanisms.…”

Section: Introduction Pancreatic Cancer: a Brief Representationmentioning

confidence: 99%

Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

et al. 2020

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Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract. Due to its propensity for early local and distant spread, affected patients possess extremely poor prognosis. Currently applied treatments are not effective enough to eradicate all cancer cells, and minimize their migration. Besides, these treatments are associated with adverse effects on normal cells and organs. These therapies are not able to increase the overall survival rate of patients; hence, finding novel adjuvants or alternatives is so essential. Up to now, medicinal herbs were utilized for therapeutic goals. Herbal-based medicine, as traditional biotherapeutics, were employed for cancer treatment. Of them, apigenin, as a bioactive flavonoid that possesses numerous biological properties (e.g., anti-inflammatory and anti-oxidant effects), has shown substantial anticancer activity. It seems that apigenin is capable of suppressing the proliferation of cancer cells via the induction of cell cycle arrest and apoptosis. Besides, apigenin inhibits metastasis via down-regulation of matrix metalloproteinases and the Akt signaling pathway. In pancreatic cancer cells, apigenin sensitizes cells in chemotherapy, and affects molecular pathways such as the hypoxia inducible factor (HIF), vascular endothelial growth factor (VEGF), and glucose transporter-1 (GLUT-1). Herein, the biotherapeutic activity of apigenin and its mechanisms toward cancer cells are presented in the current review to shed some light on anti-tumor activity of apigenin in different cancers, with an emphasis on pancreatic cancer.

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Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-κB and activates Nrf2 in pancreatic cancer cells

Cited by 36 publications

References 23 publications

Xanthohumol Attenuated Inflammation and ECM Degradation by Mediating HO-1/C/EBPβ Pathway in Osteoarthritis Chondrocytes

Xanthohumol Attenuated Inflammation and ECM Degradation by Mediating HO-1/C/EBPβ Pathway in Osteoarthritis Chondrocytes

Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets

Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

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