Combination of Urinary MiR-501 and MiR-335 With Current Clinical Diagnostic Parameters as Potential Predictive Factors of Prostate Biopsy Outcome

Juráček, Jaroslav; Mądrzyk, Marie; Trachtová, Karolína; Ruckova, Michaela; Bohošová, Júlia; Barth, Dominik A.; Pichler, Martin; Staník, Michal; Slabý, Ondřej

doi:10.21873/cgp.20383

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Our 9-miRNA signature does not contain any of the 7 miRNAs identified by Sathipati et al This divergence is attributable to the substantially different methodologies of the two studies. Interestingly 3 out of 5 HCC-specific upregulated miRNAs have been measured in biological fluids from cancer patients [ 36 – 38 ]. This result suggests the potential clinical relevance of our miRNA signature to guide clinical diagnosis and prognosis.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of differentially expressed miRNAs in hepatocellular carcinoma: Prognostic, predictive significance and pathway insights

Smith,

Beach,

Silva

et al. 2024

PLoS ONE

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Robust prognostic and predictive factors for hepatocellular carcinoma, a leading cause of cancer-related deaths worldwide, have not yet been identified. Previous studies have identified potential HCC determinants such as genetic mutations, epigenetic alterations, and pathway dysregulation. However, the clinical significance of these molecular alterations remains elusive. MicroRNAs are major regulators of protein expression. MiRNA functions are frequently altered in cancer. In this study, we aimed to explore the prognostic value of differentially expressed miRNAs in HCC, to elucidate their associated pathways and their impact on treatment response. To this aim, bioinformatics techniques and clinical dataset analyses were employed to identify differentially expressed miRNAs in HCC compared to normal hepatic tissue. We validated known associations and identified a novel miRNA signature with potential prognostic significance. Our comprehensive analysis identified new miRNA-targeted pathways and showed that some of these protein coding genes predict HCC patients’ response to the tyrosine kinase inhibitor sorafenib.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of differentially expressed miRNAs in hepatocellular carcinoma: Prognostic, predictive significance and pathway insights

Smith,

Beach,

Silva

et al. 2024

PLoS ONE

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Diagnostic properties of miR-146a-5p from liquid biopsies in prostate cancer: A meta-analysis

Dobrijević,

Stevanović,

Šunderić

et al. 2024

Pathology - Research and Practice

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MicroRNA´S COMO BIOMARCADORES DO CÂNCER DE PRÓSTATA: UMA REVISÃO INTEGRATIVA

Telis,

Pimenta,

Teixeira

et al. 2023

Rev. Foco

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MicroRNA é um constituinte do genoma não-codificante capaz de regular a síntese proteica em nível pós-transcricional, silenciando ou induzindo a degradação de RNA mensageiros. A expressão de microRNA é basal em todos os tipos celulares, ao passo que o perfil de expressão é particular a cada um. O conjunto de microRNAs produzidos em uma célula se torna uma característica exclusiva a ela, de acordo com suas próprias funções metabólicas. Investigações dos mecanismos moleculares do câncer revelaram que o miRNA desempenha um papel importante nesta doença, estando pontualmente desregulado e tendo uma participação direta na mediação de processos de invasão tecidual e divisão celular. A presente revisão investigou os microRNAs no câncer de próstata (CaP) a partir de trabalhos da literatura, com o intuito de formar um painel de biomarcadores para o diagnóstico mais precoce da doença. Trata-se de um estudo do tipo revisão integrativa na qual foram utilizadas as bases de dados: U.S National Library of Medicine (PUBMED), Scientific Eletronic Library Online (SciELO) e Google Acadêmico. Os descritores utilizados foram “Prostatic Neoplasms” e “microRNA”, associados ao operador boleano AND, visando a resposta da seguinte pergunta norteadora: Quais microRNA´s são potenciais biomarcadores do CaP? Notou-se que a heterogeneidade do tumor pode estar atrelada a falta de evidências para a maioria dos microRNAs investigados e que o microRNA (miR-21) apresenta potencial para biomarcador do CaP.

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Combination of Urinary MiR-501 and MiR-335 With Current Clinical Diagnostic Parameters as Potential Predictive Factors of Prostate Biopsy Outcome

Abstract: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Cited by 3 publications

References 16 publications

Comprehensive analysis of differentially expressed miRNAs in hepatocellular carcinoma: Prognostic, predictive significance and pathway insights

Comprehensive analysis of differentially expressed miRNAs in hepatocellular carcinoma: Prognostic, predictive significance and pathway insights

Diagnostic properties of miR-146a-5p from liquid biopsies in prostate cancer: A meta-analysis

MicroRNA´S COMO BIOMARCADORES DO CÂNCER DE PRÓSTATA: UMA REVISÃO INTEGRATIVA

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