Combination of TiO2 nanoparticles and Echinometra mathaeis gonad extracts: In vitro and in vivo scolicidal activity against hydatid cysts

Navvabi, Azita; Homaei, Ahmad; Khademvatan, Shahram; Ansari, Mohammad Hassan Khadem; Keshavarz, Mousa

doi:10.1016/j.bcab.2019.101432

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Their results showed that sea urchin gonad extract at the concentration 15 μg/mL, especially in combination with TiO2, killed 84% of the protoscoleces after 60 min exposure in vitro. On the other hand, oral administration of infected mice with the combination of the gonad extract + TiO2 for three months demonstrated higher efficacy by reduction in number, size and volume of the hydatid cysts in comparison to the control group [ 29 ] . …”

Section: Discussionmentioning

confidence: 99%

High Potency of Organic and Inorganic Nanoparticles to Treat Cystic Echinococcosis: An Evidence-Based Review

et al. 2020

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Since there is no potential, effective vaccine available, treatment is the only controlling option against hydatid cyst or cystic echinococcosis (CE). This study was designed to systematically review the in vitro, in vivo, and ex vivo effects of nanoparticles against hydatid cyst. The study was carried out based on the 06- PRISMA guideline and registered in the CAMARADES-NC3Rs Preclinical Systematic Review and Meta-analysis Facility (SyRF) database. The search was performed in five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar without time limitation for publications around the world about the protoscolicdal effects of all the organic and inorganic nanoparticles without date limitation in order to identify all the published articles (in vitro, in vivo, and ex vivo). The searched words and terms were: “nanoparticles”, “hydatid cyst”, “protoscoleces”, “cystic echinococcosis”, “metal nanoparticles”, “organic nanoparticles”, “inorganic nanoparticles, “in vitro”, ex vivo”, “in vivo”. Out of 925 papers, 29 papers including 15 in vitro (51.7%), 6 in vivo (20.7%), ex vivo 2 (6.9%), and 6 in vitro/in vivo (20.7%) up to 2020 met the inclusion criteria for discussion in this systematic review. The results demonstrated the most widely used nanoparticles in the studies were metal nanoparticles such as selenium, silver, gold, zinc, copper, iron nanoparticles (n = 8, 28.6%), and metal oxide nanoparticles such as zinc oxide, titanium dioxide, cerium oxide, zirconium dioxide, and silicon dioxide (n = 8, 28.6%), followed by polymeric nanoparticles such as chitosan and chitosan-based nanoparticles (n = 7, 25.0%). The results of this review showed the high efficacy of a wide range of organic and inorganic NPs against CE, indicating that nanoparticles could be considered as an alternative and complementary resource for CE treatment. The results demonstrated that the most widely used nanoparticles for hydatid cyst treatment were metal nanoparticles and metal oxide nanoparticles, followed by polymeric nanoparticles. We found that the most compatible drugs with nanoparticles were albendazole, followed by praziquantel and flubendazole, indicating a deeper understanding about the synergistic effects of nanoparticles and the present anti-parasitic drugs for treating hydatid cysts. The important point about using these nanoparticles is their toxicity; therefore, cytotoxicity as well as acute and chronic toxicities of these nanoparticles should be considered in particular. As a limitation, in the present study, although most of the studies have been performed in vitro, more studies are needed to confirm the effect of these nanoparticles as well as their exact mechanisms in the hydatid cyst treatment, especially in animal models and clinical settings.

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Section: Discussionmentioning

confidence: 99%

High Potency of Organic and Inorganic Nanoparticles to Treat Cystic Echinococcosis: An Evidence-Based Review

et al. 2020

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“…The killing rate was 100% at the concentration of 500 mg/ml of nanoparticles (Aljanabi et al 2021). In a recent study, Navvabi et al (2019) indicated that the scolicidal effect was 84% when gonad extract of sea urchin was used in combination with titanium dioxide at 15 µg/ml concentration for 60 minutes exposure time in vitro. When gonad extract and titanium dioxide nanoparticles were given orally in infected mice for three months, significant reductions in size, volume and weight of hydatid cysts were observed.…”

Section: Nano Particlesmentioning

confidence: 99%

Introduction To Echinococcosis and A Review of Treatment Panels

2021

Int J Vet Sci

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“…Nanomaterials are atomic or molecular assemblies with minimum dimensions between 1 and 100 nm, which have different physical and chemical properties compared to the bulk mass of the material. Common examples are silver, zinc oxide, copper oxide, and magnetic iron nanoparticles 29–33 …”

Section: Introductionmentioning

confidence: 99%

“…Common examples are silver, zinc oxide, copper oxide, and magnetic iron nanoparticles. [29][30][31][32][33] Due to their unique properties, silver nanoparticles are broadly applied in the medicinal industry and exert catalytic, antibacterial, anti-inflammatory, and electromagnetic properties. 34,35 The present study aimed to assess the effect of biological compounds of H. parva and silver nanoparticles on the activity of α-amylase to show their in vitro antidiabetic activities.…”

Section: Introductionmentioning

confidence: 99%

Exploring in vitro effect of silver nanoparticles and Holothuria parva extracts on kinetics and stability of α‐amylase

Edrispour

Homaei

2022

Biotech and App Biochem

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Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels. Major limitations of synthetic drugs, including high cost, efficacy, and adverse side effects, have prompted researchers to seek more effective and low‐cost alternative therapies with fewer adverse effects. Marine life forms are considered the most important sources of biologically active natural products due to their secondary metabolites. In this research, sea cucumber Holothuria parva was collected from coastal areas of Bandar Lengeh, Hormozgan, Iran, and was then subjected to extraction. The results showed that compounds extracted from Holothuria parva had a stimulatory effect on enzyme activity, and in the presence of these compounds, the Vmax value of the enzyme was increased about two times, while the Km value was reduced. The phosphate buffer form of extracts had the greatest impact on enzyme activity. Upon an increase in the concentration of silver nanoparticles (AgNPs), the α‐amylase activity was inhibited in parallel. Silver nanoparticles exhibited the highest enzyme inhibition with an IC50 of 0.86 mg/ml. Silver nanoparticles showed anti‐α‐amylase activity and had the ability to decrease intestinal glucose uptake in diabetic individuals when prescribed as a novel supplementary medicine.

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Combination of TiO2 nanoparticles and Echinometra mathaeis gonad extracts: In vitro and in vivo scolicidal activity against hydatid cysts

Cited by 7 publications

References 17 publications

High Potency of Organic and Inorganic Nanoparticles to Treat Cystic Echinococcosis: An Evidence-Based Review

High Potency of Organic and Inorganic Nanoparticles to Treat Cystic Echinococcosis: An Evidence-Based Review

Introduction To Echinococcosis and A Review of Treatment Panels

Exploring in vitro effect of silver nanoparticles and Holothuria parva extracts on kinetics and stability of α‐amylase

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