Combination of the non-invasive tests for the diagnosis of endometriosis

Nisenblat, Vicki; Prentice, Lucy; Bossuyt, Patrick M.; Farquhar, Cindy; Hull, Louise; Johnson, Neil

doi:10.1002/14651858.cd012281

Cited by 130 publications

(151 citation statements)

References 89 publications

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“…Consequently, its effective treatment still remains a challenge . So far the quest for novel nonhormonal therapeutics has not been successful, and there is no single biomarker that has unequivocally been shown to be clinically useful in diagnosing endometriosis …”

Section: Introductionmentioning

confidence: 99%

Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis

Guo

2018

Reprod Medicine & Biology

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BackgroundOne recent study reports cancer driver mutations in deep endometriosis, but its biological/clinical significance remains unclear. Since the natural history of endometriosis is essentially gradual progression toward fibrosis, it is thus hypothesized that the six driver genes reported to be mutated in endometriosis (the RP set) may play important roles in fibrogenesis but not necessarily malignant transformation.MethodsExtensive PubMed search to see whether RP and another set of driver genes not yet reported (NR) to be mutated in endometriosis have any roles in fibrogenesis. All studies reporting on the role of fibrogenesis of the genes in both RP and NR sets were retrieved and evaluated in this review.ResultsAll six RP genes were involved in various aspects of fibrogenesis as compared with only three NR genes. These nine genes can be anchored in networks linking with their upstream and downstream genes that are known to be aberrantly expressed in endometriosis, piecing together seemingly unrelated findings.ConclusionsGiven that somatic driver mutations can and do occur frequently in physiologically normal tissues, it is argued that these mutations in endometriosis are not necessarily synonymous with malignancy or premalignancy, but the result of enormous pressure for fibrogenesis.

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Section: Introductionmentioning

confidence: 99%

Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis

Guo

2018

Reprod Medicine & Biology

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“…Endometriotic lesions may occur at various anatomic sites, including the pelvic peritoneum and the ovary [2]. Deep-infiltrating endometriosis occurs in the pelvic structures below the surface of the peritoneum.…”

Section: Introductionmentioning

confidence: 99%

Patient-completed or symptom-based screening tools for endometriosis: a scoping review

Surrey

Carter

Soliman

et al. 2017

Arch Gynecol Obstet

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PurposeThe objective of this review was to evaluate existing patient-completed screening questionnaires and/or symptom-based predictive models with respect to their potential for use as screening tools for endometriosis in adult women. Validated instruments were of particular interest.MethodsWe conducted structured searches of PubMed and targeted searches of the gray literature to identify studies reporting on screening instruments used in endometriosis. Studies were screened according to inclusion and exclusion criteria that followed the PICOS (population, intervention, comparison, outcomes, study design) framework.ResultsA total of 16 studies were identified, of which 10 described measures for endometriosis in general, 2 described measures for endometriosis at specific sites, and 4 described measures for deep-infiltrating endometriosis. Only 1 study evaluated a questionnaire that was solely patient-completed. Most measures required physician, imaging, or laboratory assessments in addition to patient-completed questionnaires, and several measures relied on complex scoring. Validation for use as a screening tool in adult women with potential endometriosis was lacking in all studies, as most studies focused on diagnosis versus screening.ConclusionsThis literature review did not identify any fully validated, symptom-based, patient-reported questionnaires for endometriosis screening in adult women.

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“…() and Nisenblat, Prentice, et al. (), 34 Nisenblat, Bossuyt, Farquhar, Johnson, and Hull et al. (), Nisenblat, Bossuyt, Shaikh, et al.…”

Section: Resultsmentioning

confidence: 99%

lilacs search strategy for systematic reviews of diagnostic test accuracy studies

Pereira

Puga

Atallah

et al. 2019

Health Info Libraries J

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Background There are few publications on search strategies to identify diagnostic test accuracy (DTA) studies in lilacs. Objective To translate and customise medline search strategies for use in lilacs and assess their retrieval of studies in Cochrane DTA systematic reviews. Method We developed a six‐step process to translate and customise medline search strategies for use in lilacs (iAHx interface). We identified medline search strategies of published Cochrane DTA reviews, translated/customised them for use in lilacs, ran searches in lilacs and compared the retrieval results of our translated search strategy versus the one used in the published reviews. Results Our lilacs search strategies translated/customised from the medline strategies retrieved studies in 70 Cochrane DTA reviews. Only 29 of these reviews stated that they had searched the lilacs database and 21 published their lilacs search strategies. Few had used the lilacs database search tools, none exploded the subject headings, and 86% used only English terms. Conclusion Translating and tailoring a medline search strategy for the lilacs database resulted in the retrieval of DTA studies that would have been missed otherwise.

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Combination of the non-invasive tests for the diagnosis of endometriosis

Cited by 130 publications

References 89 publications

Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis

Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis

Patient-completed or symptom-based screening tools for endometriosis: a scoping review

lilacs search strategy for systematic reviews of diagnostic test accuracy studies

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