Combination of the gut microbiota and clinical indicators as a potential index for differentiating idiopathic membranous nephropathy and minimal change disease

Jiang, Yumin; Wang, Ting; Yu, Wei; Wu, Feng; Guo, Renhua; Li, Huangmin; Zhang, Yiding; Ge, Yan; Wang, Li; Zhao, Zhanzheng

doi:10.1080/0886022x.2023.2209392

Cited by 3 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may be caused by intra-group differences in TIN (Tubulo-interstitial nephritis, not specified as acute or chronic), because the summary data we obtained failed to distinguish ATIN and TIN in the TIN group. In addition, the clinical manifestations of TIN with different causes will be different (46-49), and different types of nephritis will also have different pathological characteristics and clinical outcomes (50)(51)(52)(53). Therefore, compared with TIN, the conclusion that decreased Lp-PLA2 is a protective factor for ATIN is more reliable, while the conclusion that increased Lp-PLA2 is a protective factor for TIN needs to be treated with caution.…”

Section: Discussionmentioning

confidence: 99%

“…They highlighted specific alterations in fatty acid β-oxidation, the TCA cycle, glycolysis, and oxidative phosphorylation among these subtypes, findings consistent with those of Dong et al (71). The gut microbiome, proteomic and metabolomic landscape of renal diseases offers insights into pathogenesis, treatment, and prevention, yet transcriptomic studies remain scarce (50,(72)(73)(74)(75). Scientists are also promoting the discovery of new treatments and targets for various types of nephritis (76-79).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Causal association of plasma circulating metabolites with nephritis: a Mendelian randomization study

Shao,

Yao,

Weng

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

BackgroundNephritis is a pivotal catalyst in chronic kidney disease (CKD) progression. Although epidemiological studies have explored the impact of plasma circulating metabolites and drugs on nephritis, few have harnessed genetic methodologies to establish causal relationships.MethodsThrough Mendelian randomization (MR) in two substantial cohorts, spanning large sample sizes, we evaluated over 100 plasma circulating metabolites and 263 drugs to discern their causal effects on nephritis risk. The primary analytical tool was the inverse variance weighted (IVW) analysis. Our bioinformatic scrutiny of GSE115857 (IgA nephropathy, 86 samples) and GSE72326 (lupus nephritis, 238 samples) unveiled anomalies in lipid metabolism and immunological characteristics in nephritis. Thorough sensitivity analyses (MR-Egger, MR-PRESSO, leave-one-out analysis) were undertaken to verify the instrumental variables’ (IVs) assumptions.ResultsUnique lipoprotein-related molecules established causal links with diverse nephritis subtypes. Notably, docosahexaenoic acid (DHA) emerged as a protective factor for acute tubulointerstitial nephritis (ATIN) (OR1 = 0.84, [95% CI 0.78–0.90], p1 = 0.013; OR2 = 0.89, [95% CI 0.82–0.97], p2 = 0.007). Conversely, multivitamin supplementation minus minerals notably increased the risk of ATIN (OR = 31.25, [95% CI 9.23–105.85], p = 0.004). Reduced α-linolenic acid (ALA) levels due to lipid-lowering drugs were linked to both ATIN (OR = 4.88, [95% CI 3.52–6.77], p < 0.001) and tubulointerstitial nephritis (TIN) (OR = 7.52, [95% CI 2.78–20.30], p = 0.042). While the non-renal drug indivina showed promise for TIN treatment, the use of digoxin, hydroxocobalamin, and liothyronine elevated the risk of chronic tubulointerstitial nephritis (CTIN). Transcriptome analysis affirmed that anomalous lipid metabolism and immune infiltration are characteristic of IgA nephropathy and lupus nephritis. The robustness of these causal links was reinforced by sensitivity analyses and leave-one-out tests, indicating no signs of pleiotropy.ConclusionDyslipidemia significantly contributes to nephritis development. Strategies aimed at reducing plasma low-density lipoprotein levels or ALA supplementation may enhance the efficacy of existing lipid-lowering drug regimens for nephritis treatment. Renal functional status should also be judiciously considered with regard to the use of nonrenal medications.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Causal association of plasma circulating metabolites with nephritis: a Mendelian randomization study

Shao,

Yao,

Weng

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…These biomarkers were associated with increased amino acid metabolic pathways, carbohydrate metabolism and lipid metabolism in DKD patients, while increased interconversion of pentose/glucuronate and membrane transport in relation to adenosine triphosphate (ATP)‐binding cassette transporters and phosphotransferase system in patients with IMN (Yu et al, 2020). In addition, the latest study reported that a classifier of gut microbiota combined with clinical indexes showed good performance in identifying IMN and minimal change disease (Jiang et al, 2023). Therefore, these findings suggested that altered gut microbiota can distinguish IMN from other renal diseases.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus species ameliorate membranous nephropathy through inhibiting the aryl hydrocarbon receptor pathway via tryptophan‐produced indole metabolites

Miao,

Wang,

et al. 2023

British J Pharmacology

View full text Add to dashboard Cite

Background and PurposeMembranous nephropathy (MN) is an immune‐mediated glomerular disease among adults. Antibodies and antigens bonding mechanisms have been largely clarified, but few subepithelium immune complex deposition‐mediated underlying downstream molecular mechanisms are currently known. Increasing evidence has suggested that gut microbiota contributed to MN pathogenesis.Experimental ApproachIn this study, we identified alteration of faecal gut microbiota and serum metabolites that mediated aryl hydrocarbon receptor (AhR) mechanism in cationic bovine serum albumin (CBSA)‐induced MN rats and patients with IMN.Key ResultsWe found that impaired renal function correlated with relative abundances of reduced faecal probiotics Lactobacillus and Bifidobacterium and serum levels of altered tryptophan‐produced indole derivatives (TPID) in MN rats. Further results showed that reduced relative abundances of five probiotics including Lactobacillus johnsonii, Lactobacillus murinus, Lactobacillus vaginalis, Lactobacillus reuteri and Bifidobacterium animalis positively correlated with levels of decreased indole‐3‐pyruvic acid, indole‐3‐aldehyde and tryptamine, and negatively correlated with levels of increased indole‐3‐lactic acid and indole‐3‐acetic acid in serum of MN rats. Altered five probiotics and five TPID were also observed in patients with IMN. Further studies showed that MN rats exhibited a significant increase in intrarenal mRNA expressions of AhR and its target genes CYP1A1, CYP1A2 and CYP1B1, which was accompanied by protein expressions of downregulated cytoplasm AhR while upregulated nuclei AhR in MN rats and IMN patients.Conclusion and Implicationsctivation of intrarenal AhR signaling pathway might be mediated by five TPID. These data suggest that gut microbiota could influence MN through TPID engaging host receptors.

show abstract

Deciphering the gut microbiome: The revolution of artificial intelligence in microbiota analysis and intervention

Abavisani,

Khoshrou,

Foroushan

et al. 2024

Current Research in Biotechnology

View full text Add to dashboard Cite

Combination of the gut microbiota and clinical indicators as a potential index for differentiating idiopathic membranous nephropathy and minimal change disease

Cited by 3 publications

References 31 publications

Causal association of plasma circulating metabolites with nephritis: a Mendelian randomization study

Causal association of plasma circulating metabolites with nephritis: a Mendelian randomization study

Lactobacillus species ameliorate membranous nephropathy through inhibiting the aryl hydrocarbon receptor pathway via tryptophan‐produced indole metabolites

Deciphering the gut microbiome: The revolution of artificial intelligence in microbiota analysis and intervention

Contact Info

Product

Resources

About