Combination of the Claisen-Schmidt reaction, the Michael addition, and the Hantzsch reaction in the synthesis of 2,6′-bis-aryl-3,4′-bipyridines

Мамедов, В. А.; Мустакимова, Л. В.; Gerasimov, Oleg A.; Губайдуллин, А. Т.

doi:10.1007/s11172-020-2792-9

Cited by 4 publications

(2 citation statements)

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“…New types of heterogeneous catalysts have been reported for synthesis of chalcones with high selectivity thereby avoiding side reactions such as self‐condensation, Cannizaro reaction and Michael addition, making the overall processes green. In one‐pot or cascade or integrated synthesis of compounds that involves consecutive reactions steps, CSC has been extensively used in combination with other reactions such as epoxidation, Michael reaction, dehydration, Hantzsch reaction, hydrolysis, intramolecular addition, and hydrogenation that has wide applications . There are recent reports available on the synthesis of valuable heterocyclic compounds and their derivatives by integrated method or one‐pot protocol involving sequential CSC reactions, which are the most efficient and economic protocols ultimately leading the environmentally friendly process .…”

Section: Introductionmentioning

confidence: 99%

“…In one-pot or cascade or integrated synthesis of compounds that involves consecutive reactions steps, CSC has been extensively used in combination with other reactions such as epoxidation, Michael reaction, dehydration, Hantzsch reaction, hydrolysis, intramolecular addition, and hydrogenation that has wide applications. [4][5][6] There are recent reports available on the synthesis of valuable heterocyclic compounds and their derivatives by integrated method or one-pot protocol involving sequential CSC reactions, which are the most efficient and economic protocols ultimately leading the environmentally friendly process. [7] There are several new heterogeneous catalysts which have been used to intensify rates of CSC reactions including superior conversions and selectivities according to the principles of green chemistry and green engineering; the so-called flow chemistry can also be applied to CSC reactions making them industrially attractive and environmentally benign.…”

Section: Introductionmentioning

confidence: 99%

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Claisen‐Schmidt Condensation using Green Catalytic Processes: A Critical Review

Yadav

Wagh

2020

ChemistrySelect

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Claisen‐Schmidt condensation have historical significance for over140 years and the scope was expanded due to the realization that chalcones so synthesized possess biological activity. The principles of green chemistry with emphasis on use of different solid catalysts with proper distribution of active centers such as acid, base, acid‐base, organo‐ were used along with solvent‐less systems. Among solid bases layered double hydroxides (LDH)/hydrotalcites are the most common. The limitations of solid bases are overcome by solid acids and superacids. A number of metal oxide supports are used. MOFs are increasingly being used. Complex organo‐catalysts are employed for getting excellent regio‐selectivity. In certain metal oxides, both acidic and basic sites co‐exist on the pore surface of catalyst which offer superior results. Synergism of solid catalysis using microwaves and ultrasound to intensify rates and selectivity is in vogue.Controlled pore structure and distribution of active catalytic centers, whether mono‐, bi‐ or tri‐functional catalysts, will give better green and smart processes. The review gives a critical analysis of the area and presents future directions for research.

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Section: Introductionmentioning

confidence: 99%