Combination of thalidomide and Clostridium butyricum relieves chemotherapy-induced nausea and vomiting via gut microbiota and vagus nerve activity modulation

Zhao, Xin; Wu, Heng; Zhu, Ruizhe; Shang, Guanning; Wei, Jing; Shang, Hongyan; Tian, Puyuan; Chen, Tingtao; Wei, Hong

doi:10.3389/fimmu.2023.1220165

Cited by 2 publications

(1 citation statement)

References 59 publications

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“…Recent studies have fully demonstrated that the vagus nerve regulates emotions and behavior by influencing CNS responses ( Fulling et al., 2019 ). The disconnection of vagus nerve can block the central signaling in species belonging to the Lactobacillus and Bifidobacterium genera, resulting in impaired emotional regulation ( Zhao et al., 2023 ). In summary, the vagus nerve plays an indispensable role in the information transmission of gut microbiota and CNS.…”

Section: Signaling Mechanisms Of Microbiota Gut Brain Axis Communicationmentioning

confidence: 99%

Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases

Yuan,

He,

Xie

et al. 2023

Front. Cell. Infect. Microbiol.

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The microbiota gut brain (MGB) axis has been shown to play a significant role in the regulation of inflammatory and infective diseases. Exploring the structure and communication mode of MGB axis is crucial for understanding its role in diseases, and studying the signaling pathways and regulatory methods of MGB axis regulation in diseases is also of profound significance for future clinical research. This article reviews the composition, communication mechanism of MGB axis and its role in inflammatory and infective diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), multiple sclerosis (MS), autism spectrum disorder (ASD), depression, psoriasis, irritable bowel syndrome (IBS), and inflammatory bowel diseases (IBD). In addition, our investigation delved into the regulatory functions of the inflammasome, IFN-I, NF-κB, and PARK7/DJ-1 innate immune signaling pathway in the context of inflammatory and infective diseases. Ultimately, we discussed the efficacy of various interventions, including fecal microbiota transplantation (FMT), antibiotics, probiotics, prebiotics, synbiotics, and postbiotics, in the management of inflammatory and infective diseases. Understanding the role and mechanism of the MGB axis might make positive effects in the treatment of inflammatory and infective diseases.

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Section: Signaling Mechanisms Of Microbiota Gut Brain Axis Communicationmentioning

confidence: 99%

Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases

Yuan,

He,

Xie

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

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Clostridium butyricum regulates intestinal barrier function via trek1 to improve behavioral abnormalities in mice with autism spectrum disorder

Liu,

Xi,

Xue

et al. 2024

Cell Biosci

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Background Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder that has been found to be associated with dysregulation of gastrointestinal functions and gut microbial homeostasis (the so-called “gut-brain axis”). ASD is often accompanied by poor performances in social interaction and repetitive behaviors. Studies on the gut-brain axis provide novel insights and candidate targets for ASD therapeutics and diagnosis. Based on the ASD mice model, this work aims to reveal the mechanisms behind the interaction of intestinal barrier function and probiotics in ASD mouse models. Results We found an altered intestinal barrier in both BTBR T+ Itpr3tf/J (BTBR) and valproic acid (VPA) mice, including increased intestinal permeability, decreased expression of intestinal tight junction proteins (claudin1, claudin3, and occludin), and increased levels of IL-6, TNF-α, and IFN-γ. Based on intestinal microbial alternation, C. butyricum can drive reduced expression of histone deacetylases 1 (HDAC1) and enhanced intestinal barrier function, significantly promoting behavioral abnormalities of ASD in BTBR mice. In parallel, we confirmed that C. butyricum was involved in the regulation of intestinal function by the Trek1 channel, indicating that it is a target of C. butyricum/butyric acid to improve intestinal barrier function in ASD mice. Conclusions Our finding provides solid evidence for the gut microbiota involved in ASD through the brain-gut axis. In addition, the probiotics C. butyricum hold promise to improve gut health and ameliorate behavioral abnormalities associated with ASD.

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Combination of thalidomide and Clostridium butyricum relieves chemotherapy-induced nausea and vomiting via gut microbiota and vagus nerve activity modulation

Cited by 2 publications

References 59 publications

Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases

Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases

Clostridium butyricum regulates intestinal barrier function via trek1 to improve behavioral abnormalities in mice with autism spectrum disorder

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