Combination of surgical resection and HDR-brachytherapy in patients with recurrent or advanced head and neck carcinomas

Schiefke, Franziska; Hildebrandt, Guido; Pohlmann, S.; Heinicke, Frank; Hemprich, Alexander; Frerich, Bernhard

doi:10.1016/j.jcms.2007.08.009

Cited by 37 publications

(35 citation statements)

References 19 publications

(25 reference statements)

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“…In one study, the overall complication rate after tumor resection and postoperative HDR BT was 61%, with wound healing disorders and breakdown being the most frequent acute side effect, as well as late complications, including acute carotid bleeding and osteoradionecrosis (32). Other authors reported an overall complication rate of 35% with acute side effects, including mucositis (60.3% of all patients), pain (19.8% cases), and dysphagia (16% of all patients) (18).…”

Section: Discussionmentioning

confidence: 99%

Endoscopy-guided brachytherapy for sinonasal and nasopharyngeal recurrences

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Endoscopy-guided brachytherapy for sinonasal and nasopharyngeal recurrences

et al. 2015

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“…In the recent report of Schiefke and colleagues (Schiefke et al, 2008), 13 patients with recurrent head and neck carcinomas were treated curatively by surgical resection and high-dose-rate brachy-radiotherapy. The overall survival rate at 2 years was 60%, and mean survival was 22.8 months.…”

Section: Discussionmentioning

confidence: 99%

Post-laryngectomy stomal cancer recurrences, re-treatment decisions and outcomes: Case series

Ampil¹,

Ghali²,

Caldito

et al. 2009

Journal of Cranio-Maxillofacial Surgery

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“…There were no cases of soft-tissue necrosis. Schiefke et al treated 18 patients diagnosed with locally advanced head and neck cancer; treatment was carried out by performing tumor resection and delivering 192Ir-HDR-BRT [34]. A total of 5 patients were treated for primary head and neck cancer; 13 patients were treated for relapse.…”

Section: High-dose-rate Brachytherapy Reirradiationmentioning

confidence: 99%

Re-irradiation for Recurrent Head and Neck Cancer

Rudžianskas¹,

Kupčinskaitė-Noreikienė²

2017

Radiotherapy

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After radical treatment of head and neck cancer about 20-50% of patients are diagnosed with the locoregional recurrence during first two years. The main treatment for recurrent disease is salvage surgery, but in most cases, surgery is not feasible due to the high risk of complications and morbidity, and only 20% of patients are suitable for surgical salvage. Reirradiation is an effective treatment method with acceptable toxicity, but this treatment method is limited to normal tissue tolerance to a total dose. When chemotherapy is administered for recurrence, the response rate is up to 40%, so with the advancement of technical measures, after introduction of intensity-modulated radiotherapy, fractionated stereotactic body radiation therapy, high-dose-rate brachytherapy, proton beam reirradiation, a reirradiation is increasingly more often used for head and neck cancer relapse treatment. In this chapter, we will discuss about reirradiation with curative intent using new different radiation techniques (intensity-modulated radiotherapy (IMRT), stereotactic body radiation therapy (SBRT), high-dose-rate brachytherapy (HDR-BRT) and proton beam reirradiation (PBRT) for previously irradiated head and neck cancer and present recommendations for retreatment of head and neck cancer relapse using reirradiation alone or with systemic chemotherapy/biologic therapy.

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Combination of surgical resection and HDR-brachytherapy in patients with recurrent or advanced head and neck carcinomas

Cited by 37 publications

References 19 publications

Endoscopy-guided brachytherapy for sinonasal and nasopharyngeal recurrences

Endoscopy-guided brachytherapy for sinonasal and nasopharyngeal recurrences

Post-laryngectomy stomal cancer recurrences, re-treatment decisions and outcomes: Case series

Re-irradiation for Recurrent Head and Neck Cancer

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