Combination of submicroemulsion and phospholipid complex for novel delivery of ursodeoxycholic acid

Ma, Ying; Li, Gang; Xu, Jia; Zhang, Jing; Zhang, Zeng-Zhu; Xiao, Hanyang; Li, Xian-Fei

doi:10.3109/10837450.2013.788517

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…To optimize the formulations Box-Behnken design of the experiment (trial version 13.0.2.0, Stat Ease Inc. Minneapolis, USA) was employed, which is a response surface type design of experiment, whereby responses of three components were investigated at three levels 24) . Independent factors such as soya lecithin and Cuscuta reflexa (X1) ; temperature (X2) ; and sonication duration (C) at three levels; low, medium, and high i.e.…”

Section: Experimental Designmentioning

confidence: 99%

Optimization and Characterization of <i>Cuscuta reflexa </i>Extract Loaded Phytosomes by the Box-Behnken Design to Improve the Oral Bioavailability

Alshahrani

2022

J. Oleo Sci.

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IntroductionRecent literature findings have shown bioactive compounds utilized in current therapies have natural origins for the vast majority of the time, according to recent literature studies. This means that they are obtained from natural items or their chemical structure was inspired by natural goods for the most part 1) . Cuscuta reflexa, a member of the Convolvulaceae family, is one such therapeutic plant. According to previous studies, the antioxidant, antibacterial, antispasmodic, hemodynamic, antihypertensive, antidiabetic, hepatoprotective properties of Cuscuta reflexa have been demonstrated 2−4) . Also, from this herb, a wide range of bioactive constituents have been isolated; among them are kaempferol, astragalin, myricetin, quercetin, and sesamin. Other bioactive constituents found in this herb include isorhamnetol, linoleic and/or oleic acids, stearic and/or palmitic acids, luteolin, and sesamin 5−8) .

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Section: Experimental Designmentioning

confidence: 99%

Optimization and Characterization of <i>Cuscuta reflexa </i>Extract Loaded Phytosomes by the Box-Behnken Design to Improve the Oral Bioavailability

Alshahrani

2022

J. Oleo Sci.

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“…Moreover, other UDCA formulations have been developed. For example, by preparing the UDCA submicron emulsion loaded with a UDCA–phospholipid complex, the bioavailability (BA) of UDCA was increased by 374% [ 16 ]. In addition, using a UDCA-phospholipid complex increases the oral BA by 2.4-fold in rats compared with a UDCA suspension [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancing Dissolution and Oral Bioavailability of Ursodeoxycholic Acid with a Spray-Dried pH-Modified Extended Release Formulation

Lee

et al. 2022

Pharmaceutics

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Ursodeoxycholate (UDCA) has low oral bioavailability and pH-dependent solubility and permeability. Thus, we developed a pH-modified extended-release formulation of UDCA using Na2CO3 as the alkalizing agent and hydroxypropyl methylcellulose (HPMC) as the release-modifying agent. The optimized pH-modified controlled-release UDCA formulation, with the UDCA:HPMC:Na2CO3 ratio of 200:600:150 (w/w/w), was prepared using a spray-drying method. Then, the formulation’s solubility, dissolution, and pharmacokinetic properties were characterized. In a pH-modified extended-release formulation of UDCA, the solubility of UDCA was increased to 8 mg/mL with a sustained dissolution for 12 h. Additionally, the spray-dried formulation exhibited amorphous states without molecular interaction among UDCA, Na2CO3, and HPMC. Moreover, the plasma UDCA concentration of the formulation maintained a higher UDCA concentration for up to 48 h than that of UDCA itself or the non-extended-release UDCA formulation. Consequently, the formulation significantly increased the AUC compared to UDCA or the non-extended-release UDCA formulation in rats. In conclusion, we have improved UDCA’s solubility and dissolution profile by preparing a pH-modified extended-release formulation with the UDCA:HPMC:Na2CO3 ratio of 200:600:150 (w/w/w), which effectively increased the oral bioavailability of UDCA by 251% in rats.

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Bioanalysis of ursodeoxycholic acid and its metabolites and improved oral bioavailability using mixed micelles with poloxamer 407 and polysorbate 80

Jeon,

Lee,

Lee

et al. 2024

Biotechnol Bioproc E

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Combination of submicroemulsion and phospholipid complex for novel delivery of ursodeoxycholic acid

Cited by 6 publications

References 14 publications

Optimization and Characterization of <i>Cuscuta reflexa </i>Extract Loaded Phytosomes by the Box-Behnken Design to Improve the Oral Bioavailability

Optimization and Characterization of <i>Cuscuta reflexa </i>Extract Loaded Phytosomes by the Box-Behnken Design to Improve the Oral Bioavailability

Enhancing Dissolution and Oral Bioavailability of Ursodeoxycholic Acid with a Spray-Dried pH-Modified Extended Release Formulation

Bioanalysis of ursodeoxycholic acid and its metabolites and improved oral bioavailability using mixed micelles with poloxamer 407 and polysorbate 80

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