Combination of serum gamma-glutamyltransferase and alkaline phosphatase in predicting the diagnosis of asymptomatic choledocholithiasis secondary to cholecystolithiasis

Mei, Yong; Chen, Li; Peng-fei, Zeng; Peng, Cijun; Wang, Jun; Du, Chao; Xiong, Kun; Leng, Kai; Feng, Chaobo; Jia, Ji-Hu

doi:10.12998/wjcc.v7.i2.137

Cited by 18 publications

(14 citation statements)

References 21 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 20 , 22–24 Serum GGT is mainly derived from the liver, primarily distributed in the liver cytoplasm and intrahepatic bile duct epithelium, and excreted by the biliary tract. 25 When biliary obstruction occurs, GGT secreted by biliary epithelial cells and hepatic cells increases; meanwhile, poor bile excretion causes GGT to be absorbed into the bloodstream, leading to the abnormal increase in serum GGT level. Therefore, GGT can clinically be used in the differential diagnosis of biliary obstruction and is able to reflect the degree of biliary obstruction.…”

Section: Discussionmentioning

confidence: 99%

CA19-9 Level to Serum γ-Glutamyltransferase as a Potential Prognostic Biomarker in Patients with Pancreatic Head Carcinoma

Lyu¹,

Wang²,

Huang³

et al. 2021

CMAR

View full text Add to dashboard Cite

Background The aim of this study was to reduce the influence of biliary obstruction on carbohydrate antigen 19-9 level (CA19-9) by introducing the CA19-9 level to serum γ-glutamyltransferase (GGT) ratio as an indicator, and ultimately to reveal the correlation between CA19-9/GGT and the prognosis of patients with pancreatic head carcinoma (PHC). Methods A total of 339 enrolled patients who underwent pancreatoduodenectomy for PHC in Beijing ChaoYang Hospital from January 2010 to December 2019 were analyzed retrospectively. The optimal cut-off value, according to which patients were divided into a low-ratio group (Group 1, n=179) and a high-ratio group (Group 2, n=160), was determined by the ROC curve obtained from preoperative CA19-9/GGT and 1-year survival. Through univariate and multivariate analyses, risk factors for postoperative tumor recurrence and long-term survival were screened out among PHC patients. Results The best cut-off value of CA19-9/GGT was 2.07 (area under the curve=0.567, 95% CI 0.498–0.636). Compared with Group 2, Group 1 had lower CA19-9, and higher GGT, total bilirubin (TB) and lymph-node metastasis rate ( P <0.05). The 1-, 2- and 3-year disease-free survival rates of patients in Groups 1 and 2 were 68.2%, 42.5% and 28.2%, and 42.2%, 19.3% and 18.3%, respectively ( P =0.000), and the 1-, 2- and 3-year overall survival rates were 79.1%, 50.7% and 29.1%, and 56.7%, 22.2% and 17.2%, respectively ( P =0.000). Multivariate analysis showed that CA19-9/GGT, portal system invasion and lymph-node metastasis were independent risk factors for postoperative tumor recurrence and long-term survival among patients with PHC. Conclusion Compared with CA19-9 level alone, CA19-9/GGT plays a more precise role in the evaluation of postoperative tumor recurrence and the long-term prognosis of PHC patients. The lower the ratio, the better the long-term prognosis. The CA19-9/GGT ratio may prove to be a useful biomarker for identifying PHC patients at high risk of early recurrence and unfavorable prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

CA19-9 Level to Serum γ-Glutamyltransferase as a Potential Prognostic Biomarker in Patients with Pancreatic Head Carcinoma

Lyu¹,

Wang²,

Huang³

et al. 2021

CMAR

View full text Add to dashboard Cite

show abstract

“…GGT is produced by the hepatocyte mitochondria and confined to the cytoplasm and intrahepatic bile duct epithelium [41]. Previous studies have demonstrated that GGT is significantly and negatively associated with an increase in physical activity [42,43].…”

Section: Discussionmentioning

confidence: 99%

Effect of a combination of aerobic exercise and dietary modiﬁcation on liver function in overweight and obese men

2021

JOMH

View full text Add to dashboard Cite

Background: Obesity is not only associated with cardiovascular diseases but also a primary cause of liver dysfunction and other related diseases. This study's aim was to determine the impact of a combination of dietary modiﬁcation and aerobic exercise on liver function in overweight and obese adult males. Methods: 45 overweight or obese men were randomly divided between the control group (n = 22) and intervention group (n = 23). Subjects in the intervention group were provided with dietary modiﬁcation and aerobic exercise programmes. Dietary modiﬁcation is a diet which restricts calorie intake and balances nutrients. Before and after 12 weeks of intervention, participants' anthropometric characteristics and biochemical parameters relating to liver function including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) were measured. Results: 12 weeks of aerobic exercise and dietary modiﬁcation resulted in average weight loss of 10.6%, and body mass index, waist circumference and fat percentage decreased by 10.2%, 9.4% and 14.5% (P < 0.05). AST, ALT, GGT and ALP in the intervention group reduced by 20.6%, 18.1%, 37.7% and 6.1% (P < 0.05). Compared to the control group, AST, ALT, GGT and ALP in the intervention group were markedly lower (P < 0.05). Furthermore, there was a markedly positive relationship between the reduction rates of body weight and GGT (P < 0.05). Conclusion: 12 weeks of aerobic exercise and dietary modiﬁcation caused signiﬁcant weight, waist circumference and body fat percentage reduction in overweight and obese men and their liver function was improved. The ﬁndings can provide a scientiﬁc reference for the improvement of liver function and prevention of liver diseases among overweight and obese people.

show abstract

“…GGT participates in oxidative stress and plays a proinflammatory role, leading to the occurrence of various chronic metabolic diseases, and is closely related to the occurrence and development of tumors[ 10 , 11 ]. Serum GGT is mainly secreted from the hepatobiliary system and is excreted by bile[ 12 ]. After biliary obstruction leads to bile drainage obstruction, GGT produced by bile duct epithelial cells and hepatocytes increases, and, due to bile excretion obstruction, GGT enters the blood in reverse flow, and may result in an atypical increase in GGT.…”

Section: Introductionmentioning

confidence: 99%

Carbohydrate antigen 19-9 as a novel prognostic biomarker in distal cholangiocarcinoma

Jiang¹,

Lyu²,

Zhou³

et al. 2021

WJGS

View full text Add to dashboard Cite

BACKGROUND Distal cholangiocarcinoma (DCC) presents as one of the relatively rare malignant tumors in the digestive system and has a poor long-term prognosis. Curative resection is currently the most appropriate therapy for patients with DCC because of the lack of effective adjuvant therapies. Therefore, it is important to accurately predict the prognosis for formulating a reasonable treatment plan and avoiding unnecessary surgical trauma. AIM To minimize the interference of obstructive jaundice on carbohydrate antigen 19-9 (CA19-9) level by adapting CA19-9 to γ-glutamyltransferase (GGT) as an indicator, to determine the strong associations between CA19-9/GGT and postoperative neoplasm recurrence and long-term outcome of DCC. METHODS We enrolled 186 patients who were diagnosed with DCC between January 2010 and December 2019 and performed radical excision with strict criteria as follows in our hospital. Receiver operating characteristic curves were drawn according to preoperative CA19-9/GGT and 1-year survival. Based on this, patients were divided into two groups (group 1, low-ratio, n = 81; group 2, high-ratio, n = 105). Afterwards, by the way of univariate and multivariate analysis, the risk factors influencing postoperative tumor recrudesce and long-term prognosis of patients with DCC were screened out. RESULTS Optimum cut-off value of CA19-9/GGT was 0.12. Patients in group 2 represented higher CA19-9 and lymphatic metastasis rate accompanied by lower GGT, when compared with group 1 ( P < 0.05). The 1-, 3- and 5-year overall survival rates of patients in groups 1 and 2 were 88.3%, 59.2% and 48.1%, and 61.0%, 13.6% and 13.6%, respectively ( P = 0.000). Multivariate analysis indicated that CA19-9/GGT, lymphatic metastasis and tumor differentiation were independent risk factors for tumor recurrence and long-term prognosis of DCC. CONCLUSION Elevation of CA19-9/GGT performed better as a biomarker of aggressive carcinoma and predictor of poor clinical outcomes by reducing the effect of obstruction of biliary tract on CA19-9 concentration in patients with DCC.

show abstract

Combination of serum gamma-glutamyltransferase and alkaline phosphatase in predicting the diagnosis of asymptomatic choledocholithiasis secondary to cholecystolithiasis

Cited by 18 publications

References 21 publications

CA19-9 Level to Serum γ-Glutamyltransferase as a Potential Prognostic Biomarker in Patients with Pancreatic Head Carcinoma

CA19-9 Level to Serum γ-Glutamyltransferase as a Potential Prognostic Biomarker in Patients with Pancreatic Head Carcinoma

Effect of a combination of aerobic exercise and dietary modiﬁcation on liver function in overweight and obese men

Carbohydrate antigen 19-9 as a novel prognostic biomarker in distal cholangiocarcinoma

Contact Info

Product

Resources

About