Combination of Serum Adiponectin Level and Metabolic Syndrome is Closely Associated with Coronary Artery Disease in Japanese Subjects with Good Glycemic Control

Yamashita, Toru; Matsuda, Morihiro; Nishimoto, Orie; Nakamoto, Kei; Nishiyama, Hirohiko; Matsumoto, Kengo; Tamura, Ritsu; Kawamoto, Toshiharu

doi:10.2169/internalmedicine.49.2897

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…It is known that hyperinsulinemia or hypoadiponectinemia is the risk factor of coronary artery disease independent of fasting blood glucose. 30 , 31 All of these data indicate that the indices determined from PFAA profiles may have the potential ability to assess the state of diabetic patients from the different viewpoint of the existing glycemic variables. To utilize these indices as monitoring markers, it is needed to study whether the normalization of the PFAA profile and the index values correlate with the improvement of insulin resistance or the increase in circulating adiponectin level.…”

Section: Discussionmentioning

confidence: 97%

Plasma amino acid profiles are associated with insulin, C-peptide and adiponectin levels in type 2 diabetic patients

et al. 2014

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Objectives:Plasma-free amino acid (PFAA) profiles have been associated with a future risk of developing diabetes or cardiovascular disease in nondiabetic subjects. These PFAA alterations might predominantly result from the metabolic shift caused by insulin resistance and visceral fat deposition. The variety of PFAA profiles within diabetic subjects is not well researched. In this study, we focused on type 2 diabetic subjects and examined the association between PFAA profiles and insulin- and glucose-related variables.Methods:Fifty-one Japanese subjects diagnosed with type 2 diabetes were recruited from an outpatient clinic. The plasma concentrations of 21 amino acids; glucose-related markers including glucose, hemoglobin A1c (HbA1c), glycoalbumin and 1,5-anhydroglucitol; insulin-related markers including insulin, C-peptide, and the homeostasis model assessment of insulin resistance; and adipocytokines including adiponectin and leptin were determined. The association of PFAA and other metabolic profiles were analyzed, and stratified analyses of the PFAAs and clinical characteristics were performed according to the fasting plasma insulin and HbA1c levels. In addition, the PFAA indices that correlate to visceral fat obesity were evaluated.Results:Although strong correlations between PFAAs and glucose-related markers were not observed, several amino acids (branched-chain amino acids, tryptophan, alanine, tyrosine, glutamate and proline) and PFAA indices that evaluate visceral obesity were highly correlated with insulin-related markers and adiponectin (P<0.001). In the group of diabetic patients with hyperinsulinemia, the amino acid levels were significantly increased, which generally demonstrated good concordance with insulin-related markers and adiponectin levels.Conclusions:The PFAA profiles in diabetic patients were strongly associated with hyperinsulinemia and hypoadiponectinemia, which might become risk evaluation factors for the development of cardiovascular diseases.

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Section: Discussionmentioning

confidence: 97%

Plasma amino acid profiles are associated with insulin, C-peptide and adiponectin levels in type 2 diabetic patients

et al. 2014

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“…Compared with wild-type mice, adiponectin-null mice develop more severe atherosclerosis when the vascular wall is vitro and in vivo experiments 18,19) . Furthermore, low adiponectin levels are associated with the presence of CAD [36][37][38] . Recent clinical studies have shown that low adiponectin levels are associated with noncalcified and mixed plaques detected on CTCA [23][24][25] .…”

Section: 315mentioning

confidence: 99%

Predictive Value of Adiponectin in Patients with Multivessel Coronary Atherosclerosis Detected on Computed Tomography Angiography

Matsuda

Tamura

Kishida

et al. 2013

JAT

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“…Circulating amount of oxidation-related moiety on low density lipoprotein has been shown to be effective to predict or diagnose MS and cardiovascular diseases (8). Combination of serum adiponectin level and MS is closely associated with CAD (9). Nevertheless, rare studies revealed the effect of LOX-1 in predicting MS.…”

Section: Introductionmentioning

confidence: 99%

Serum Lectin-Like Oxidized-Low Density Lipoprotein Receptor-1 and Adiponectin Levels Are Associated With Coronary Artery Disease Accompanied With Metabolic Syndrome

Sheikh¹,

Zhao²,

Guo³

et al. 2014

Iran Red Crescent Med J

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Background:Coronary artery disease (CAD) is a major public health problem for developed and developing countries and is the single leading cause of death worldwide.Objectives:There is very few evidence regarding changes of both serum Lectin-like oxidized-low density lipoprotein receptor-1 (LOX-1) and adiponectin in patients with CAD accompanied with metabolic syndrome (MS). Here we aimed to evaluate serum levels of LOX-1 and adiponectin in patients with CAD accompanied with MS.Patients and Methods:Thirty patients with coronary artery disease without metabolic syndrome, 30 patients with coronary artery disease and metabolic syndrome, 30 ones with metabolic syndrome and 30 healthy subjects were enrolled. For all subjects, a questionnaire was filled to collect data, and peripheral blood samples were collected aseptically from the antecubital vein to measure serum Lectin-like oxidized-low density lipoprotein receptor-1 and adiponectin levels by enzyme-linked immunosorbent assay.Results:Serum LOX-1 level was highest in CAD + MS group; the difference between control and disease groups was statistically significant (P < 0.001). Adiponectin level had the lowest value in CAD + MS group; the difference between control and disease groups was statistically significant (P < 0.05). No significant differences were observed in serum Lectin-like oxidized-low density lipoprotein receptor-1and adiponectin in patients with different ages and gender. Serum LOX-1 level was changed negatively and linearly (R2 = 0.721) correlated with adiponectin level in different groups.Conclusions:Patient with CAD and MS had higher risk than those with only CAD because of lipid and glucose metabolism abnormalities. Combination measurements of serum LOX-1 and adiponectin levels may be helpful to evaluate the severity of CAD together with MS.

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Combination of Serum Adiponectin Level and Metabolic Syndrome is Closely Associated with Coronary Artery Disease in Japanese Subjects with Good Glycemic Control

Abstract: Objective Metabolic syndrome (MetS)

Cited by 10 publications

References 25 publications

Plasma amino acid profiles are associated with insulin, C-peptide and adiponectin levels in type 2 diabetic patients

Plasma amino acid profiles are associated with insulin, C-peptide and adiponectin levels in type 2 diabetic patients

Predictive Value of Adiponectin in Patients with Multivessel Coronary Atherosclerosis Detected on Computed Tomography Angiography

Serum Lectin-Like Oxidized-Low Density Lipoprotein Receptor-1 and Adiponectin Levels Are Associated With Coronary Artery Disease Accompanied With Metabolic Syndrome

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