Abstract:Breast cancer (BC) is the most prevalent diagnosed cancer among women. Herceptin blocks the effects of Her‐2 and tumour cell growth. Despite many achievements using Herceptin in Her‐2+ invasive BC treatment, there are treatment failures and resistances. The signal transducer and activator of transcription 3 (STAT3) is persistently activated in BC and is associated with immune suppression and tumour cell proliferation. We evaluated whether STAT3 inhibition could increase Herceptin impact on in vitro reduction o… Show more
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