Abstract:Diabetic overweight patients are more likely to show the progression of kidney damage than the general population. The majority of people in the early stages of kidney damage do not recognize the importance of risk modification, mainly due to the asymptomatic nature of the disease. This study aimed to examine specific risk combinations of lifestyle and BMI regarding the deterioration of kidney function and to explore whether there are gender-based differences among the prediabetic population. Prediabetic parti… Show more
“… 9 , 10 , 11 , 12 , 13 , 14 A prospective cohort study in Japan concluded that smoking, snacking, irregular exercise, and sleep deprivation accelerate the progression of kidney injury in the male population with diabetes. 15 Previous studies have also shown that vegan and low‐salt diets can prevent DKD and its progression. 16 , 17 A Mendelian randomization study found that short sleep duration had a detrimental effect on kidney function.…”
Background
Diabetic kidney disease (DKD) is a common diabetic complication and increases the complexity of diabetes management. No prospective study has focused on the association between DKD and Life's Essential 8 (LE8). Our study aims to examine the association between LE8 and DKD risk.
Methods and Results
A total of 7605 participants, aged 54.32±9.77 years, and 4688 participants, aged 56.11±10.38 years, were included in the longitudinal and trajectory analyses, respectively, from 2006 to 2020. The DKD was confirmed using data collected during each follow‐up. LE8 was based on 4 health behaviors and 4 health factors. The range of each metric was 0 to 100, and the overall LE8 score was calculated as the unweighted average of all 8 component metric scores. The trajectories of LE8 during 2006 to 2010 were classified using latent mixture models. Cox models and restricted cubic splines were applied. After a median follow‐up of 12.41 and 6.71 years in longitudinal and trajectory analyses, respectively, the DKD incidence decreased, with the LE8 level increasing (
P
‐trend<0.05), and the linearity assumption for this relationship (
P
‐nonlinear=0.685) had been satisfied. Adjusted hazard ratios (HRs) for the highest tertile were 0.77 (95% CI, 0.69–0.87) and 0.70 (95% CI, 0.62–0.78) in baseline and time‐updated LE8 scores, respectively, compared with the lowest tertile. Adjusted HR was 0.53 (95% CI, 0.41–0.69) for the stable‐high pattern compared with the stable‐low pattern.
Conclusions
Although LE8 is an indicator of cardiovascular health, the beneficial impact of a high LE8 score is also evident in the protection of renal health among patients with diabetes.
“… 9 , 10 , 11 , 12 , 13 , 14 A prospective cohort study in Japan concluded that smoking, snacking, irregular exercise, and sleep deprivation accelerate the progression of kidney injury in the male population with diabetes. 15 Previous studies have also shown that vegan and low‐salt diets can prevent DKD and its progression. 16 , 17 A Mendelian randomization study found that short sleep duration had a detrimental effect on kidney function.…”
Background
Diabetic kidney disease (DKD) is a common diabetic complication and increases the complexity of diabetes management. No prospective study has focused on the association between DKD and Life's Essential 8 (LE8). Our study aims to examine the association between LE8 and DKD risk.
Methods and Results
A total of 7605 participants, aged 54.32±9.77 years, and 4688 participants, aged 56.11±10.38 years, were included in the longitudinal and trajectory analyses, respectively, from 2006 to 2020. The DKD was confirmed using data collected during each follow‐up. LE8 was based on 4 health behaviors and 4 health factors. The range of each metric was 0 to 100, and the overall LE8 score was calculated as the unweighted average of all 8 component metric scores. The trajectories of LE8 during 2006 to 2010 were classified using latent mixture models. Cox models and restricted cubic splines were applied. After a median follow‐up of 12.41 and 6.71 years in longitudinal and trajectory analyses, respectively, the DKD incidence decreased, with the LE8 level increasing (
P
‐trend<0.05), and the linearity assumption for this relationship (
P
‐nonlinear=0.685) had been satisfied. Adjusted hazard ratios (HRs) for the highest tertile were 0.77 (95% CI, 0.69–0.87) and 0.70 (95% CI, 0.62–0.78) in baseline and time‐updated LE8 scores, respectively, compared with the lowest tertile. Adjusted HR was 0.53 (95% CI, 0.41–0.69) for the stable‐high pattern compared with the stable‐low pattern.
Conclusions
Although LE8 is an indicator of cardiovascular health, the beneficial impact of a high LE8 score is also evident in the protection of renal health among patients with diabetes.
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