Combination of Rigorous and Statistical Modeling for Process Development of Plant‐Based Extractions Based on Mass Balances and Biological Aspects

Abstract

A rigorous model supported by botanical investigations has been developed to predict percolation results. Botanical investigations provide needed modeling parameters like pore size, porosity, or target compound distributions over the particle. After determining the desorption isotherm with maceration experiments at different solvent-feed ratios, the model is validated with short residence time percolation experiments. With the aid of this validated model, percolation experiments with long residence times can be predicted and different process scenarios calculated. A combination of design of experiments and rigorous modeling together with standard equipment and experimental model parameter determination provides a fast and robust experimental design on the one hand and the precondition for a process parameter data-based learning curve on the basis of rigorous modeling in the mid-or long-term on the other hand.

Systematic and Model-Assisted Evaluation of Solvent Based- or Pressurized Hot Water Extraction for the Extraction of Artemisinin from Artemisia annua L.

“…The fractions serve for the determination of the extraction curve. The experimental setups have already been described by the authors [1,29].…”

“…Thus, the most important extraction technique to achieve this aim is percolation. For process design and optimization, modeling and simulation was proven to be a beneficial approach [1,3,4,7,29,31]. Commonly, the extraction in percolation mode is described with various sub models which will be described in the following in detail.…”

“…The demand for natural derived products is still growing [1,2]. Among other purposes, they are used as food supplements, natural plant protection agents and pharmaceuticals.…”

Determining the solute–solid interactions in phytoextraction

“…Although they show results in their publication, it remains unclear, how these were calculated from the experiments. Additionally, their (Kassing et al, 2012) experimental procedure is valid only, when the solute is completely extracted out of the solid material. In their experiments proposed, it cannot be distinguished, whether the solute is adsorbed on the surface of the plant material, due to the solute-solid interactions or whether it stays inside the plant material and, hence, is not extracted.…”

“…Kassing et al (2012) proposed to determine the solute-solid interactions from multistage maceration experiments and to use classical isotherms known from adsorption to fit the results. Although they show results in their publication, it remains unclear, how these were calculated from the experiments.…”