Combination of retinyl palmitate and UV-filters: Phototoxic risk assessment based on photostability and in vitro and in vivo phototoxicity assays

Benevenuto, Carolina Gomes; Guerra, Lucas Offenbecker; Gaspar, Lorena Rigo

doi:10.1016/j.ejps.2014.12.007

Cited by 32 publications

(18 citation statements)

References 32 publications

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“…The formation of reactive intermediates with adverse side effects as a result of significant photounstability (Yang et al, 2008;Hojerov a et al, 2011;Gaspar et al, 2013;Alfonso et al, 2014;Benevenuto et al, 2015) is the most undesirable side effect associated with the skin absorption of BMDBM.…”

Section: Introductionmentioning

confidence: 98%

Skin absorption and human exposure estimation of three widely discussed UV filters in sunscreens – In vitro study mimicking real-life consumer habits

Klímová

Hojerová

Beránková

2015

Food and Chemical Toxicology

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Section: Introductionmentioning

confidence: 98%

Skin absorption and human exposure estimation of three widely discussed UV filters in sunscreens – In vitro study mimicking real-life consumer habits

Klímová

Hojerová

Beránková

2015

Food and Chemical Toxicology

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“…Chemoprevention through natural products has alarmed a huge population because of its natural occurrence, no or minimal adverse effect and low price and thus scientists are working on making an effective delivery system and dosage form to be administered by patients [ 19 ]. NAR is a flavanone (5,7,4-trihydroxyflavanone or 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) found especially in citrus fruits, and grapefruit [ 20 ]. NAR has attracted a number of scientists because of its anticancer, antimutagenic, anti-inflammatory, antiatherogenic, antifibrogenic and free radical scavenging properties [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Decorated Naringenin Nanoparticles: Appraisal of Chemopreventive and Curative Potential for Lung Cancer

et al. 2018

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Lung carcinoma is the most common cancer in men and second in women (preceded by breast cancer) worldwide. Around 1 in 10 of all cancers diagnosed in men, lung cancer contributed to a total fraction of 20% cancer deaths. Naringenin (NAR) is well known for its chemopreventive properties since ancient times but lacks an appropriate delivery carrier. The objective of present study was to expand the functionality of naringenin loaded poly caprolactone (PCL) nanoparticles in terms of release, chemoprevention and therapeutics. Polymeric nanoparticles such as PCL lack target specificity; hence, surface modification was attempted using layer by layer technique (LBL) to achieve improved and desired delivery as well as target specificity. The designing of Hyaluronic acid (HA) decorated PCL nanoparticles were prepared by utilizing self-assembling LBL technique, where a polycationic layer of a polymer was used as a linker for modification between two polyanionic layers. Additionally, an attempt has been made to strengthen the therapeutic efficacy of PCL nanocarriers by active targeting and overcoming the extracellular matrix associated barriers of tumors using HA targeting cluster determinant 44 receptor (CD44). Cell cytotoxicity study on A549 cells and J774 macrophage cells depicted enhanced anticancer effect of NAR-HA@CH-PCL-NP with safe profile on macrophages. Uptake study on A549 cells advocated enhanced drug uptake by cancer cells. Cell cycle arrest analysis (A549 cell lines) demonstrated the superior cytotoxic effect and active targeting of NAR-HA@CH-PCL-NP. Further chemopreventive treatment with NAR-HA@CH-PCL-NP was found effective in tumor growth inhibitory effect against urethane-induced lung cancer in rat. In conclusion, developed formulation possesses a promising potential as a therapeutic and chemopreventive agent against urethane-induced lung carcinoma in albino wistar rats.

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“…1, and loses efficiency as photoprotective agent (Miranda et al 2014;Pattanaargson et al 2004). Despite the known photo-isomerization of OMC, the topical application of this UV filter (alone, or in a UV-filter mixture) is well tolerated, with little or negligible skin irritation, adverse reactions (erythema, edema, papules, or vesicles), and phototoxic or photoallergenic effects (Benevenuto et al 2015;Darvay et al 2001;Duale et al 2010;Tampucci et al 2017). However, some authors reported an increased toxicity as a result of breakdown of OMC following UV irradiation (Butt and Christensen 2000;Duale et al 2010;Hanson et al 2015).…”

Section: Uv-b Filter Octylmethoxycinnamate Photoinstabilitymentioning

confidence: 99%

Antioxidants as stabilizers of UV filters: an example for the UV-B filter octylmethoxycinnamate

Lorigo

2019

biomed dermatol

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Background: Sunlight is one of the main harmful exogenous factors that induce the reactive oxygen species formation. The human skin is the first line of photoprotection against harmful exogenous factors, such as UV radiations. The topical application of sunscreens, containing UV-B filters, is widely used to protect against UV-induced damage. Octylmethoxycinnamate is the world's most widely used UV-B filter in sunscreens. However, recent studies have demonstrated that this substance is an endocrine disruptor compound and with potential to damage DNA. Thus, the safety of this organic filter is a current concern for human health, and it was urgent to develop new photoprotective strategies. In this sense, due to the potential to neutralize the UV-induced free radicals, the use of antioxidants as UV filter stabilizers presented as a novel promising strategy. Research: The purpose of this review was to assess the use of antioxidants as stabilizers for UV-B filter octylmethoxycinnamate. For this, we discuss the chemical and physical characteristics of UV-B filter octylmethoxycinnamate, emphasizing the stability, photostability, and reactivity of this UV filter. The use of antioxidants in sunscreens will also be addressed, from a perspective of the main characteristics that allowed their use in sunscreen formulations. Then, the concomitant use of both was described from a historical and physical chemical perspective, always emphasizing the advantages and disadvantages of this association. Conclusions: The combination of antioxidants with UV-B filter octylmethoxycinnamate in appropriated formulations represents a viable strategy to protect the human skin against UV-induced damage.

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Combination of retinyl palmitate and UV-filters: Phototoxic risk assessment based on photostability and in vitro and in vivo phototoxicity assays

Cited by 32 publications

References 32 publications

Skin absorption and human exposure estimation of three widely discussed UV filters in sunscreens – In vitro study mimicking real-life consumer habits

Skin absorption and human exposure estimation of three widely discussed UV filters in sunscreens – In vitro study mimicking real-life consumer habits

Hyaluronic Acid Decorated Naringenin Nanoparticles: Appraisal of Chemopreventive and Curative Potential for Lung Cancer

Antioxidants as stabilizers of UV filters: an example for the UV-B filter octylmethoxycinnamate

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