Combination of real-time elastography and urine prostate cancer gene 3 (PCA3) detects more than 97% of significant prostate cancers

Nygård, Yngve; Haukaas, Svein A.; Waage, Jo Erling Riise; Halvorsen, Ole J.; Gravdal, Karsten; Frugård, Jannicke; Akslen, Lars A.; Beisland, Christian

doi:10.3109/00365599.2012.727859

Cited by 10 publications

(12 citation statements)

References 18 publications

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“…Maybe this multiparametric way—adding tissue informations about contrast media dynamics to grey-scale ultrasound and RTE—could have detected some of our false negative findings. Brock et al have shown the usefulness of this approach, whereas Nygård et al demonstrated the benefit of adding new biomarkers, like PCA-3, to RTE findings for the detection of significant disease [24, 25]. …”

Section: Discussionmentioning

confidence: 99%

Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section Analysis

Junker

Schäfer

Schullian

et al. 2012

The Scientific World Journal

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Objectives. To evaluate prostate cancer (PCa) detection rates of real-time elastography (RTE) in dependence of tumor size, tumor volume, localization and histological type. Materials and Methods. Thirdy-nine patients with biopsy proven PCa underwent RTE before radical prostatectomy (RPE) to assess prostate tissue elasticity, and hard lesions were considered suspicious for PCa. After RPE, the prostates were prepared as whole-mount step sections and were compared with imaging findings for analyzing PCa detection rates. Results. RTE detected 6/62 cancer lesions with a maximum diameter of 0–5 mm (9.7%), 10/37 with a maximum diameter of 6–10 mm (27%), 24/34 with a maximum diameter of 11–20 20 mm (70.6%), 14/14 with a maximum diameter of >20 mm (100%) and 40/48 with a volume ≥0.2 cm3 (83.3%). Regarding cancer lesions with a volume ≥ 0.2 cm³ there was a significant difference in PCa detection rates between Gleason scores with predominant Gleason pattern 3 compared to those with predominant Gleason pattern 4 or 5 (75% versus 100%; P = 0.028). Conclusions. RTE is able to detect PCa of significant tumor volume and of predominant Gleason pattern 4 or 5 with high confidence, but is of limited value in the detection of small cancer lesions.

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Section: Discussionmentioning

confidence: 99%

Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section Analysis

Junker

Schäfer

Schullian

et al. 2012

The Scientific World Journal

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“…Nygård et al demonstrated the benefit of adding new biomarkers, like PCA-3, to RTE findings for the detection of significant disease [37]. …”

Section: Rte Before Radical Prostatectomy (Rpe)mentioning

confidence: 99%

Real-Time Elastography of the Prostate

Junker

Zordo

Quentin

et al. 2014

BioMed Research International

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Palpation of organs is one of the oldest clinical examination techniques, for instance, if you think of the palpation of the breast or the digital rectal examination of the prostate, where hard palpable regions are suspicious for cancer. This is the basic principle of real-time elastography, an ultrasound technique, which is able to visualise tissue elasticity. Since prostate cancer features an increased stiffness due to the higher cell and vessel density than the normal surrounding tissue, real-time elastography has been used for several years for prostate cancer detection. This review introduces the different techniques of ultrasound elastography and furthermore summarises its limitations and potentials.

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“…The prostate was divided into six peripheral zone (PZ) regions excluding the transition zone (TZ) from the investigation . Each region was examined for cancer suspicious lesions with both methods starting with B‐mode.…”

Section: Methodsmentioning

confidence: 99%

“…The prostate was divided into six peripheral zone (PZ) regions excluding the transition zone (TZ) from the investigation [8].…”

Section: Us Rte Targeted Biopsies Standard Biopsies and Report Formsmentioning

confidence: 99%

A positive real‐time elastography is an independent marker for detection of high‐risk prostate cancers in the primary biopsy setting

et al. 2013

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Objective• To evaluate the performance of real-time elastography (RTE) in an initial biopsy setting. Patients and Methods• In the period from February 2011 to June 2012, 127 consecutive patients were included in the study.• We used a Hitachi Preirus with Hi-RTE module, a prostate end-fire transrectal probe was used for RTE and for targeted biopsies, and a simultaneous biplane probe was used for the standard systematic biopsies.• The peripheral zone of the prostate was divided into six regions, and each biopsy obtained was referred to a specific region.• All patients were first examined with RTE and, if cancer was suspected, targeted biopsies were taken. A standard systematic 10-core biopsy was then taken in all patients. Results• In all, 64 (50%) patients were diagnosed with prostate cancer in the initial biopsy setting. Three patients were diagnosed solely on RTE-targeted biopsies, 31 were found only in systematic biopsies, and 30 were correctly diagnosed with both methods.• In the RTE-positive group there was a significantly higher frequency of positive cores, a lower prostate volume, a higher Gleason score, and a higher fraction of cancer tissue in each core.• In a multiple regression model RTE was an independent marker for high-risk cancer.• The sensitivity of 42% for all prostate cancers increased to 60% for high-grade prostate cancers.• Similarly, the negative predictive value increased from 79% to 97%. An additional eight patients were diagnosed with prostate cancer during the study period. Conclusions• A positive RTE is an independent marker for detection of high-risk prostate cancer, and a negative RTE argues against such.• RTE with targeted biopsies cannot replace systematic biopsies, but provides valuable additional information about the tumours.

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Combination of real-time elastography and urine prostate cancer gene 3 (PCA3) detects more than 97% of significant prostate cancers

Abstract: The combination of PCA3 score and RTE detected 97% of significant prostate cancers. The combinative use of RTE and PCA3 will be further investigated in an unselected series of men with suspected prostate cancer.

Cited by 10 publications

References 18 publications

Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section Analysis

Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section Analysis

Real-Time Elastography of the Prostate

A positive real‐time elastography is an independent marker for detection of high‐risk prostate cancers in the primary biopsy setting

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