Combination of radiation therapy-immunotherapy for head and neck cancers: Promises kept?

Huguet, F.; Durand, Bernard; Atallah, Sarah; Prebet, Coralie; Richard, Sandrine; Baujat, B.

doi:10.1016/j.canrad.2021.08.018

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…suggesting concomitant treatment with ICB as a strategy to improve HNSCC radiation response. Nonetheless, multiple clinical trials have failed to offer strong evidence for synergy [147][148][149]. Besides its direct cytotoxic effects, radiation can modulate inflammation in the tumor microenvironment associated with immunogenic cell death, activated lymphocytic infiltrates and increased antigen presentation.…”

Section: Radiation Sensitizationmentioning

confidence: 99%

Statins in Cancer Prevention and Therapy

Ricco

Kron

2023

Cancers

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Statins, a class of HMG-CoA reductase inhibitors best known for their cholesterol-reducing and cardiovascular protective activity, have also demonstrated promise in cancer prevention and treatment. This review focuses on their potential applications in head and neck cancer (HNC), a common malignancy for which established treatment often fails despite incurring debilitating adverse effects. Preclinical and clinical studies have suggested that statins may enhance HNC sensitivity to radiation and other conventional therapies while protecting normal tissue, but the underlying mechanisms remain poorly defined, likely involving both cholesterol-dependent and -independent effects on diverse cancer-related pathways. This review brings together recent discoveries concerning the anticancer activity of statins relevant to HNC, highlighting their anti-inflammatory activity and impacts on DNA-damage response. We also explore molecular targets and mechanisms and discuss the potential to integrate statins into conventional HNC treatment regimens to improve patient outcomes.

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Section: Radiation Sensitizationmentioning

confidence: 99%

Statins in Cancer Prevention and Therapy

Ricco

Kron

2023

Cancers

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“…Combining these treatments with immunotherapy, which activates the body's immune system to recognize and attack cancer cells, has a synergistic effect ( 104 ). Immunotherapy helps in enhancing the immune response, making it more effective in recognizing and eliminating cancer cells ( 166 ). However, the prognosis of combining immunochemotherapy and immunoradiotherapy for head and neck cancer can vary depending on several factors, such as the stage and type of cancer, the overall health of the patient and the individual response to treatment ( 167 ).…”

Section: Prognosis Of Combining Immunochemotherapy and Immunoradiothe...mentioning

confidence: 99%

Expanding the role of combined immunochemotherapy and immunoradiotherapy in the management of head and neck cancer (Review)

Wei,

Lan,

Qiu

et al. 2023

Oncol Lett

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Immunotherapy has become one of the most promising approaches in tumor therapy, and there are numerous associated clinical trials in China. As an immunosuppressive tumor, head and neck squamous cell carcinoma (HNSCC) carries a high mutation burden, making immune checkpoint inhibitors promising candidates in this field due to their unique mechanism of action. The present review outlines a comprehensive multidisciplinary cancer treatment approach and elaborates on how combining immunochemotherapy and immunoradiotherapy guidelines could enhance clinical efficacy in patients with HNSCC. Furthermore, the present review explores the immunology of HNSCC, current immunotherapeutic strategies to enhance antitumor activity, ongoing clinical trials and the future direction of the current immune landscape in HNSCC. Advanced-stage HNSCC presents with a poor prognosis, low survival rates and minimal improvement in patient survival trends over time. Understanding the potential of immunotherapy and ways to combine it with surgery, chemotherapy and radiotherapy confers good prospects for the management of human papillomavirus (HPV)-positive HNSCC, as well as other HPV-positive malignancies. Understanding the immune system and its effect on HNSCC progression and metastasis will help to uncover novel biomarkers for the selection of patients and to enhance the efficacy of treatments. Further research on why current immune checkpoint inhibitors and targeted drugs are only effective for some patients in the clinic is needed; therefore, further research is required to improve the overall survival of affected patients.

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Combination of radiation therapy-immunotherapy for head and neck cancers: Promises kept?

Cited by 2 publications

References 34 publications

Statins in Cancer Prevention and Therapy

Statins in Cancer Prevention and Therapy

Expanding the role of combined immunochemotherapy and immunoradiotherapy in the management of head and neck cancer (Review)

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