Combination of quaternary ammonia and glutaraldehyde as a disinfectant against enveloped and non-enveloped viruses

Figueroa, Alejandra; Hauck, Rüdiger; Saldias-Rodriguez, J.; Gallardo, Rodrigo A.

doi:10.3382/japr/pfx021

Cited by 13 publications

(12 citation statements)

References 18 publications

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“…It is essential to highlight that H5N1 avian influenza shares an enveloped structure that conserves stability against different chemical and environmental conditions. 55 , 56 Thus, illustrating similar trends of viral behavior such as SARS-CoV-2. Therefore, considering that the H5N1 highly pathologic pandemic strain was inactivated using our nano-formulation, we can firmly state that our decontamination process will give confidence in an appropriate safety margin for sufficient SARS-CoV-2 inactivation and additional benefits of disinfecting other viral pathogens.…”

Section: Resultsmentioning

confidence: 78%

Promotion of Surgical Masks Antimicrobial Activity by Disinfection and Impregnation with Disinfectant Silver Nanoparticles

Valdez‐Salas

Beltrán-Partida

Cheng³

et al. 2021

IJN

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Background The COVID-19 pandemic is requesting highly effective protective personnel equipment, mainly for healthcare professionals. However, the current demand has exceeded the supply chain and, consequently, shortage of essential medical materials, such as surgical masks. Due to these alarming limitations, it is crucial to develop effective means of disinfection, reusing, and thereby applying antimicrobial shielding protection to the clinical supplies. Purpose Therefore, in this work, we developed a novel, economical, and straightforward approach to promote antimicrobial activity to surgical masks by impregnating silver nanoparticles (AgNPs). Methods Our strategy consisted of fabricating a new alcohol disinfectant formulation combining special surfactants and AgNPs, which is demonstrated to be extensively effective against a broad number of microbial surrogates of SARS-CoV-2. Results The present nano-formula reported a superior microbial reduction of 99.999% against a wide number of microorganisms. Furthermore, the enveloped H5N1 virus was wholly inactivated after 15 min of disinfection. Far more attractive, the current method for reusing surgical masks did not show outcomes of detrimental amendments, suggesting that the protocol does not alter the filtration effectiveness. Conclusion The nano-disinfectant provides a valuable strategy for effective decontamination, reuse, and even antimicrobial promotion to surgical masks for frontline clinical personnel.

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Section: Resultsmentioning

confidence: 78%

Promotion of Surgical Masks Antimicrobial Activity by Disinfection and Impregnation with Disinfectant Silver Nanoparticles

Valdez‐Salas

Beltrán-Partida

Cheng³

et al. 2021

IJN

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“…Glutaraldehyde was also effective in completely inactivating H5N1 subtype AIV reference viruses (Wanaratana et al, 2010). Therefore, the combination of benzalkonium bromide and glutaraldehyde, even at low concentrations, would be a good disinfectant selection to kill enveloped and non-enveloped viruses within field conditions of poultry farms and LPMs (Figueroa et al, 2017). Our data indicated that glutaral and benzalkonium bromide solution under the concentrations of 0.05% for 10 min can completely kill H7N9 AIV.…”

Section: Inactivation Efficacy Of Peroxyacetic Acid Solution Againstmentioning

confidence: 67%

Evaluation of the Viricidal Efficacy of Four Chemical Disinfectants against Emerged H7N9 Avian Influenza Virus in China

Peng

Chen

Miao

et al. 2020

IJAR

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Background: Establishment of scientific disinfection measures in domestic poultry farms and live-poultry markets (LPMs) are critical to prevent the spread of H7N9 subtype avian influenza that outbreaks in poultry and infection in humans. The current study was aimed to evaluate the efficacy of four common disinfectants to inactivate H7N9 subtype avian influenza virus (AIV). Methods: According to the disinfection technical specification, the average inactivation logarithmic values of four disinfectants against the epidemic H7N9 subtype AIV, including deciquam solution, glutaral and benzalkonium bromide solution, sodium dichloroisocyanurate powder, and peroxyacetic acid solution, were systematically evaluated. Result: Our data showed that incubation of 0.005% (w/v) deciquam solution for 30 min contact time, or 0.05% (v/v) glutaral and benzalkonium bromide solution for 10 min, or 0.24 g/L sodium dichloroisocyanurate powder for 30 min, or 0.05% (v/v) peroxyacetic acid solution for 10 min, can completely inactivate H7N9 subtype AIV. These results suggested that glutaral and benzalkonium bromide solution as well as peroxyacetic acid solution at recommended concentrations can be effectively used to cut off the spread of H7N9 subtype AIV in poultry farms and LPMs, however, deciquam solution and sodium dichloroisocyanurate powder need to increase their working concentration.

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“…Recently, the efficacy of QACs and other disinfectants was evaluated on Foc TR4 in the presence of soil (0.05 g·mL −1 ), showing 100% biocidal efficacy at the exposure times evaluated from 30 s to 24 h, as a concentration of 1200 ppm [ 14 ]. Additionally, the efficacy of GA-based products alone or in combination with QACs against pathogenic microorganisms has also been assessed [ 23 , 33 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Disinfectants against Fusarium oxysporum f. sp. cubense Tropical Race 4 Isolated from La Guajira, Colombia

García

Carmona

Zuluaga

et al. 2021

JoF

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Banana, the main export fruit for Colombia, is threatened by Fusarium wilt (FWB), caused by Fusarium oxysporum f. sp. cubense (Foc), tropical race 4 (TR4). Pathogen containment through disinfecting tools, machinery, shoes, and any means that may carry contaminated soil particles with proper disinfectants is at the forefront of disease management. In this study, the biocide efficacy of 10 commercial quaternary ammonium compounds (QACs) products and one based on glutaraldehyde (GA) were evaluated on both reproductive structures (microconidia and macroconidia) and survival spores (chlamydospores) of Foc TR4 (strain 140038) isolated from La Guajira, Colombia. QACs were evaluated at 1200 ppm and two exposure times: <1 and 15 min in the absence or presence of soil. For GA disinfectant, four different concentrations (500, 800, 1200, and 2000 ppm) were evaluated at both contact times in the presence of soil. In the absence of soil, all QACs showed 100% biocidal efficiency against microconidia, macroconidia, and chlamydospores at both <1 and 15 min. The presence of soil decreased the efficacy of disinfectants, but some of them, such as QAC3_1st, QAC7_4th, and QAC5_4th, showed 98%, 98%, and 100% efficacy against Foc TR4 chlamydospores, respectively, after <1 min of contact time. For instance, the GA-based disinfectant was able to eliminate all Foc TR4 propagules after 15 min for all concentrations tested.

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Combination of quaternary ammonia and glutaraldehyde as a disinfectant against enveloped and non-enveloped viruses

Cited by 13 publications

References 18 publications

Promotion of Surgical Masks Antimicrobial Activity by Disinfection and Impregnation with Disinfectant Silver Nanoparticles

Promotion of Surgical Masks Antimicrobial Activity by Disinfection and Impregnation with Disinfectant Silver Nanoparticles

Evaluation of the Viricidal Efficacy of Four Chemical Disinfectants against Emerged H7N9 Avian Influenza Virus in China

Efficacy of Disinfectants against Fusarium oxysporum f. sp. cubense Tropical Race 4 Isolated from La Guajira, Colombia

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