Combination of Pseudoephedrine and Emodin Ameliorates LPS-Induced Acute Lung Injury by Regulating Macrophage M1/M2 Polarization Through the VIP/cAMP/PKA Pathway
Abstract:Background: Acute lung injury (ALI) is an acute multifactorial infectious disease induced by trauma, pneumonia, shock, and sepsis. This study aimed to investigate the protective effects of pseudoephedrine and emodin combined treatment in experimental ALI , as well as the mechanisms underlying the regulation of inflammation and pulmonary edema via the VIP /cAMP/PKA pathway.Methods: Wistar rats were divided into a control group, lipopolysaccharide(LPS) group, and a pseudoephedrine + emodin treatment group. Rats … Show more
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