Combination of preoperative tumour markers and lymphovascular invasion with TNM staging as a cost and labour efficient subtyping of colorectal cancer

Yamano, Tomoki; Yamauchi, Shinichi; Igeta, Masataka; Takenaka, Yuya; Song, Jihyung; Kimura, Kei; Yasuhara, Michiko; Babaya, Akihito; Kataoka, Kozo; Beppu, Naohito; Ikeda, Masataka; Tomita, Naohiro; Sugihara, Kenichi

doi:10.1038/s41598-020-66652-z

Cited by 9 publications

(8 citation statements)

References 20 publications

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“…Vascular invasion is a remarkable risk factor of recurrence (OR 2.3 (CI 95%; 1.56 -3.4)). This finding is in line with previous findings indicating vascular invasion as an important factor in determining high-degree risk factors and a favorable treatment strategy if assessed with tumor markers (TM-LVI status) (20,21). T stage and N stage are also considered risk factors with OR 2.27 (CI 95%; 1.14 -4.51) and OR 2.56 (CI 95%; 1.41 -4.62), respectively.…”

Section: Discussionsupporting

confidence: 91%

Risk Factors of Colorectal Cancer Recurrence After Curative Resection Surgery: A Systematic Review and Meta-analysis

Muhar

Alhudawy

Hermansyah

et al. 2022

Rep Radiother Oncol

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Context: According to the World Health Organization, colorectal cancer (CRC) is the third most prevalent cancer globally, with the highest mortality rate after lung cancer. Some studies predicted risk factors provoking CRC recurrence. However, no single study discussed CRC recurrence. Objectives: This study aimed to quantitatively estimate the influence of several risk factors toward early recurrence of CRC. Methods: We utilized four medical databases, including Pubmed, Cochrane, Wiley library, and ScienceDirect, and a range of literature searches between July to October 2020 with output study, odds ratio (OR), and some risk factors. We used PRISMA protocol along with several relevant keywords with NOS method was utilized to assess the quality of the study. Fixed- and randomized effect model were utilized to control each numerical analysis’ bias. Results: We found six studies that compared the risk factor of CRC recurrence after curative resection with curative-intention encompassing a total of 15.457 patients. We found seven risk factors of colorectal cancer recurrence, including vascular invasion (OR 2.3; IK95%: 01.56 - 3.4; P < 0.0001), depth of invasion (T stage) (OR 2.27; IK95%: 1.14 - 4.51; P = 0.02), pre-operative CEA serum (OR 2.24 95 %IK: 1.57 - 3.2; P < 0.0001), post-operative CEA serum (OR 5.97 IK95% : 3.04 - 11.74; P < 0,0001), pre-operative CA19-9 serum (OR 3.03; IK95%: 1.74 - 5.25; P < 0.0001), and regional nodal metastasis (N stage) (OR 2.56; IK95% 1.41 - 4.62; P = 0.002). Conclusions: Risk factors of earlier CRC recurrence were diversely reviewed. The elevation of post-operative CEA serum was assumed as the main factor in this study; however, most of the studied parameters were statistically significant.

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Section: Discussionsupporting

confidence: 91%

Risk Factors of Colorectal Cancer Recurrence After Curative Resection Surgery: A Systematic Review and Meta-analysis

Muhar

Alhudawy

Hermansyah

et al. 2022

Rep Radiother Oncol

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“…This suggests that simple TNM staging lacks a certain accuracy in predicting the prognosis of intermediate colorectal tumors, and some studies have also proposed the same argument. [36][37][38] For example, A 2020 study evaluated the effect of preoperative tumor markers (TM) combined with LVI (TM-LVI) levels on relapse-free survival at different TNM stages. The c-index and Akaike's information criterion were used to select the best-matched subtypes for predicting relapse-free survival.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Analysis of Lymphovascular Invasion in Stages I–III Colorectal Cancer

Lin

Zheng

Yang

et al. 2023

American Journal of Clinical Oncology

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Introduction: Lymphovascular invasion (LVI) is a micropathological tumor factor believed to increase the risk of tumor metastasis and spread. Propensity score matching (PSM) is a statistical method that can control confounding factors. Current research rarely considers the confounding relationship between LVI and other factors that may influence prognosis. This study aimed to investigate the relationship between LVI and prognosis in patients with stage I–III colorectal cancer (CRC) by using propensity score matching (PSM). Methods: This was a retrospective study involving 610 patients. PSM was used to adjust for baseline differences between the groups. The survival rates were calculated. A nomogram was constructed based on the Cox proportional hazards model before matching. The C-index, receiver operating characteristic curve (ROC), and calibration curve were used to evaluate the nomogram. Results: A total of 150 patients tested positive for LVI, accounting for 24.6% of the total, and 120 couples of patients were identified after PSM. The survival curve and Cox proportional hazards model after matching confirmed the adverse effects of LVI on tumor prognosis. The Cox proportional hazards model before matching showed that age, carcinoembryonic antigen level, T stage, N stage, histologic grade and LVI were independent prognostic factors. The C-index of the nomogram established based on the Cox proportional hazards model was 0.787 (95% CI=0.728–0.845). The areas under the curve were 0.796 in the 3-year ROC. Conclusions: LVI is an adverse prognostic factor in patients with stage I-III colorectal cancer.

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“… Yamagata et al (2021) . reiterated that the presence of LVI was a crucial prognosticator in lymph node-positive breast cancer patients ( Yamano et al, 2020 ). Our study also demonstrated that the DFS and OS of breast cancer patients with LVI were lower in contrast to those without LVI.…”

Section: Discussionmentioning

confidence: 99%

The Systemic Inflammation Response Index as an Independent Predictor of Survival in Breast Cancer Patients: A Retrospective Study

Zhu

Chen

Kong

et al. 2022

Front. Mol. Biosci.

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There is a close relationship between inflammatory cells and tumors, but the pathways that connect the two remain unclear. This research explores the clinical and prognostic value of the systemic inflammation response index (SIRI) in breast cancer patients. The study included 477 breast cancer patients who underwent neoadjuvant chemotherapy and 308 breast cancer patients who did not in our center between January 1998 and December 2016. Optimal SIRI threshold values were determined using the receiver operating characteristic curve (ROC). Patients were then reclassified as SIRI ≥0.80 group (High SIRI group) and SIRI <0.80 group (Low SIRI group). The outcomes were analyzed by statistical methods. The univariate and multivariate analyses demonstrated that SIRI independently predicted survival in breast cancer. The disease-free survival (DFS) and overall survival (OS) in patients with low SIRI scores were significantly longer in contrast to those with high SIRI scores (41.50 vs. 37.63 months, and 64.57 vs. 58.42 months). Further subgroup analyses revealed that low SIRI score patients who also had either early breast cancer, advanced breast cancer, or different molecular subtypes also possessed longer mean survival time of DFS and OS in contrast to those with high SIRI levels (χ2 = 2.379, p = 0.123, and χ2 = 5.153, p = 0.023; χ2 = 11.080, p = 0.0009 and χ2 = 15.900, p < 0.0001; χ2 = 16.020, p < 0.0001 and χ2 = 22.050, p < 0.0001, respectively). SIRI serves as an easily accessible, replicable, and minimally invasive prognostic tool in breast cancer patients. Lower SIRI scores were predictive of a longer DFS and OS after surgery in breast cancer patients. SIRI may serve as a marker to guide clinical management and prognostication of breast cancer.

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Combination of preoperative tumour markers and lymphovascular invasion with TNM staging as a cost and labour efficient subtyping of colorectal cancer

Cited by 9 publications

References 20 publications

Risk Factors of Colorectal Cancer Recurrence After Curative Resection Surgery: A Systematic Review and Meta-analysis

Risk Factors of Colorectal Cancer Recurrence After Curative Resection Surgery: A Systematic Review and Meta-analysis

Prognostic Analysis of Lymphovascular Invasion in Stages I–III Colorectal Cancer

The Systemic Inflammation Response Index as an Independent Predictor of Survival in Breast Cancer Patients: A Retrospective Study

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