Combination of Platelet-Rich Plasma and Hyaluronic Acid vs. Platelet-Rich Plasma Alone for Treatment of Knee Osteoarthritis

Gupta, Ashim; Sharma, Surya Prakash; Potty, Anish G.

doi:10.3390/biomedicines11102759

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…Over the last decade, there has been an increased interest in the use of autologous allografts, including platelet-rich plasma (PRP) for MSK regenerative medicine applications [18]. Numerous studies, including case reports and studies, randomized controlled trials (RCT), systematic reviews, and meta-analyses have demonstrated the safety and efficacy of PRP for MSK disorders [18][19][20][21][22]. Conversely, there are studies demonstrating subpar outcomes [18,23].…”

Section: Introductionmentioning

confidence: 99%

Allogenic Platelet-Rich Plasma for the Treatment of Adhesive Capsulitis

Gupta,

Aratikatla,

Martin

2023

Cureus

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Adhesive capsulitis (AC) is a common shoulder disorder leading to pain and restricted range of motion (ROM) and affects the patient's activities of daily living (ADL) and overall quality of life (QoL). Conservative therapies are prioritized, resorting to surgical intervention only when necessary. Unfortunately, these modalities have limitations and do not address the underlying pathological cause of AC. The use of autologous biologics, such as platelet-rich plasma (PRP), has evolved and shown promise for managing musculoskeletal (MSK) injuries, including AC. However, subpar functional outcomes have led clinicians to question the long-term efficacy of autologous PRP. To circumvent this, the possibility of utilizing a standardized and well-characterized allogenic PRP for AC has been explored. In this manuscript, we qualitatively present in vitro, pre-clinical, clinical, and ongoing studies investigating the varied applications of allogenic PRP for the management of AC. The results demonstrated that allogenic PRP acts in a pleiotropic manner and decreases pro-inflammatory cytokines only in the inflammatory condition. In addition, the administration of allogenic PRP is safe and potentially efficacious, in terms of reducing pain and improving range of motion, shoulder strength, and function, in non-surgical management of AC. Nonetheless, more pre-clinical studies and adequately powered, multicenter, prospective, non-randomized, and randomized controlled trials with longer follow-up are warranted to further establish the safety and efficacy of allogenic PRP and justify its routine clinical use.

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Section: Introductionmentioning

confidence: 99%

Allogenic Platelet-Rich Plasma for the Treatment of Adhesive Capsulitis

Gupta,

Aratikatla,

Martin

2023

Cureus

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confidence: 99%

“…The knee, the most likely joint to present osteoarthritis (OA), is accountable for approximately 80% of the global burden of the OA [1,2]. The prevalence of knee OA has continued to increase over the last two decades, with no indications of slowing down [1,2]. Its etiology entails inflammation of the synovial tissue and degeneration of the articular cartilage, resulting in unendurable pain and loss of function [3,4].…”

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confidence: 99%

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StemOneTM/Stempeucel®: CDSCO Approved, Adult Human Bone Marrow-Derived, Cultured, Pooled, Allogenic Mesenchymal Stem Cells for Knee Osteoarthritis

Gupta

2023

Biomedicines

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A Meta-Analytical Way of Systematizing the Use of Hyaluronan Gels for the Relief of Osteoarthritis, Compared with New Treatment Alternatives

Pinteala,

Maier,

Forna

et al. 2024

Gels

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Hyaluronic acid, in the form of a gel or viscoelastic colloidal solution, is currently used for the viscosupplementation of joints affected by osteoarthritis, but its effectiveness is under debate in relation to newer alternatives. Based on meta-analytical arguments, the present article reinforces the opinion that there are still no decisive arguments for its complete replacement but for its use adapted to the peculiarities of the disease manifestation and of the patients. A “broad” comparison is first made with almost all alternatives studied in the last decade, and then a meta-regression study is performed to compare and predict the effect size induced by viscosupplementation therapy and its main challenger of clinical interest, the platelet-rich plasma treatment. If they are computerized, the developed models can represent tools for clinicians in determining the appropriateness of the option or not for viscosupplementation in a manner adapted to the pain felt by the patients, to their age, or to other clinical circumstances. The models were generated using algorithms implemented in the R language and assembled in different R packages. All primary data and necessary R scripts are provided in accordance with the philosophy of reproducible research. Finally, we adhere in a documented way to the opinion that HA-based products, currently under circumspection, are still clinically useful.

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Combination of Platelet-Rich Plasma and Hyaluronic Acid vs. Platelet-Rich Plasma Alone for Treatment of Knee Osteoarthritis

Abstract: Knee osteoarthritis (OA) is the most documented form of OA and is accountable for about 80% of total OA cases worldwide [...]

Cited by 4 publications

References 9 publications

Allogenic Platelet-Rich Plasma for the Treatment of Adhesive Capsulitis

Allogenic Platelet-Rich Plasma for the Treatment of Adhesive Capsulitis

StemOneTM/Stempeucel®: CDSCO Approved, Adult Human Bone Marrow-Derived, Cultured, Pooled, Allogenic Mesenchymal Stem Cells for Knee Osteoarthritis

A Meta-Analytical Way of Systematizing the Use of Hyaluronan Gels for the Relief of Osteoarthritis, Compared with New Treatment Alternatives

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