Combination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment

Abstract

Cell-based drug delivery systems have shown tremendous advantages in cancer treatment due to their distinctive properties. For instance, delivery of therapeutics using tumor-tropic cells like neutrophils, lymphocytes and mesenchymal stem cells can achieve specific tumor targeting due to the “Trojan Horse” effect. Other circulatory cells like erythrocytes and platelets can greatly improve the circulation time of nanoparticles due to their innate long circulation property. Adipocytes, especially cancer-associated adipocytes, play key roles in tumor development and metabolism, therefore, adipocytes are regarded as promising bio-derived nanoplatforms for anticancer targeted drug delivery. Nanomaterials are important participants in cell-based drug delivery because of their unique physicochemical characteristics. Therefore, the integration of various nanomaterials with different cell types will endow the constructed delivery systems with many attractive properties due to the merits of both. In this review, a number of strategies based on nanomaterial-involved cell-mediated drug delivery systems for cancer treatment will be summarized. This review discusses how nanomaterials can be a benefit to cell-based therapies and how cell-derived carriers overcome the limitations of nanomaterials, which highlights recent advancements and specific biomedical applications based on nanomaterial-mediated, cell-based drug delivery systems.

Versatile carbon nanoplatforms for cancer treatment and diagnosis: strategies, applications and future perspectives

“…Owing to the achievements in nanobiotechnology, application of nanomaterials in cancer theranostics is receiving immense attention 5 - 8 . The combination of nanoplatforms with multiple anticancer agents open a new era for cancer treatment, which largely enhances the therapeutic efficacy while causing reduced adverse effects 9 , 10 . Among a variety of nanomaterials, carbon-based nanostructures stand out as one of the most attractive candidates in cancer theranostics due to their distinct physiochemical properties 11 .…”

Drug Delivery Systems with a “Tumor-Triggered” Targeting or Intracellular Drug Release Property Based on DePEGylation

“…For example, cell membranes are one kind of common “stealthy” coating, due to their functions, such as intercellular communication, bioantifouling, immune defense, etc. [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], including, but not limited to, membranes isolated from erythrocyte [ 15 , 16 ], monocyte [ 17 ], macrophage [ 18 , 19 ], neutrophil [ 20 , 21 ], lymphocyte [ 22 , 23 ], and platelet [ 24 , 25 ], which have been reported to mimic cells for DDS protection [ 10 ]. Similarly, the exosomes or extracellular vesicles derived from cells are also important “stealthy” coatings [ 26 , 27 , 28 ].…”

Combining nanotechnology with the multifunctional roles of neutrophils against cancer and inflammatory disease

“…Neutrophils are the major component of leukocytes in circulation and often serve as the first responders to inflammation during tumorigenesis and infection, indicating their great potential in targeted therapy against cancer and inflammatory disorder. 1,2 Recent decades have witnessed the rapid advancement of nanobiotechnology, which revolutionizes the conventional treatment methods for a wide range of diseases. 3 In this context, numerous functional nanomaterials have been developed to fabricate drug delivery systems (DDSs) to diagnose and treat multiple diseases.…”