Combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran alone

Whole grain benefit: synergistic effect of oat phenolic compounds and β-glucan on hyperlipidemia via gut microbiota in high-fat-diet mice

“…The combination of oat bran and mulberry leaf exhibited a better hypoglycemic role in diabetic mice than oat bran or mulberry leaf alone. 25 In this study, the OPC + OBG group had the strongest capacity to enhance glucose tolerance (Fig. 1D), similar to the effects on body weight and FBG.…”

New insight into the joint significance of dietary jujube polysaccharides and 6-gingerol in antioxidant and antitumor activities

“… 81 Hu et al reported that the combination of mulberry leaf and oat bran enriched in polyphenols and β-glucans could enhance the gut microbiota diversity and regulate their compositions. 82 …”

“…81 Hu et al reported that the combination of mulberry leaf and oat bran enriched in polyphenols and b-glucans could enhance the gut microbiota diversity and regulate their compositions. 82 Nowadays, combined therapy possesses unique advantages compared to monotherapy, which may be due to their synergism, low side effects and dose-limiting toxicity. 83 Recently, Ye et al found that the combination of Lachnum polysaccharide with silymarin could improve the antioxidant status, and protect acute liver injury by suppressing oxidative stress and inammatory response.…”

Hypoglycemic effect of Taraxacum officinale root extract and its synergism with Radix Astragali extract

“…Moreover, the combination of different drugs is considered more effective on treatment of diabetes, which may be due to the complementary role in the mechanism of different biological compounds (Ding et al., 2019; Jiang et al., 2020). It is worth noting that combinations of different drugs in low dose are more common, which can solve the problems of drug dependence, side effects, and tolerance of high dose to some extent (Hu et al., 2019; Sekar et al., 2019). Therefore, the application of natural products in combination can be regarded as a safer and more effective way.…”