Combination of mean platelet volume and the CURB-65 score better predicts 28-day mortality in patients with community-acquired pneumonia

Golcuk, Yalcin; Golcuk, Burcu; Bilge, Adnan; Irik, Mehmet; Dikmen, Onur

doi:10.1016/j.ajem.2015.02.001

Cited by 25 publications

(27 citation statements)

References 31 publications

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“…In another study including patients with community-acquired pneumonia, MPV values have been reported to be significantly different between survivors [9.3±1.2 fl] and non-survivors [8.1±0.6 fl] [6]. Besides the levels of MPV, the authors indicated that CURB-65 (Confusion, Urea, Respiratory rate, Blood pressure, over 65 years of age) score was inversely correlated with MPV, and also, the prediction accuracy of 28-day mortality in patients with community-acquired pneumonia was enhanced by a combination of CURB-65 score and MPV [6].…”

Section: Mpv and Pneumoniamentioning

confidence: 99%

“…Aside from their function in haemostasis, platelets have also a crurical role in the inflammatory response, and also their counts may change in parallel with the severity of infections [1][2][3][4][5][6][7][8][9][10][11]. In addition to changes in platelet counts during infections, platelet sizes can be altered by some factors such as platelet formation from megakaryocytes in response to thrombocytopenia or the release of platelet granules due to the activation of platelets [1][2][3][4].…”

mentioning

confidence: 99%

“…myocardial infarction, ischemic stroke, mesenteric ischemia, deep vein trombosis, decompansated heart failure) or infectious diseases [e.g. sepsis, infective endocarditis, pneumonia, brucellosis, cellulitis, acute pyelonephritis (APN), ascites fluid infection (AFI), hepatitis B or hepatitis C] [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”

mentioning

confidence: 99%

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Could mean platelet volume be a useful marker for infectious diseases? a review of literature

Afyon¹,

Artuk²

2016

Med-Science

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Mean platelet volume (MPV), a parameter of complete blood count analysis, measures the average size of platelets. The alterations of MPV levels have been described as a diagnostic or prognostic predictor in patients with infectious diseases including sepsis, infective endocarditis, pneumonia, brucellosis, cellulitis, acute pyelonephritis, ascites fluid infection, hepatitis B or hepatitis C in recent studies. Although some matters still remain unclear, it can be said that MPV, especially in a scoring system, may be a cost-effective and useful marker for monitoring and predicting outcomes in patients with some infectious diseases in the future.

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Section: Mpv and Pneumoniamentioning

confidence: 99%

mentioning

confidence: 99%

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Could mean platelet volume be a useful marker for infectious diseases? a review of literature

Afyon¹,

Artuk²

2016

Med-Science

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“…There is a negative correlation between progression of liver fibrosis and PLTs (7). In numerous studies, effectiveness of these parameters and indices on predicting outcome of the disease and risk of mortality was investigated (9,10,11,12).…”

Section: Introductionmentioning

confidence: 99%

Red Cell Volume Distribution Width to Platelet Ratio is an Important Predictor of Liver Fibrosis and Cirrhosis in Chronic Hepatitis B

Hakyemez¹,

Bölükçü²,

Durdu³

et al. 2016

vhd

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ÖZObjective: In recent years, a lot of non-invasive tests have been examined for estimating the severity of liver fibrosis in patients with chronic hepatitis B (CHB). We aimed to evaluate the role of simple and valuable platelet-derived indices in estimating the stage of fibrosis and cirrhosis in patients with CHB. Materials and Methods:A total of 434 biopsy-proven naive CHB patients were included in the study. Liver biopsy samples were examined using the ISHAK scoring system. Age, sex, complete blood count parameters and the stage of fibrosis of the patients were recorded. The patients were evaluated according to the severity of fibrosis (stage 0-2: No fibrosis/mild fibrosis and stage 3-6: Significant fibrosis) and the presence of cirrhosis (stage 0-4: No cirrhosis, stage 5-6: Cirrhosis). Results: Of the 434 patients included in the study, 252 (58.1%) were men and 182 (41.9%) were women. The mean age of the patients was 42.7±12.2 years. Significant liver fibrosis was found in 108 (24.9%) patients and cirrhosis in 43 (9.9%) patients. In dual analysis, alterations in many platelet-derived parameters were observed. Receiver operating characteristic curve analysis revealed that red blood cell distribution width to platelet ratio index was the highest area under the curve value (0.777) in predicting significant liver fibrosis and the cutoff value was 0.0814, sensitivity was 56% and specificity was 87%. Conclusion: Platelet-derived indices may play an important role in observing the progression of liver fibrosis and cirrhosis. Platelet ratio index is significantly increased in advanced liver fibrosis in patients with CHB, and can be defined as independent predicting factor in liver fibrosis. Keywords: Chronic hepatitis B, platelet-derived indices, liver fibrosis, cirrhosisAmaç: Son yıllarda, kronik hepatit B (KHB) hastalarında fibrozis şiddetini tahmin etmek için bir çok non-invaziv test çalışılmıştır. Biz basit ve kullanışlı olan platelet kökenli indekslerin kronik hepatit B (KHB) hastalarında fibrozis düzeyi ve siroza gidişte rolünü araştırmayı amaçladık. Gereç ve Yöntemler: Çalışmaya biyopsi ile kanıtlanmış 434 naif KHB hastası dahil edildi. Karaciğer biyopsi örnekleri İSHAK skorlama sistemi kullanılarak incelendi. Yaş, cinsiyet, tam kan sayım parametreleri ve fibrozis evresine ait hasta verileri kaydedilmiştir. Hastalar, fibrozis şiddeti (evre 0-2: Fibrozis yok/hafif ve evre 3-6: Önemli fibrozis) ve siroz varlığı (evre 0-4: Siroz yok, evre 5-6: Siroz) açısından değerlendirilmiştir. Bulgular: Çalışmaya dahil edilen 434 hastanın, 252'si (%58,1) erkek, 182'si (%41,9) kadındı. Hastaların yaş ortalaması 42,7±12,2 idi. Hastaların 108'inde (%24,9) önemli karaciğer fibrozisi, 43'ünde (%9,9) siroz saptandı. İkili analizlerde platelet temelli birçok parametrede anlamlı değişkenlikler saptanmıştır. Alıcı işletim karakteristiği analizi ile yaptığımız değerlendirmede eritrosit dağılım genişliği/ trombosit indeksini önemli karaciğer fibrozisini öngörmede en yüksek eğri altında kalan alan değeri (0,777) olarak saptadık...

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“…Platelets also have an important role in the inflammatory response, apart from their function in haemostasis. Their counts or sizes may change in parallel with the severity of infections, including primary viral hepatitis [3][4][5][6][7][8][9][10][11]. Furthermore, fibrosis severity in patients with hepatitis is another factor influencing platelet counts and indices [3][4][5][6][7].…”

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confidence: 99%

Evaluation of Platelet Indices in Young Male Patients with Hepatitis C

Afyon¹

2016

Ann Clin Anal Med

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ÖzetAmaç: Hepatit C virüs (HCV) enfeksiyonu olan hastalarda enflamasyon ve fibrozisin şiddetine bağlı olarak platelet sayısı ve boyutlarının değişebileceği gerçeği doğrultusunda, HCV enfeksiyonu olan erkek hastalarda sağlıklı kontrol grubuna kıyasla platelet parametrelerinin ve platelet-lenfosit oranı (PLR) seviyelerini ve önemini araştırmayı amaçladık. Gereç ve Yöntem: 01 Ocak 2012 ve 01 Haziran 2015 tarihleri arasında Enfeksiyon Hastalıkları polikliniğine HCV enfeksiyonu nedeniyle müracaat eden hastaların dosyaları geriye dönük olarak değerlendirildi. Karaciğer biyopsisi olmuş 21 erkek hasta ile cinsiyet ve yaş uyumlu 22 sağlıklı kontrol çalışmaya dahil edildi. İsta-tiksel analizler SPSS 15.0 programı ile yapıldı. Bulgular: Hasta grubu (ortalama yaş=24.62±5.84 yıl ve yaş aralığı=21-41 yıl) ve kontrol grubu (ortalama yaş=24.59±5.21 yıl ve yaş aralığı=21-41 yıl) arasında yaş değişkeni açısından anlamlı farklılık yoktu. Hastaların %23.8'inde fibrozis skoru 1, %61.9'unda fibrozis skoru 2 ve sadece %14.3'ünde fibrozis skoru 3 olarak belirlendi. Kontrol grubuna göre hasta grubunda, lenfosit sayıları, platelet sayıları, PLR, plateletcrit ve platelet hacmi dağılım genişliği düşük ve ortalama platelet hacmi (MPV) daha yüksek olsa da, iki grup arasında istatiksel olarak anlamlı farklı-lık yoktu. Ayrıca, platelet sayıları, platelet parametreleri ve PLR değerleri açı-sından fibrozis skoruna ve histolojik aktivite indeksi skoruna göre hasta grupları arasında da anlamlı farklılık yoktu. Tartışma: Çalışmamız sonucunda HCV enfeksiyonuna bağlı minimal ve orta derecede fibrozisi olan genç yetişkin erkek hastalarda, platelet sayıları, platelet parametreleri ve PLR değerlerinde anlamlı olmayan minimal bir etkilenme tespit edildi. Bununla birlikte, platelet sayılarının daha düşük beklendiği ilerlemiş fibrozisi veya sirozu olan hastalarda, platelet parametrelerinin önemi artabilir. Anahtar KelimelerHepatit C Virüsü; Fibrozis; Platelet Parametreleri; Ortalama Platelet Hacmi; Platelet-Lenfosit Oranı Abstract Aim: In light of the fact that platelet counts and sizes or lymphocyte counts may be altered in patients with hepatitis C virus (HCV) depending upon the severity of inflammation or fibrosis, we aimed to investigate the values and the roles of platelet indices and platelet-to-lymphocyte ratio (PLR) in male patients with HCV infection compared with healthy controls. Material and Method: Patients with HCV infection who applied to an Infectious Diseases clinic between 01 January 2012 and 01 June 2015 were evaluated retrospectively. Overall, 21 male HCV patients who underwent percutaneous liver biopsy and 22 gender-and age-matched healthy controls were included in the study. Statistical analyses were performed by SPSS 15.0. Results: There was no significant difference in age variable between the patients group with an age range of 21-41 years [22 (Iq=4), 24.62±5.84 years] and the control group with an age range of 21-41 years [22,5 (Iq=5), 24.59±5.21 years].

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Combination of mean platelet volume and the CURB-65 score better predicts 28-day mortality in patients with community-acquired pneumonia

Cited by 25 publications

References 31 publications

Could mean platelet volume be a useful marker for infectious diseases? a review of literature

Could mean platelet volume be a useful marker for infectious diseases? a review of literature

Red Cell Volume Distribution Width to Platelet Ratio is an Important Predictor of Liver Fibrosis and Cirrhosis in Chronic Hepatitis B

Evaluation of Platelet Indices in Young Male Patients with Hepatitis C

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