2010
DOI: 10.1016/j.gep.2010.06.002
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Combination of in silico and in situ hybridisation approaches to identify potential Dll1 associated miRNAs during mouse embryogenesis

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Cited by 17 publications
(16 citation statements)
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“…93 Thus, miR-449 targets a receptor (Notch1) and a ligand (DLL1), allowing the reduction of Notch signaling and lateral inhibition from both interacting cells. Notch inactivation by miR-449 is expected to release transcriptional repression from genes necessary for differentiation; the exact targets and their precise mechanistic role remain obscure.…”
mentioning
confidence: 99%
“…93 Thus, miR-449 targets a receptor (Notch1) and a ligand (DLL1), allowing the reduction of Notch signaling and lateral inhibition from both interacting cells. Notch inactivation by miR-449 is expected to release transcriptional repression from genes necessary for differentiation; the exact targets and their precise mechanistic role remain obscure.…”
mentioning
confidence: 99%
“…The overexpression of the miR-23a-27a-24-2 cluster can induce apoptosis by creating stress on the endoplasmic reticulum (Chhabra et al, 2011). miR-34a, miR-103, miR-107, miR-130a, miR-130b, miR-449a, and miR-449c are partially complementary to the 3'-untranslated regions of gene Dll1, and participate in the regulation of Dll1 expression in the paraxial and the limb mesoderm, the NT and the hindbrain region, and in the cranial ganglia (Hoesel et al, 2010). The overexpression of miR-34a during NT development can result in an NTD by inducing Dll1 downregulation, which leads to a prolonged state of ventral progenitor expression instead of appropriately timed differentiation (Shookhoff and Gallicano, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…For instance, the altered expression of a subset of discrete miRNAs is involved in NTD generation in p532/2 embryos, which subsequently exhibit exencephaly (Hosako et al, 2009). Several miRNAs are expressed during the murine NT development and directly target genes that are important for NT ontogenesis (Hoesel et al, 2010). These studies, therefore, suggest that miRNAs are involved in CNS development, including in NT development.…”
Section: Introductionmentioning
confidence: 93%
“…It is now well established that miRNAs are critical regulators of proliferation, differentiation, and apoptosis during embryogenesis (for review see, (O’Rourke et al, 2006; Yang and Wu, 2006)), however their role in neural tube development has only recently begun to be examined (Chakrabarty et al, 2007; Song and Tuan, 2006; Wienholds et al, 2005). Indeed, in a recent study, several miRNAs were documented to be expressed in the developing murine neural tube and to target genes crucial for neural tube ontogenesis (Hoesel et al, 2010). Moreover, examination of p53 −/− embryos, exhibiting exencephaly, revealed altered expression of a subset of discrete miRNAs implying their involvement in this NTD (Hosako et al, 2009).…”
Section: Introductionmentioning
confidence: 99%