Combination of Immune-Related Network and Subtype-Specific Analysis Define a Three- Gene Panel for Predicting Prognosis of Triple-Negative Breast Cancer
Abstract:Background: Recent breakthroughs in immune checkpoint inhibitors (ICIs) have shown promise in triple-negative breast cancer (TNBC). Due to the intrinsic heterogeneity among TNBC, clinical response to ICIs varies greatly among individuals. Thus, discovering rational biomarkers to select susceptible patients for ICIs treatment is warranted.Methods: A total of 422 TNBC patients derived from The Cancer Genome Atlas (TCGA) database and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) dataset … Show more
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