2019
DOI: 10.1002/hon.11_2629
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COMBINATION OF IBRUTINIB WITH RITUXIMAB (IR) IS HIGHLY EFFECTIVE IN PREVIOUSLY UNTREATED ELDERLY (>65 YEARS) PATIENTS (PTS) WITH MANTLE CELL LYMPHOMA (MCL) – PHASE II TRIAL

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“…Combination of ibrutinib with rituximab (IR) was also explored in relapsed MCL. Jain et al 33 conducted the first single-center phase II clinical trial to analyze the efficacy and safety of IR combination as the first-line treatment for elderly MCL patients. With a median age of 71 years old, eastern cooperative oncology group (ECOG) performance score of 0–1 in 98% of the cohort, and a median number of IR cycles of 19, the best ORR was 95% (69% CR, 26% PR, 5% stable disease).…”
Section: Efficacy Of Novel Agentsmentioning
confidence: 99%
“…Combination of ibrutinib with rituximab (IR) was also explored in relapsed MCL. Jain et al 33 conducted the first single-center phase II clinical trial to analyze the efficacy and safety of IR combination as the first-line treatment for elderly MCL patients. With a median age of 71 years old, eastern cooperative oncology group (ECOG) performance score of 0–1 in 98% of the cohort, and a median number of IR cycles of 19, the best ORR was 95% (69% CR, 26% PR, 5% stable disease).…”
Section: Efficacy Of Novel Agentsmentioning
confidence: 99%