Combination of hybrid peptide with biodegradable gelatin hydrogel for controlled release and enhancement of anti-tumor activity in vivo

Gaowa, Arong; Horibe, Tomohisa; Kohno, Masayuki; Sato, Keisuke; Harada, Hiroshi; Hiraoka, Masahiro; Tabata, Yasuhiko; Kawakami, Koji

doi:10.1016/j.jconrel.2013.12.021

Cited by 67 publications

(48 citation statements)

References 33 publications

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“…An CMD-peptide conjugates of CMD-s-s-peptide was prepared through the disulfide bond between CMD and EGFRZR-lytic peptide by Gaowa et al [136,137]. The obtained conjugate could be stimulate-responsive by GSH and release to lytic peptide.…”

Section: Other Polymers Modificationmentioning

confidence: 99%

“…Gelatin, which is usually obtained from collagen, has been extensively explored for its biocompatibility and biodegradation in the last few decades. Recently, the combination of antitumor hybrid peptide with anionic gelation was developed [137]. The electrospinning fabrication technique is emerging in biomedical application such as cancer therapies and wound healing treatments.…”

Section: Other Polymers Modificationmentioning

confidence: 99%

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Design and Modification of Anticancer Peptides

Hu¹,

Chen²,

Zhao³

et al. 2016

Drug Des

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Cancer is a great concern in the public health and development of novel therapeutic agent or strategy become urgently. Anticancer peptides (ACPs) have become promising anticancer drug candidate molecules due to their several extraordinary properties, such as small size, high activity, low immunogenicity, good biocompatibility, diversity of sequence and more modification sites for the functional molecules. However, the low stability and short half-life of peptides are the major barriers for the application. In this review, we focus on the methods of peptide design and modification to improve the stability, half-life time and specificity of ACPs, which including amino acid substitution, cyclization, hybridization, fragmentization, modification of C-and N-terminal of peptide by polymer or targeting molecules, etc.modification of C-and N-terminal of peptide by polymer or targeting molecules, etc. The schematic diagram of major design and modification strategies of ACPs are shown in Figure 1.

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Section: Other Polymers Modificationmentioning

confidence: 99%

Section: Other Polymers Modificationmentioning

confidence: 99%

Design and Modification of Anticancer Peptides

Hu¹,

Chen²,

Zhao³

et al. 2016

Drug Des

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“…In addition, this scaffold we designed is biodegradable, since all components, agarose, and gelatin are biodegraded. [ 34 ] The proliferation of NIH3T3 cells within the AG scaffolds was monitored using the Alamar blue assay where a reduction in absorbance is positively correlated with cell viability and is proportional to cell number. As we expected, both aligned and nonaligned AG scaffold resulted in good cell proliferation similar to that on culture plate, since AG gels are pretty biocompatible.…”

Section: Communicationmentioning

confidence: 99%

Hydrogel with Aligned and Tunable Pore Via “Hot Ice” Template Applies as Bioscaffold

Wei

et al. 2016

Adv Healthcare Materials

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“…To improve the pharmacokinetics of this hybrid peptide and its anti-tumor activity after intravenous (i.v.) injection, we subsequently prepared gelatin hydrogel nanoparticles based on the ionic interactions between anionic gelatin and the cationic peptide, and demonstrated that gelatin hydrogel nanoparticles exhibited a longer circulation time in the blood and higher anti-tumor activity than the free peptide [3]. However, gelatin hydrogel as a carrier system has a low capacity for the encapsulation of biological drugs, because the viscosity of gelatin solutions increases with increasing gelatin concentration and decreasing temperature [4].…”

Section: Introductionmentioning

confidence: 99%