Combination of HBA1, TTR, and SERPINF2 in plasma defines phenotype correlated with severe burn outcome

Onishi, Shozo; Matsumoto, Hisatake; Sugihara, Fuminori; Ebihara, Takeshi; Mizunuma, Hiroshi; Osuka, Akinori; Okuzaki, Daisuke; Ogura, Hiroshi; Oda, Jun

doi:10.1016/j.isci.2023.107271

Cited by 2 publications

(2 citation statements)

References 53 publications

(59 reference statements)

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“…performed a proteomic analysis by mass spectrometry using plasma and identified three proteins (HBA1, TTR, and SERPINF2) strongly associated with the prognosis from 642 proteins. 21 Additionally, a diverse multi‐omics blood atlas was created by the COVID‐19 Multi‐omics Blood Atlas (COMBAT) Consortium during the pandemic, 22 which published comprehensive biomolecular information on COVID‐19. Also, an atlas of compiled databases was created with regard to COVID‐19.…”

Section: Reverse Translational Research To Approach Drug Target Molec...mentioning

confidence: 99%

Analysis of comprehensive biomolecules in critically ill patients via bioinformatics technologies

Matsumoto,

Ogura,

Oda

2024

Acute Medicine & Surgery

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Each patient with a critical illness such as sepsis and severe trauma has a different genetic background, comorbidities, age, and sex. Moreover, pathophysiology changes dynamically over time even in the same patient. Therefore, individualized treatment is necessary to account for heterogeneity in patient backgrounds. Recently, the analysis of comprehensive biomolecular information using clinical specimens has revealed novel molecular pathological classifications called subtypes. In addition, comprehensive biomolecular information using clinical specimens has enabled reverse translational research, which is a data‐driven approach to the identification of drug target molecules. The development of these methods is expected to visualize the heterogeneity of patient backgrounds and lead to personalized therapy.

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Section: Reverse Translational Research To Approach Drug Target Molec...mentioning

confidence: 99%

Analysis of comprehensive biomolecules in critically ill patients via bioinformatics technologies

Matsumoto,

Ogura,

Oda

2024

Acute Medicine & Surgery

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“… 56 In addition, proteomic analysis showed that hemoglobin Subunit α 1(HBA1), Transthyretin (TTR), and Serpin Family F Member 2 (SERPINF2) correlated with mortality outcomes, and are promising markers for the future. 57 These genetic and protein expression information are mainly studies that capture changes in the acute phase and support the immune response that has been discussed above. On the other hand, there are currently no studies on the association with mortality in the late phase, and future studies are expected.…”

Section: Genetic Analysis Of Burn Patientsmentioning

confidence: 99%

Systemic immune response of burns from the acute to chronic phase

Osuka,

Shigeno,

Matsuura

et al. 2024

Acute Medicine & Surgery

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Immune responses that occur following burn injury comprise a series of reactions that are activated in response to damaged autologous tissues, followed by removal of damaged tissues and foreign pathogens such as invading bacteria, and tissue repair. These immune responses are considered to be programmed in living organisms. Developments of modern medicine have led to the saving of burned patients who could not be cured previously; however, the programmed response is no longer able to keep up, and various problems have arisen. This paper describes the mechanism of immune response specific to burn injury and the emerging concept of persistent inflammation, immunosuppression, and catabolism syndrome.

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Combination of HBA1, TTR, and SERPINF2 in plasma defines phenotype correlated with severe burn outcome

Cited by 2 publications

References 53 publications

Analysis of comprehensive biomolecules in critically ill patients via bioinformatics technologies

Analysis of comprehensive biomolecules in critically ill patients via bioinformatics technologies

Systemic immune response of burns from the acute to chronic phase

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