Combination of GATA3, SOX-10, and PAX8 in a Comprehensive Panel to Diagnose Breast Cancer Metastases

Na, Kiyong; Woo, Ha Young; Im, Sung Il; Kim, So‐Woon

doi:10.21873/invivo.12727

Cited by 4 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Still, given that either GATA3 or mammaglobin fail to identify more than 50% of TNBCs these markers should be supplemented with markers speci c for TNBC, such as Sry-related HMG box (SOX) 10, which is found in 40%-70% of TNBCs and appears to be expressed in tumors that are negative for GATA3 [32][33][34]. More recently, it was demonstrated that adding SOX10 improved the sensitivity of the markers in metastatic breast cancer (sensitivity = 0.89), metastatic TNBC (0.78), and primary TNBC (0.78) [35]. Another study found that 95% of metastatic breast tumors were positive for GATA3 or SOX10 con rming SOX10's role in identifying TNBC tumors [36].…”

Section: Discussionmentioning

confidence: 99%

Characterization of GATA3 and Mammaglobin in breast tumors from African American women

Ricks-Santi

Fredenburg

Rajaei

et al. 2023

Preprint

View full text Add to dashboard Cite

GATA3 and Mammaglobin are often used in the clinic to identify metastases of mammary origin due to their robust and diffuse expression in mammary tissue. However, the expression of these markers has not been well characterized in tumors from African American women. The goal of this study was to characterize and evaluate the expression of GATA3 and mammaglobin breast tumors from African American women and determine their association with clinicopathological outcomes including breast cancer subtypes. Tissue microarrays (TMAs) were constructed from well preserved, morphologically representative tumors in archived formalin-fixed, paraffin-embedded (FFPE) surgical blocks from 202 patients with primary invasive ductal carcinoma. Mammaglobin, and GATA3 expression was assessed using immunohistochemistry (IHC). Univariate analysis was carried out to determine the association between expression of GATA3, mammaglobin and clinicopathological characteristics. Kaplan-Meier estimates of overall survival and disease-free survival were also plotted and a log-rank test performed to compare estimates among groups. GATA3 expression showed statistically significant association with lower grade (p<0.001), ER-positivity (p<0.001), PR-positivity (p<0.001), and the luminal subtype (p<0.001). Mammaglobin expression was also significantly associated with lower grade (p=0.031), ER-positivity (p=0.007), and PR-positivity (p=0.022). There was no association with recurrence-free or overall survival. Our results confirm that GATA3 and mammaglobin demonstrate expression predominantly in luminal breast cancers from African American women. Markers with improved specificity and sensitivity are warranted given the high prevalence of triple negative breast cancer in the group.

show abstract

Section: Discussionmentioning

confidence: 99%

Characterization of GATA3 and Mammaglobin in breast tumors from African American women

Ricks-Santi

Fredenburg

Rajaei

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Immunohistochemistry. Immunostaining was performed using Bond-III immunostainer (Leica Biosystems, Newcastle-upon-Tyne, UK) (12)(13)(14)(15)(16)(17)(18)(19)). An antigen retrieval was performed using Bond ER2 Solution (Leica Biosystems) for 30 min at 100˚C.…”

Section: Clinicopathological Data Collectionmentioning

confidence: 99%

Gastrointestinal Follicular Lymphoma: A Single-institutional Experience of 22 Cases With Emphasis on the Comprehensive Clinicopathological Analysis and Diagnostic Re-classification

OH,

KIM,

et al. 2023

Anticancer Res

View full text Add to dashboard Cite

Background/Aim: Distinguishing gastrointestinal involvement in classic follicular lymphoma (CFL) and duodenal-type follicular lymphoma (DFL) is crucial for proper treatment. This study aimed to describe an integrated diagnostic re-classification of gastrointestinal follicular lymphoma (GIFL) and identify useful features for its differential diagnosis. Patients and Methods: We reviewed radiological and endoscopic images and pathology slides of 22 GIFL cases, not otherwise specified. Results: Thirteen cases of duodenal grade 1 FL without nodal disease were reclassified as DFL. Five cases of non-duodenal grade 3 FL accompanied by nodal enlargement were re-classified as CFL. The DFL showed peripherally accentuated CD21 immunoreactivity, whereas the CFL showed strong homogeneous CD21 expression. Four atypical cases were reclassified as DFL and CFL in one and three cases, respectively. Conclusion: Our findings support the notion that DFL differs from CFL. In cases of GIFL with atypical features, the possibility of gastrointestinal involvement by CFL should be considered. CD21 expression patterns can assist in the differential diagnosis of CFL and DFL.

show abstract

The Increasing Role of SOX10 in Diagnostic Breast Pathology

Rosa

2022

American Journal of Clinical Pathology

View full text Add to dashboard Cite

Combination of GATA3, SOX-10, and PAX8 in a Comprehensive Panel to Diagnose Breast Cancer Metastases

Cited by 4 publications

References 24 publications

Characterization of GATA3 and Mammaglobin in breast tumors from African American women

Characterization of GATA3 and Mammaglobin in breast tumors from African American women

Gastrointestinal Follicular Lymphoma: A Single-institutional Experience of 22 Cases With Emphasis on the Comprehensive Clinicopathological Analysis and Diagnostic Re-classification

The Increasing Role of SOX10 in Diagnostic Breast Pathology

Contact Info

Product

Resources

About