Combination of fluorescence imaging and local spectrophotometry in fluorescence diagnostics of early cancer of larynx and bronchi

Соколов, В. В.; Филоненко, Е. В.; Telegina, L. V.; Boulgakova, N N; Смирнов, В. В.

doi:10.1070/qe2002v032n11abeh002329

Cited by 17 publications

(10 citation statements)

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“…Using green and red band-pass filters two complementary images are received and ratio between them is calculated to receive more contrast image and to improve sensitivity and specificity of the fluorescent endoscopy approach. [20][21][22][23] One typical problem of exogenous fluorophores' application, for example 5-ALA/PpIX for detection of gastrointestinal tumors is the moderate specificity achieved. High false positive values are obtained, mainly due to inflammation areas in the organs under interest.…”

Section: Resultsmentioning

confidence: 99%

Endogenous and exogenous fluorescence of gastrointestinal tumors: initial clinical observations

Borisova¹,

Plamenova²,

Keremedchiev

et al. 2013

SPIE Proceedings

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The limitations of standard endoscopy for detection and evaluation of cancerous changes in gastrointestinal tract (GIT) are significant challenge and initiate development of new diagnostic modalities. Therefore many spectral and optical techniques are applied recently into the clinical practice for obtaining qualitatively and quantitatively new data from gastrointestinal neoplasia with different level of clinical applicability and diagnostic success. One of the most promising approaches is fluorescence detection using naturally existing fluorescent molecules or added fluorescent markers. Deltaaminolevulinic acid / protoporphyrin IX is applied for exogenous fluorescent tumor detection in the upper part of gastrointestinal tract. The 5-ALA is administered per os six hours before measurements at dose 20mg/kg weight. Highpower light-emitting diode at 405 nm is used as a source and the excitation light is passed through the light-guide of standard video-endoscopic system to obtain 2-D visualization. Both kinds of spectra -autofluorescence signals and protoporphyrin IX signal are recorded and stored using a fiber-optic microspectrometer, as in endoscopy instrumental channel a fiber is applied to return information about fluorescence signals. In such way 1-D detection and 2-D visualization of the lesions' fluorescence are received. The results from in vivo detection show significant differentiation between normal and abnormal tissues in 1-D spectroscopic regime, but only moderate discrimination in 2-D imaging.

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Section: Resultsmentioning

confidence: 99%

Endogenous and exogenous fluorescence of gastrointestinal tumors: initial clinical observations

Borisova¹,

Plamenova²,

Keremedchiev

et al. 2013

SPIE Proceedings

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show abstract

“…Moreover, similar approaches are proposed for differentiation of normal and cancerous sites from other research groups, for gastrointestinal tumors, cancer detection in bronchi and lungs. Using green and red band-pass filters two complimentary images are received and ratio between them is calculated to receive more contrast image and to improve sensitivity and specificity of the fluorescent endoscopy approach (Sokolov, 2002(Sokolov, , 2005Goujon, 2001).…”

Section: Lifs Of Gastrointestinal Tumours -Experimental Resultsmentioning

confidence: 99%

“…Variation of Xillix fluorescent endoscopic system -Xillix-LIFE-GI is applied for autofluorescence detection of stomach neoplasia and has approval for Japan and European countries. Several fluorescent endoscopy systems are developed and proposed also for applications in the practice by different research teams, demonstrating very good clinical results (Chissov, 2003;Papayan, 2006;Sokolov, 2002), using autofluorescence or exogenous fluorescence detection of gastrointestinal neoplasia. Despite of the fluorescent endoscopic systems developed mentioned above, the fluorescent diagnosis of tumors of the upper part of gastrointestinal tract still is very interesting and extensive research and development task worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…On the current moment detecting the difference in autofluorescence as a gastroendoscopic image still has been relatively difficult task because of its faintness. Recent real time gastrointestinal fluorescence endoscopy is all based on the use of exogenous fluorophores (DaCosta, 2003;Sokolov, 2002;Prost, 2002), that increase the contrast, improve endoscopic resolution and sampling, and could be used to receive better 2-D visualization for the needs of clinicians.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Light-Induced Fluorescence Techniques for Gastrointestinal Tumour Detection

Borisova¹,

Vladimirov²,

Ivanova³

et al. 2011

New Techniques in Gastrointestinal Endoscopy

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“…Several fluorescent endoscopy systems are developed and proposed also for practical applications by different research teams, demonstrating very good clinical results [4,[6][7][8], using autofluorescence or exogenous fluorescence detection of gastrointestinal neoplasia.…”

Section: Introductionmentioning

confidence: 99%

5‐ALA Mediated Fluorescence Detection of Gastrointestinal Tumors

Borisova

Vladimirov

Avramov

2008

Advances in Optical Technologies

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Delta-aminolevulinic acid/protoporphyrin IX is applied for fluorescent tumor detection in the upper part of gastrointestinal tract. The 5-ALA is administered per os six hours before measurements at dose 20 mg/kg weight. High-power light-emitting diode at 405 nm is used as an excitation source. Special opto-mechanical device is built to use the light guide of standard video-endoscopic system. Through endoscopic instrumental channel a fiber is applied to return information about fluorescence to microspectrometer. In such way, 1D detection and 2D visualization of the lesions' fluorescence are received, and both advantages and limitations of these methodologies are discussed in relation to their clinical applicability. Comparison of the spectra received from normal mucosa, inflammatory, and tumor areas is applied to evaluate the feasibility for development of simple but effective algorithm based on dimensionless ratio of the fluorescence signals at 560 and 635 nm, for differentiation of normal/abnormal gastrointestinal tissues.

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Combination of fluorescence imaging and local spectrophotometry in fluorescence diagnostics of early cancer of larynx and bronchi

Cited by 17 publications

References 0 publications

Endogenous and exogenous fluorescence of gastrointestinal tumors: initial clinical observations

Endogenous and exogenous fluorescence of gastrointestinal tumors: initial clinical observations

Light-Induced Fluorescence Techniques for Gastrointestinal Tumour Detection

5‐ALA Mediated Fluorescence Detection of Gastrointestinal Tumors

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