Combination of engineered neural cell adhesion molecules and GDF-5 for improved neurite extension in nerve guide concepts

Niere, Marc; Braun, Bettina; Gass, Rea; Sturany, Sabine; Volkmer, Hansjürgen

doi:10.1016/j.biomaterials.2006.01.037

Cited by 15 publications

(20 citation statements)

References 37 publications

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“…Further, a neuroprotective effect of rhGDF‐5 on midbrain dopaminergic neurons in a rat model of Parkonson`s disease has been reported (Sullivan et al 1997. An enhanced neurite outgrowth could be shown (Niere et al 2006). Moreover, it has been reported that rhGDF‐5 is able to induce ectopic bone in muscular tissue, although ectopic bone induction was weak (Kuniyasu et al 2003).…”

Section: Discussionmentioning

confidence: 97%

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Sinus floor augmentation with recombinant human growth and differentiation factor‐5 (rhGDF‐5): a pilot study in the Goettingen miniature pig comparing autogenous bone and rhGDF‐5

Gruber

Ludwig²,

Merten

et al. 2009

Clinical Oral Implants Res

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Section: Discussionmentioning

confidence: 97%

“…There were significant differences between test groups (400 and 800 mg) and control, (400 mg: P ¼ .012, 800 mg: P ¼ .049). (Niere et al 2006). Moreover, it has been reported that rhGDF-5 is able to induce ectopic bone in muscular tissue, although ectopic bone induction was weak (Kuniyasu et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Sinus floor augmentation with recombinant human growth and differentiation factor‐5 (rhGDF‐5): a pilot study in the Goettingen miniature pig comparing autogenous bone and rhGDF‐5

Gruber

Ludwig²,

Merten

et al. 2009

Clinical Oral Implants Res

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show abstract

“…However, some molecules, such as Ephs and netrin1, have been identified as regulators of nigrostriatal pathway development in recent years (Hegarty et al 2013a; Van den Heuvel and Pasterkamp 2008). In an attempt to identify new candidate molecules and signalling pathways that may be involved in nigrostriatal development, this study focused on two BMPs, GDF5 and BMP2, since both of these factors have been implicated in axonal growth in (Parikh et al 2011;Hazen et al 2011Hazen et al , 2012Phan et al 2010;Niere et al 2006;Lein et al 1995;Hegarty et al 2013a) and have been shown to have neurotrophic effects on VM DA neurons, specifically survivaland neurite growth-promoting effects (O'Keeffe et al 2004a;Reiriz et al 1999;Jordan et al 1997;Sullivan et al 1997;Hegarty et al 2014). Despite these studies, the downstream molecular mechanisms that mediate the effects of GDF5 and BMP2 on VM DA neurons are unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The two members of the BMP family of proteins, BMP2 and a related molecule GDF5, have been shown to regulate neurite growth in the dorsal SC (Parikh et al 2011;Hazen et al 2011Hazen et al , 2012Phan et al 2010;Niere et al 2006). GDF5 and BMP2 both activate a canonical signalling pathway involving two types of serine/threonine kinase receptors, type I and type II BMPRs (ten Dijke et al 1994;Koenig et al 1994;Yamashita et al 1996;Shi and Massague 2003).…”

Section: Introductionmentioning

confidence: 99%

Canonical BMP–Smad Signalling Promotes Neurite Growth in Rat Midbrain Dopaminergic Neurons

et al. 2014

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Ventral midbrain (VM) dopaminergic (DA) neurons project to the dorsal striatum via the nigrostriatal pathway to regulate voluntary movements, and their loss leads to the motor dysfunction seen in Parkinson's disease (PD). Despite recent progress in the understanding of VM DA neurogenesis, the factors regulating nigrostriatal pathway development remain largely unknown. The bone morphogenetic protein (BMP) family regulates neurite growth in the developing nervous system and may contribute to nigrostriatal pathway development. Two related members of this family, BMP2 and growth differentiation factor (GDF)5, have neurotrophic effects, including promotion of neurite growth, on cultured VM DA neurons. However, the molecular mechanisms regulating their effects on DA neurons are unknown. By characterising the temporal expression profiles of endogenous BMP receptors (BMPRs) in the developing and adult rat VM and striatum, this study identified BMP2 and GDF5 as potential regulators of nigrostriatal pathway development. Furthermore, through the use of noggin, dorsomorphin and BMPR/Smad plasmids, this study demonstrated that GDF5-and BMP2-induced neurite outgrowth from cultured VM DA neurons is dependent on BMP type I receptor activation of the Smad 1/5/8 signalling pathway.

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“…An ideal strategy for CNS repair relies on promoting regrowth/ sprouting, neuronal survival, synaptogenesis, and remyelination of host axons while stimulating transplanted exogenous neural cells to survive, migrate, and integrate within host tissue [2]. Engineered biomaterials involving specific neural cell adhesion ligands have been recently explored for their ability to support neurite outgrowth and neuronal differentiation relevant for CNS repair [3,4]. However, the effective integration of neuronal bioactivity along with transplantable substrate designs remains a major challenge.…”

Section: Introductionmentioning

confidence: 99%

Oriented, Multimeric Biointerfaces of the L1 Cell Adhesion Molecule: An Approach to Enhance Neuronal and Neural Stem Cell Functions on 2-D and 3-D Polymer Substrates

et al. 2012

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This article focuses on elucidating the key presentation features of neurotrophic ligands at polymer interfaces. Different biointerfacial configurations of the human neural cell adhesion molecule L1 were established on two-dimensional films and three-dimensional fibrous scaffolds of synthetic tyrosine-derived polycarbonate polymers and probed for surface concentrations, microscale organization, and effects on cultured primary neurons and neural stem cells. Underlying polymer substrates were modified with varying combinations of protein A and poly-d-lysine to modulate the immobilization and presentation of the Fc fusion fragment of the extracellular domain of L1 (L1-Fc). When presented as an oriented and multimeric configuration from protein A-pretreated polymers, L1-Fc significantly increased neurite outgrowth of rodent spinal cord neurons and cerebellar neurons as early as 24 h compared to the traditional presentation via adsorption onto surfaces treated with poly-d-lysine. Cultures of human neural progenitor cells screened on the L1-Fc/polymer biointerfaces showed significantly enhanced neuronal differentiation and neuritogenesis on all protein A oriented substrates. Notably, the highest degree of βIII-tubulin expression for cells in 3-D fibrous scaffolds were observed in protein A oriented substrates with PDL pretreatment, suggesting combined effects of cell attachment to polycationic charged substrates with subcellular topography along with L1-mediated adhesion mediating neuronal differentiation. Together, these findings highlight the promise of displays of multimeric neural adhesion ligands via biointerfacially engineered substrates to “cooperatively” enhance neuronal phenotypes on polymers of relevance to tissue engineering.

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Combination of engineered neural cell adhesion molecules and GDF-5 for improved neurite extension in nerve guide concepts

Cited by 15 publications

References 37 publications

Sinus floor augmentation with recombinant human growth and differentiation factor‐5 (rhGDF‐5): a pilot study in the Goettingen miniature pig comparing autogenous bone and rhGDF‐5

Sinus floor augmentation with recombinant human growth and differentiation factor‐5 (rhGDF‐5): a pilot study in the Goettingen miniature pig comparing autogenous bone and rhGDF‐5

Canonical BMP–Smad Signalling Promotes Neurite Growth in Rat Midbrain Dopaminergic Neurons

Oriented, Multimeric Biointerfaces of the L1 Cell Adhesion Molecule: An Approach to Enhance Neuronal and Neural Stem Cell Functions on 2-D and 3-D Polymer Substrates

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