Aim: Currently, regional anesthesia methods are frequently used for post-thoracotomy pain. In this study, we aimed to compare the efficacy of serratus anterior plane block and thoracic epidural block for pain after thoracotomy. Methods: This retrospective study included 120 patients who underwent thoracotomy. Seventy patients who met the inclusion criteria were evaluated in two groups as Group E (thoracic epidural block) (n=37) and Group S (serratus anterior plane block) (n=33). Postoperative 2nd, 6th, 12th and 24 hour visual analogue scale scores and total analgesic consumption for 24 hours were evaluated. Secondary outcomes were determined as side effects, additional analgesic drug requirement and complications. Results: In the comparison between the groups, there were no statistically significant differences between two groups in terms of postoperative 2 nd (p=0.417), 6 th (p=0.271), 12 th (p=0.734) and 24 th hour (p=0.157) visual analogue scale scores and the amount of total analgesic consumption for 24 hours (p=0.714). There was no statistically significant difference between two groups with regard to the side effects nausea and vomiting (p=0.714), pruritus (p=N/A), respiratory depression (p=N/A) levels. Conclusion: The results of this study demonstrate that use of serratus anterior plane block and thoracic epidural block administration has similar outcomes for post-thoracotomy analgesia.