Combination of dasatinib and okadaic acid induces apoptosis and cell cycle arrest by targeting protein phosphatase PP2A in chronic myeloid leukemia cells

Özel, Buket; Kıpçak, Sezgi; Avci, Çığır Biray; Gündüz, Cumhur; Saydam, Güray; Aktan, Çağdaş; Günel, Nur Selvi

doi:10.1007/s12032-021-01643-2

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…The results from phase I and II clinical trials are currently being evaluated for the safety and efficacy of PRI-724, an inhibitor of WNT/β-catenin pathway, in pancreatic cancer and leukaemia patients [ 32 ]. More recently, a combination treatment with dasatinib and okadaic acid (an inhibitor of PP2A) has also been shown to induce cell cycle arrest and apoptosis in the K562 cell line [ 103 ]. However, conflicting reports of the pro- and anti-survival role of PP2A warrants further investigation to understand the situations where such a dual role of PP2A exists [ 104 ].…”

Section: Targeted Therapies Against Bcr::abl1-independent Resistant C...mentioning

confidence: 99%

Mechanisms of Resistance and Implications for Treatment Strategies in Chronic Myeloid Leukaemia

Poudel

Tolland

Hughes

et al. 2022

Cancers

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Tyrosine kinase inhibitors (TKIs) have revolutionised the management of chronic myeloid leukaemia (CML), with the disease now having a five-year survival rate over 80%. The primary focus in the treatment of CML has been on improving the specificity and potency of TKIs to inhibit the activation of the BCR::ABL1 kinase and/or overcoming resistance driven by mutations in the BCR::ABL1 oncogene. However, this approach may be limited in a significant proportion of patients who develop TKI resistance despite the effective inhibition of BCR::ABL1. These patients may require novel therapeutic strategies that target both BCR::ABL1-dependent and BCR::ABL1-independent mechanisms of resistance. The combination treatment strategies that target alternative survival signalling, which may contribute towards BCR::ABL1-independent resistance, could be a successful strategy for eradicating residual leukaemic cells and consequently increasing the response rate in CML patients.

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Section: Targeted Therapies Against Bcr::abl1-independent Resistant C...mentioning

confidence: 99%

Mechanisms of Resistance and Implications for Treatment Strategies in Chronic Myeloid Leukaemia

Poudel

Tolland

Hughes

et al. 2022

Cancers

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“…Among these toxins, okadaic acid (OA) is one of the diarrheal shellsh marine toxins with the most widespread distribution and the highest incidence. OA can cause a series of pathological symptoms by inhibiting protein phosphatase PP1 and PP2A, 1 and changing the intracellular calcium concentration. [2][3][4][5] In addition, OA has been recognized as a potential tumor promoter.…”

Section: Introductionmentioning

confidence: 99%

A 2D carbon nitride-based electrochemical aptasensor with reverse amplification for highly sensitive detection of okadaic acid in shellfish

Chen,

Liu,

Zhu

et al. 2024

Anal. Methods

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“…1 OA was considered as the main cause of diarrhetic shellfish poisoning (DSP) in 1981, causing gastric bowel dysfunction such as nausea, vomiting and diarrhea. 2 OA can inhibit the protein phosphatases PP1, PP2A, and PP2C through stimulating phosphorylation and altering intracellular calcium concentration, 3,4 resulting in pathological symptoms including abdominal pain, nausea, vomiting, and diarrhea. 5,6 In addition, OA possesses potential chronic toxicity including DNA damage, cellular structural damage, 7,8 nervous system [9][10][11] and immune function impairment, 12,13 and embryo development.…”

mentioning

confidence: 99%

2D Carbon Nitride-Based Electrochemical Aptasensor for Label-Free and Highly-Sensitive Detection of Okadaic Acid in Shellfish

Chen¹,

Chen²,

Tian³

et al. 2022

J. Electrochem. Soc.

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Okadaic acid (OA) is a marine toxin accumulated in bivalves causing severe diarrhetic shellfish poisoning, which has become a threat to human health, food safety, and environmental protection. Therefore, it is essential to develop cost-effective and convenient approaches for OA detection. Recent advances in the electrochemical and nanotechniques may provide novel approaches to address this issue. Herein, we developed a label-free electrochemical impedance aptasensor for sensitive detection of OA in shellfish. Two-dimensional carbon nitride conjugated aptamers were employed as the sensitive element for OA detection, which was prepared and characterized by scanning electron microscope and transmission electron microscope. The obtained results indicate this aptasensor exhibited a good performance for the OA detection with a wide linearity ranging from 1×10-14 mol L-1 to 1×10-7 mol L-1. The limit of detection was 1×10-14 mol L-1. In addition, this aptasensor had a good selectivity toward dinophysistoxins, pectenotoxins, and yessotoxin. This aptasensor also showed good reproducibility and stability. Most importantly, the detection with real mussel samples showed good recovery rate. The simple and cost-effective sensing strategy to marine toxins could be applied in the fields of seafood safety and water quality control.

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Combination of dasatinib and okadaic acid induces apoptosis and cell cycle arrest by targeting protein phosphatase PP2A in chronic myeloid leukemia cells

Cited by 6 publications

References 32 publications

Mechanisms of Resistance and Implications for Treatment Strategies in Chronic Myeloid Leukaemia

Mechanisms of Resistance and Implications for Treatment Strategies in Chronic Myeloid Leukaemia

A 2D carbon nitride-based electrochemical aptasensor with reverse amplification for highly sensitive detection of okadaic acid in shellfish

2D Carbon Nitride-Based Electrochemical Aptasensor for Label-Free and Highly-Sensitive Detection of Okadaic Acid in Shellfish

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