Combination of Cp*Rh^III‐Catalyzed C−H Activation and a Wagner–Meerwein‐Type Rearrangement

Abstract

A combination of Cp*Rh -catalyzed C-H activation and Wagner-Meerwein-type rearrangement was successfully achieved for the first time. Thus, bridged polycyclic molecules that are not readily accessible by other means were accessed under mild conditions with high efficiency (as low as 0.5 mol % Rh catalyst) in the coupling of N-phenoxyacetamide with 7-azabenzonorbornadiene.

Rhodium(III)‐Catalyzed Annulation of N‐Methoxybenzamides with Heterobicyclic Alkenes by C–H Functionalization: Synthesis of Benzo[b]phenanthridinones

“…The annulated products were successfully transformed into benzo[ b ]phenanthridinones by a ring‐opening/aromatization sequence. Further, the synthetic protocol was applied to an anti‐HCV agent …”

Chemoselectivity of Pinacol Rearrangement Originate by Different Hexafluoroantimonate Oxidant

“…Crystal samples of 1 and [Ag ·2 2 ] + SbF 6 – in solid‐state were collected by filtration in a nitrogen atmosphere and sealed in tubes. The EPR spectra in Figure display single‐line signals, suggesting that the reaction is most likely based on a radical pathway …”

Cytotoxic and antibacterial polyketide-indole hybrids synthesized from indole-3-carbinol by Daldinia eschscholzii

“…Strategically, the generation of new PIHs usually includes cascade reactions such as C—C(N/O) bond formation 15 and selective functionalization of unactivated aliphatic C( sp 3 )—H bonds 16 . However, these reactions largely proceed in harsh reaction conditions 17 . Thus, the greener approach is highly desired for the access to undescribed PIH molecules, and preferably, the PIH-constructing reactions could be completed in one pot in an eco-friendly manner.…”