Combination of Converting Enzyme Inhibitor With Diuretic for the Treatment of Hypertension

Townsend, Raymond R.; Holland, O. B.

doi:10.1001/archinte.1990.00390180019003

Cited by 76 publications

(28 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8,9 Hydrochlorothiazide (HCTZ) is a thiazide diuretic which is commonly used for the treatment of essential hypertension, at recommended doses of 12.5 mg or 25 mg. 10 In published clinical studies, HCTZ has been shown to act additively in combination with several classes of antihypertensive medication. [11][12][13][14] In addition to its diuretic effect HCTZ is known to activate the renin-angiotensin system. There are therefore theoretical reasons why a combination of HCTZ and an angiotensin II antagonist may offer a highly effective and well-tolerated combination regimen.…”

Section: Introductionmentioning

confidence: 99%

Valsartan and hydrochlorothiazide in patients with essential hypertension. A multiple dose, double-blind, placebo controlled trial comparing combination therapy with monotherapy

et al. 1998

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Valsartan and hydrochlorothiazide in patients with essential hypertension. A multiple dose, double-blind, placebo controlled trial comparing combination therapy with monotherapy

et al. 1998

View full text Add to dashboard Cite

“…In the remaining patients, a synergistic effect upon hypotensive efficacy has been observed when even small doses of diuretics are added. [2][3][4][5] Even though diuretics exert adverse metabolic effects, ACE inhibitors appear to exhibit a neutral or even a beneficial effect on lipid and carbohydrate metabolism, leading to an attenuation of the biochemical sequalae commonly associated with diuretic therapy. [6][7][8][9][10][11] However, indapamide has been reported to induce a moderate change in the serum metabolic parameters.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and metabolic effects of perindopril and diuretics combination in primary hypertension

et al. 1999

View full text Add to dashboard Cite

The effectiveness as well as the metabolic effects of the combination of diuretics [hydrochlorothiazide (HCT) vs indapamide (IND)] and perindopril (P) in 14 patients (7 male, 7 female) aged 37-62 years with mild idiopathic hypertension were studied. Following a 4-week washout period and a 4-week period of monotherapy with P (4 mg/daily), IND (2.5 mg/daily) or HCT (25 mg/daily) was added for 4 weeks. Selection of the diuretic agent was random. Following a 4-week wash-out period from the diuretic, in which only P was given, the alternative diuretic was administered for another period of 4 weeks. P decreased blood pressure levels significantly. However, the drug was more efficacious in patients with higher plasma renin activity (PRA). Combination treatment induced an additional decrease in the blood pressure levels, mainly in patients with lower PRA. The combination of P ؉ HCT was more effective than the combination P ؉ IND. The addition of either HCT or IND

show abstract

“…The relationship between the cost per DDD and the utilized DDD/1000 inh/day provides information of how the utilization of expensive medicines compares with that of less expensive. Other studies have shown that FDC of ACE inhibitor-diuretic achieves therapeutic control and improve the blood pressure in approximately 80 percent of patients [28,29]. The results were proved in multicenter, double-blind, placebocontrolled trial.…”

Section: Fig 4 Changes In Reference Price Per Ddd For the Fdcs Of Amentioning

confidence: 86%

Fixed Doses Combinations Acting on Cardiovascular System - Utilization and Generic Competition

Mitkova

Manova²,

Georgieva

et al. 2016

AIR

View full text Add to dashboard Cite

2 -inhibitors and diuretics, angiotensin receptor blockers (AT receptor blockers, ARBs, sartans) and diuretics. Many new generic molecules as FDCs enter the PDL, thus leading to decrease in the reference price, because of generic competition. The decrease is significant in the new therapeutic groups. The changes in utilization calculated as defined daily dose (DDD)/1000 inhabitants/day show higher utilization in 2013 for the groups of ACE inhibitors and diuretics and AT receptor blockers and diuretics (Enalapril/ Hydrochlorthiazide (HCTZ), Perindopril/ Indapamide, Valsartan/HCTZ, Losartan/ HCTZ). Conclusion:The study confirms that in Bulgaria the generic and therapeutic competition has increased during 2009-2013. It leads to significant price decrease and changes in the trends in utilization of the FDC in cardiology.

show abstract

Combination of Converting Enzyme Inhibitor With Diuretic for the Treatment of Hypertension

Cited by 76 publications

References 111 publications

Valsartan and hydrochlorothiazide in patients with essential hypertension. A multiple dose, double-blind, placebo controlled trial comparing combination therapy with monotherapy

Valsartan and hydrochlorothiazide in patients with essential hypertension. A multiple dose, double-blind, placebo controlled trial comparing combination therapy with monotherapy

Effectiveness and metabolic effects of perindopril and diuretics combination in primary hypertension

Fixed Doses Combinations Acting on Cardiovascular System - Utilization and Generic Competition

Contact Info

Product

Resources

About