Combination of clinical and spectral-CT parameters for predicting lymphovascular and perineural invasion in gastric cancer

A nomogram model of spectral CT quantitative parameters and clinical characteristics predicting lymphovascular invasion of gastric cancer

“…The present study included NLR, PLR, CA19-9, and CA724 and showed that all serological indicators except for CEA were the potential predictors of LVI. Although previous studies suggested a correlation between CEA and LVI in GC patients [ 15 , 17 ], which was inconsistent with our findings, it should be noted that CEA was widely expressed in the body and its level was easily affected by factors other than tumors. Chronic inflammation is implicated to play a critical role in GC development and NLR and PLR are inflammatory indicators [ 21 ].…”

“…Therefore, CA724 level are effective in evaluating the presence of LVI in GC, and was included in the nomogram model. Ren et al proposed that CA125 was an independent factor for LVI in GC [ 15 ], but in our study, it was not included in the nomogram model. Therefore, more comprehensive data and multiple indicators were required to construct the predictive model with the optimal diagnostic efficiency.…”

“…Previous studies have confirmed that spectral CT quantitative parameters exhibit superior advantages and broad prospects in early screening, preoperative staging, and predicting the prognosis of GC [ [11] , [12] , [13] ]. Also, studies have shown that preoperative predictive models including spectral CT are promising to assess LVI in GC patients [ 14 , 15 ]. However, there is no clinical characteristics of tumor [ 14 ] or standardize spectral CT quantitative parameters in their model.…”

Radiomics Analysis to Predict Lymphovascular Invasion of Gastric Cancer Based on Iodine-Based Material Decomposition Images and Virtual Monoenergetic Images

“…In addition, they were unable to prevent a site-by-site bias when placing ROIs in all phases. With an AUC of 0.775, Ren et al 28 indicated that the iodine concentration (IC) exhibits considerable capabilities in the preoperative assessment of LVI. Additional information (such as tumor heterogeneity) was not assessed because the study's IC measurement only took into account the average IC value in ROIs.…”

“…However, most of these factors are confirmed by postoperative pathology diagnosis. Ren et al 28 found that the carbohydrate antigen 125 level, Borrmann type, and tumor histological grade are significantly linked to LVI status. However, no tumor marker in our investigation revealed a significant relationship to LVI status.…”