Combination of Chromium and Biotin Improves Coronary Risk Factors in Hypercholesterolemic Type 2 Diabetes Mellitus: A Placebo‐Controlled, Double‐Blind Randomized Clinical Trial

Abstract

Dyslipidemia, often found in type 2 diabetes mellitus (T2DM) patients, plays an important role in the progression of cardiometabolic syndrome. Two essential nutrients, chromium and biotin, may maintain optimal glycemic control. The authors report here a randomized, double-blind placebo-controlled trial (N=348; chromium picolinate and biotin combination [CPB]: 226, placebo: 122; T2DM participants with hemoglobin A1c [HbA1c] >or=7%) evaluating the effects of CPB on lipid and lipoprotein levels. Participants were randomly assigned (2:1 ratio) to receive either CPB (600 microg chromium as chromium picolinate and 2 mg biotin) or a matching placebo once daily for 90 days. Statistical analyses were conducted in all eligible participants. Subsequent supplemental analyses were performed in T2DM participants with hypercholesterolemia (HC) and in those using stable doses of statins. In the primary analysis, CPB lowered HbA1c (P<.05) and glucose (P<.02) significantly compared with the placebo group. No significant changes were observed in other lipid levels. In participants with HC and T2DM, significant changes in total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and atherogenic index were observed in the CPB group (P<.05). Significant decreases in LDL-C, total cholesterol, HbA1c , and very low-density cholesterol levels (P<.05) were observed in the CPB group taking statins. CPB treatment was well tolerated with no adverse effects, dissimilar from those associated with placebo. These data suggest that intervention with CPB improves cardiometabolic risk factors.

Effects of multivitamin and mineral supplementation on adiposity, energy expenditure and lipid profiles in obese Chinese women

“…Many in vitro studies and studies in the general population have shown that vitamins and minerals have important roles in improving lipid and lipoprotein metabolism. [6][7][8][9] To our knowledge, this study is the first to evaluate the effects of multivitamin and mineral supplementation on lipid profile in obese subjects. Previous studies have shown that calcium, 6 chromium and biotin, 7 niacin, 8 folate, vitamins B 6 and B 12 9 could improve lipid metabolism, and that vitamin B1, 28 vitamin B6, 29 vitamin C, 30 calcium, 31 magnesium, 32 and zinc 33 also have important roles in improving hypertension.…”

“…4 Furthermore, obesity is strongly associated with hyperlipemia, one of the important risk factors of cardiovascular disease. 4,5 Previous studies have shown that vitamins and minerals have an important role in energy and blood lipid metabolism [6][7][8][9] through several mechanisms. [10][11][12][13] Obese individuals are more likely to have either lower blood concentrations or lower bioavailability of minerals and/or vitamins.…”

Improved glucose control associated with i.v. chromium administration in two patients receiving enteral nutrition

“…Some studies have found that chromium administration can reduce fasting plasma glucose by 10-38 mg/dL and reduce glycosylated hemoglobin (hemoglobin A 1c ) by approximately 1%. [4][5][6][7][8][9][10][11][12][13] However, other studies have found no significant difference in these values when comparing chromium administration to placebo. [14][15][16][17][18][19][20][21][22][23][24] Variations in response may be attributable to the different forms of chromium studied.…”

Zelfzorginterventies bij patiënten met diabetes mellitus type 2

“…Het HbA 1c was aan het begin van de studie 9,5% en daalde gemiddeld met 0,3 tot 0,5% in de verschillende groepen. Er werden tussen de verschillende groepen geen significante verschillen gevonden (1000 microgram versus placebo: 0,0%; 95%-betrouwbaarheidsinterval (BI): -0, 8). Verder werden er ook geen verschillen gevonden in het gewicht, de bloeddruk of de vetspectrumwaarden.…”