Combination of chondroitin sulfate and hyaluronic acid increases amount of fibroblast, collagen and decreases adhesion of achilles tendon after repair

Yudistira, Andhika; Risantoso, Tjuk; Basunanda, Tresna Angga; Putera, Marvin Anthony

doi:10.1016/j.jajs.2020.06.002

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…The CS seems also to have a synergic effect with the CeO 2 , as the aligned scaffolds doped with both the active components are characterized by the best performance on cell proliferation. In fact, CS is well known as a facilitator of cell adhesion and an enhancer of their proliferation . In particular, CS is reported as able to increase the proliferation of fibroblasts and also collagen density, as it is a type of glycosaminoglican (GAG) that is found abundantly among other GAG in the body .…”

Section: Results and Discussionmentioning

confidence: 99%

“…In fact, CS is well known as a facilitator of cell adhesion and an enhancer of their proliferation. 54 In particular, CS is reported as able to increase the proliferation of fibroblasts and also collagen density, as it is a type of glycosaminoglican (GAG) that is found abundantly among other GAG in the body. 55 On the other hand, CeO 2 proved to improve the cell adhesion and proliferation as a result of its antioxidative properties that act as oxygen buffer.…”

Section: Scaffolds' In Vitro Degradationmentioning

confidence: 99%

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Cerium Oxide and Chondroitin Sulfate Doped Polyurethane Scaffold to Bridge Tendons

Bianchi

Ruggeri

Vigani

et al. 2023

ACS Appl. Mater. Interfaces

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Tendon disorders are common medical conditions, which can be greatly debilitating as they are often accompanied by great pain and inflammation. The techniques used nowadays for the treatment of chronic tendon injuries often involve surgery. However, one critical aspect of this procedure involves the scar tissue, characterized by mechanical properties that vary from healthy tissue, rendering the tendons inclined to reinjury or rupture. Synthetic polymers, such as thermoplastic polyurethane, are of special interest in the tissue engineering field as they allow the production of scaffolds with controlled elastic and mechanical properties, which could guarantee an effective support during the new tissue formation. The aim of this work was the design and the development of tubular nanofibrous scaffolds based on thermoplastic polyurethane and enriched with cerium oxide nanoparticles and chondroitin sulfate. The scaffolds were characterized by remarkable mechanical properties, especially when tubular aligned, reaching values comparable to the ones of the native tendons. A weight loss test was performed, suggesting a degradation in prolonged times. In particular, the scaffolds maintained their morphology and also remarkable mechanical properties after 12 weeks of degradation. The scaffolds promoted the cell adhesion and proliferation, in particular when in aligned conformation. Finally, the systems in vivo did not cause any inflammatory effect, representing interesting platforms for the regeneration of injured tendons.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Scaffolds' In Vitro Degradationmentioning

confidence: 99%