Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system

Zhou, Lin; Wei, Shaohua; Ge, Xuefeng; Zhou, Jiahong; Jiang, Huijun; Li, Fuyou; Shen, Jian

doi:10.1016/j.jphotobiol.2014.04.010

Cited by 101 publications

(53 citation statements)

References 52 publications

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“…In these cases the drugs for photodynamic therapy (PDT) either act also as fluorescent labels for imaging or a multi-functional nanomaterial was prepared by combining different building blocks, including drug molecules and fluorophores. 189 Again, for cellular imaging the fluorescence of HA was exploited, clearly indicating cellular uptake in the cytoplasm of the studied A549 cells. 188 The PDT photosensitizer hypocrellin A (HA) was non-covalently immobilized on the GO surface and it was found that HA/GO was still able to generate singlet oxygen upon illumination.…”

Section: Fluorescently Labelled Carbon Nanoonionsmentioning

confidence: 99%

Carbon nanomaterials: multi-functional agents for biomedical fluorescence and Raman imaging

2015

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Carbon based nanomaterials have emerged over the last few years as important agents for biomedical fluorescence and Raman imaging applications. These spectroscopic techniques utilize either fluorescently labelled carbon nanomaterials or the intrinsic photophysical properties of the carbon nanomaterial. In this review article we present the utilization and performance of several classes of carbon nanomaterials, namely carbon nanotubes, carbon nanohorns, carbon nanoonions, nanodiamonds and different graphene derivatives, which are currently employed for in vitro as well as in vivo imaging in biology and medicine. A variety of different approaches, imaging agents and techniques are examined and the specific properties of the various carbon based imaging agents are discussed. Some theranostic carbon nanomaterials, which combine diagnostic features (i.e. imaging) with cell specific targeting and therapeutic approaches (i.e. drug delivery or photothermal therapy), are also included in this overview.

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Section: Fluorescently Labelled Carbon Nanoonionsmentioning

confidence: 99%

Carbon nanomaterials: multi-functional agents for biomedical fluorescence and Raman imaging

2015

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“…For example, GO has been employed to deliver aromatic drug molecules into cells via π-π stacking interactions [43,44,77]. Functional graphene quantum dots (GQDs) not only delivered the antitumor drug doxorubicin (DOX) into target cells, but can also monitor the cellular uptake and drug release process in real-time without the need of external dyes [45,53,78].…”

Section: Graphene-small Molecule Nanohybridsmentioning

confidence: 99%

“…After that, some functional small molecules were employed to improve the stability and biocompatibility of nanocarriers. For instance, Zhou and co-workers discovered that the activity of Hypocrellin A (a photosensitive anticancer drug) could be enhanced significantly when 7-ethyl-10-hydroxycamptothecin and Hypocrellin A were co-loaded onto the surface of GO when compared with the modification of Hypocrellin A alone [77]. In vitro experimental results also showed that the photodynamic therapy effect has been greatly improved.…”

Section: Graphene-small Molecule Nanohybridsmentioning

confidence: 99%

Recent Advances in the Synthesis of Graphene-Based Nanomaterials for Controlled Drug Delivery

2017

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Abstract:Graphene-based nanomaterials have exhibited wide applications in nanotechnology, materials science, analytical science, and biomedical engineering due to their unique physical and chemical properties. In particular, graphene has been an excellent nanocarrier for drug delivery application because of its two-dimensional structure, large surface area, high stability, good biocompatibility, and easy surface modification. In this review, we present the recent advances in the synthesis and drug delivery application of graphene-based nanomaterials. The modification of graphene and the conjugation of graphene with other materials, such as small molecules, nanoparticles, polymers, and biomacromolecules as functional nanohybrids are introduced. In addition, the controlled drug delivery with the fabricated graphene-based nanomaterials are demonstrated in detail. It is expected that this review will guide the chemical modification of graphene for designing novel functional nanohybrids. It will also promote the potential applications of graphene-based nanomaterials in other biomedical fields, like biosensing and tissue engineering.

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“…In a similar study, Zhou et al showed a synergistic chemo-PDT of cancer by using GO sheets co-loaded with the anti-cancer drug 7-ethyl-10-hydroxycamptothecin (SN-38) and photosensitizer HA and observed signi¯cantly enhanced therapeutic e®ects of the combined therapy. 110 downregulation of the Bcl-2 protein expression. 111 In addition to this, the PPGA nanocomposites showed enhanced photothermal activity in response to NIR irradiation as compared to PPG nanocomposites lacking the AuNPs, thereby making it also an e±cient photothermal agent.…”

Section: Combined Chemo-photodynamic Therapymentioning

confidence: 99%

Graphene-Based Nanomaterials for Theranostic Applications

Roy

Jaiswal

2017

Rep. Adv. Phys. Sci.

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Graphene and graphene-based nanomaterials such as graphene oxide (GO), reduced graphene oxide (rGO) and graphene quantum dots (GQDs) have gained a lot of attention from diverse scienti¯c¯elds for applications in sensing, catalysis, nanoelectronics, material engineering, energy storage and biomedicine due to its unique structural, optical, electrical and mechanical properties. Graphene-based nanomaterials emerge as a novel class of nanomedicine for cancer therapy for several reasons. Firstly, its structural properties like high surface area and aromaticity enables easy loading of hydrophobic drugs. Secondly, presence of oxygen containing functional groups improve its physiological stability and also act as site for biofunctionalization. Thirdly, its optical absorption in the NIR region enable them to act as photoagents for photothermal and photodynamic therapies of cancer, both in vitro and in vivo. Finally, its intrinsic°u orescence property helps in bioimaging of cancer cells. Overall, graphene-based nanomaterials can act as agents for developing multifunctional theranostic platforms for carrying out more e±cient detection and treatment of cancers. This review provides a detailed summary of the di®erent applications of graphene-based nanomaterials in drug delivery, nucleic acid delivery, phototherapy, bioimaging and theranostics.

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Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system

Cited by 101 publications

References 52 publications

Carbon nanomaterials: multi-functional agents for biomedical fluorescence and Raman imaging

Carbon nanomaterials: multi-functional agents for biomedical fluorescence and Raman imaging

Recent Advances in the Synthesis of Graphene-Based Nanomaterials for Controlled Drug Delivery

Graphene-Based Nanomaterials for Theranostic Applications

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