Combination of Chemical and Mechanical Tumor Immunomodulation Using Cavitating Mesoporous Silica Nanoparticles
Taylor R. Ausec,
Lisa L. Carr,
Talaial B. Alina
et al.
Abstract:Combinatorial
methods to repolarize tumor-associated macrophages
from anti-inflammatory to pro-inflammatory phenotypes offer a promising
route for cancer immunotherapy. However, most studies examine biochemical
combinations alone. Therefore, we studied simultaneous chemical and
mechanical stimuli as orthogonal cues for enhanced immunomodulation.
We engineered the surfaces of hydrophobically functionalized mesoporous
silica nanoparticles (F108-hMSNs) to encapsulate the immunomodulator
resiquimod and kill cancer… Show more
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