Combination of baicalein and ethanol-wet-bonding improves dentin bonding durability

Yi, Luyao; Yu, Jianming; Han, Lin; Li, Tingting; Yang, Hongye; Huang, Cui

doi:10.1016/j.jdent.2019.103207

Cited by 17 publications

(11 citation statements)

References 51 publications

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“…On the other hand, with the aim of improving the durability of dentin bonds, Yi et al [ 162 ] investigated the antibacterial effect of baicalein in association with ethanol-wet bonding. To this end, this flavone was dissolved in increasing concentrations of ethanol (0, 0.01%, 0.05%, and 0.1%) to treat 63 healthy human molars.…”

Section: Clinical Investigations Of Natural Compounds Isolated From M...mentioning

confidence: 99%

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

et al. 2022

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Bacterial strains have developed an ability to resist antibiotics via numerous mechanisms. Recently, researchers conducted several studies to identify natural bioactive compounds, particularly secondary metabolites of medicinal plants, such as terpenoids, flavonoids, and phenolic acids, as antibacterial agents. These molecules exert several mechanisms of action at different structural, cellular, and molecular levels, which could make them candidates or lead compounds for developing natural antibiotics. Research findings revealed that these bioactive compounds can inhibit the synthesis of DNA and proteins, block oxidative respiration, increase membrane permeability, and decrease membrane integrity. Furthermore, recent investigations showed that some bacterial strains resist these different mechanisms of antibacterial agents. Researchers demonstrated that this resistance to antibiotics is linked to a microbial cell-to-cell communication system called quorum sensing (QS). Consequently, inhibition of QS or quorum quenching is a promising strategy to not only overcome the resistance problems but also to treat infections. In this respect, various bioactive molecules, including terpenoids, flavonoids, and phenolic acids, exhibit numerous anti-QS mechanisms via the inhibition of auto-inducer releases, sequestration of QS-mediated molecules, and deregulation of QS gene expression. However, clinical applications of these molecules have not been fully covered, which limits their use against infectious diseases. Accordingly, the aim of the present work was to discuss the role of the QS system in bacteria and its involvement in virulence and resistance to antibiotics. In addition, the present review summarizes the most recent and relevant literature pertaining to the anti-quorum sensing of secondary metabolites and its relationship to antibacterial activity.

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Section: Clinical Investigations Of Natural Compounds Isolated From M...mentioning

confidence: 99%

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

et al. 2022

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“…There are other plant extracts included in this systematic review: quercetin (QUE) ( Gotti et al, 2015 ; Yang et al, 2017 ; Ds et al, 2020 ), resveratrol (RSV) ( Porto et al, 2018 ; Peng et al, 2020 ), baicalein (BAI) (J. Li et al, 2018 ; Yi et al, 2019 ), genipin (GEN) ( Al-Ammar et al, 2009 ), hesperidin (HES) ( Islam et al, 2014 ; Ds et al, 2020 ), rutin (RUT) ( Ds et al, 2020 ), and naringin (NAR) ( Ds et al, 2020 ). The molecular formula, mass and number of hydroxyphenyl radicals are listed in Table 3 .…”

Section: Discussionmentioning

confidence: 99%

“…To begin with, the highly-hydroxylated structures make them capable of forming complexes with proteins, especially proline-rich proteins in dental collagen ( Bravo, 1998 ). This fortified crosslinking interaction helps enhance the mechanical strength of dental bonding ( Yang et al, 2017 ; Yi et al, 2019 ; Peng et al, 2020 ). Furthermore, the polyphenolic compounds could coordinate with metal ions and compete with peptidases such as MMPs for the catalytic domain in collagen ( Mazzoni et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Plant Extracts on Dentin Bonding Strength: A Systematic Review and Meta-Analysis

Zhao

Hua

Yan

et al. 2022

Front. Bioeng. Biotechnol.

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Objective: To systematically review in vitro studies that evaluated the effects of plant extracts on dentin bonding strength.Materials and Methods: Six electronic databases (PubMed, Embase, VIP, CNKI, Wanfang and The Cochrane Library) were searched from inception to September 2021 in accordance with the Preferred Reporting Items for Systematic Reviews (PRISMA). In vitro studies that compared the performance of dental adhesives with and without the plant extracts participation were included. The reference lists of the included studies were manually searched. Two researchers carried out study screening, data extraction and risk of bias assessment, independently and in duplicate. Meta-analysis was conducted using Review Manager 5.3.Results: A total of 62 studies were selected for full-text analysis. 25 articles used the plant extracts as primers, while five added the plant extracts into adhesives. The meta-analysis included 14 articles of in vitro studies investigating the effects of different plant extract primers on dentin bonding strength of etch-and-rinse and self-etch adhesives, respectively. The global analysis showed statistically significant difference between dental adhesives with and without plant extract primers. It showed that the immediate bond strength of dental adhesives was improved with the application of plant extract primers.Conclusion: The application of proanthocyanidin (PA) primers have positive effect on the in vitro immediate bonding strength of dental adhesives irrespective of etch-and-rinse or self-etch modes.

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“…The rapid development of the dentin bonding technique has simplified clinical procedures and greatly shortened clinical treatment times ( Van Meerbeek et al, 2020 ). However, clinical failures, such as marginal microleakage, secondary caries, and restoration shedding suggest that resin–dentin bonding has poor durability ( Breschi et al, 2018 ; Yi et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…The reason for this weakness is that the demineralized dentin needs to be kept sufficiently moist to prevent the collagen fibril from collapsing and promote the penetration of the adhesive monomer ( Hammal et al, 2021 ; Kanca 3rd, 1992 ; Tsujimoto et al, 2019 ). However, it is difficult to control the water humidity in clinical operation, and excessive water will interfere with the complete polymerization of the resin ( Yi et al, 2019 ). Moreover, this phenomenon is more serious in etch-and-rinse systems because the etch-and-rinse technique uses an acid etchant to remove the smear layer and form a 5–10 um layer of demineralized dentin.…”

Section: Introductionmentioning

confidence: 99%

Effects of carbodiimide combined with ethanol–wet bonding pretreatment on dentin bonding properties: an in vitro study

You

Chen

et al. 2022

PeerJ

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Purpose This study evaluated the combined effects of Carbodiimide (EDC) and ethanol–wet bonding (EWB) pretreatment on the bond strength and resin–dentin surface. Methods Phosphoric acid-etched dentin specimens were randomly divided into five groups based on the following pretreatments: deionized water (control), EWB, 0.3M EDC in water (EDCw), EDC water solution combined EWB (EDCw + EWB), and 0.3M EDC in ethanol (EDCe). A scanning electron microscope (SEM) was used to observe the morphology of collagen fibrils on the demineralized dentin matrix in each group after pretreatment. The adhesives Prime & Bond NT (PB) (Dentsply De trey, Konstanz, Germany) or Single bond 2 (SB) (3M ESPE, St. Paul, MN, USA) was applied after pretreatments, and a confocal laser scanning microscope (CLSM) was used to evaluate the quality of resin tags. The degree of conversion (DC) of the adhesive was investigated by Fourier transform infrared spectroscopy (ATR-FTIR). The dentin was first bonded with resin and bathed in water at 37 °C for 24 h. Half of them were subjected to 10, 000 cycles in a thermocycler between 5 °C and 55 °C before a microshear bond strength (µSBS) test. The statistical methods were Analysis of Variance (ANOVA) and a Tukey post hoc test at α = 0.05. Results The µSBS was significantly affected by pretreatments (p < 0.001), adhesives (p < 0.001), and aging conditions (p < 0.001) as revealed by the three-way ANOVA. The EDCw, EDCw + EWB, and EDCe groups significantly increased the µSBS; the EDCw + EWB and EDCe groups produced the highest µSBS. In the EDC-containing groups, the SEM showed at the collagen fibrils in the dentin matrix formed a three-dimensional network structure in the tubules after cross-linking into sheets, and the hybrid layer formed thicker resin tags under a CLSM. In the EDC-containing groups, the CLSM observed an increase in the length of resin tags. PB showed a higher DC and bonding strength than SB, and the five pretreatment groups tested did not affect the DC of the two adhesives. Conclusions In etch–and–rinse bonding system, EDC combined with EWB pretreatment can improve the quality of the hybrid layer and enhance the mechanical properties of demineralized dentin matrix. Pretreatment with EDC–ethanol solution may be a new clinically friendly option for enhancing dentin bonding durability.

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Combination of baicalein and ethanol-wet-bonding improves dentin bonding durability

Cited by 17 publications

References 51 publications

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

Effects of Plant Extracts on Dentin Bonding Strength: A Systematic Review and Meta-Analysis

Effects of carbodiimide combined with ethanol–wet bonding pretreatment on dentin bonding properties: an in vitro study

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