Combination of atorvastatin and gemfibrozil plus physical activity: an animal model of statin/fibrate-induced myopathy

Zabihi, Mohsen; Askarian, Fatemeh; Hekmatimoghaddam, Seyedhossein; Vahidi, Firouzeh

doi:10.1080/08990220.2020.1846514

Cited by 1 publication

(2 citation statements)

References 27 publications

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“…The comorbid conditions that could affect the risk of myopathy were identified during the baseline period per ICD‐10 code: alcoholism (K70, G72.1), chronic kidney disease (N18), chronic hepatic failure (K72.1), hypertension (I10‐15), and hypothyroidism (E02, E03), which was adopted from a nested case–control study on DPP‐4 inhibitors' effects on statin‐associated muscular injury 36 . A history of fibrate use was also identified in each patient as it has been associated with increased risk of myopathy 37 . The index date was defined as the date when statin therapy was initiated or the date when metformin was first added to preexisting statin therapy.…”

Section: Methodsmentioning

confidence: 99%

“…36 A history of fibrate use was also identified in each patient as it has been associated with increased risk of myopathy. 37 The index date was defined as the date when statin therapy was initiated or the date when metformin was first added to preexisting statin therapy. The baseline period for comorbidity and comedication was 3 months prior to the index date.…”

Section: Study Medications and Variablesmentioning

confidence: 99%

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Impact of metformin on statin‐associated myopathy risks in dyslipidemia patients

Bak

Moon

et al. 2023

Pharmacology Res & Perspec

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A growing number of patients with metabolic disorders are receiving statin and antidiabetic therapies as comedications. A signal of increased risk of myotoxicity due to potential interactions between antidiabetics and statins has been detected in previous studies. To investigate the effects of metformin on myopathy risks when added to preexisting statin therapy in dyslipidemia patients, we performed a retrospective cohort study using the Korean national health insurance data in statin‐treated dyslipidemia patients with or without concomitant metformin use. We compared the risk of myopathy in statin + metformin users against statin‐only users. Hazard ratios (HRs) and 95% confidence intervals (CIs) have been calculated following propensity score (PS) matching between study groups and subsequent stratification per patient factors. We included 4092 and 8161 patients in PS‐matched statin + metformin and statin‐only groups, respectively. The risk of myopathy decreased when metformin was used together with statins (adjusted HR 0.84; 95% CI 0.71–0.99). In subgroup analyses per individual statin agent and in stratified risk analyses, no specific statin agents or patient factors were associated with statistically significant myopathy risk. This study found that a comedication with metformin was associated with decreased myopathy risk in statin‐treated dyslipidemia patients compared to statin‐only users. Our findings suggest that metformin may provide protective effects on potential muscle toxicities induced by statin therapy.

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Section: Methodsmentioning

confidence: 99%

Section: Study Medications and Variablesmentioning

confidence: 99%