Combination of aneuploidy and high S-phase fraction indicates increased risk of relapse in stage I endometrioid endometrial carcinoma

Patthey, Annika; Boman, Karin; Tavelin, Björn; Lindquist, David; Lundin, Eva; Hultdin, Magnus

doi:10.1080/0284186x.2021.1939146

Cited by 2 publications

(1 citation statement)

References 31 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It should be noted that we evaluated only two types of tumors in a different proportion than the study presented. An increased S‐phase fraction is associated with poorer prognosis in breast cancer 24 and in endometrioid endometrial carcinoma 25 when compared with cases with low rates. Although no long‐term follow‐up studies have been found investigating the prognostic value of S‐phase fraction and other cell cycle parameters in AM and AC, both neoplasms tend to progress aggressively, which may be an aneuploid feature of odontogenic tumors with a high S‐phase fraction.…”

Section: Discussionmentioning

confidence: 99%

DNA content and clinicopathological features aid in distinguishing ameloblastic carcinoma from ameloblastoma

Penafort,

Rocha,

Mariano

et al. 2024

J Oral Pathology Medicine

View full text Add to dashboard Cite

BackgroundAmeloblastoma and ameloblastic carcinoma are epithelial odontogenic tumors that can be morphologically similar. In the present study, we evaluated the DNA content and Ki‐67 index in the two tumors.MethodsThe paraffin blocks of the tumors were selected to obtain sections for the immunohistochemical reactions and preparation of the cell suspension for acquisition in a flow cytometer. The Random Forest package of the R software was used to verify the contribution of each variable to classify lesions into ameloblastoma or ameloblastic carcinoma.ResultsThirty‐two ameloblastoma and five ameloblastic carcinoma were included in the study. In our sample, we did not find statistically significant differences in Ki‐67 labeling rates. A higher fraction of cells in 2c (G1) was correlated with the diagnosis of ameloblastoma, whereas higher rates of 5c‐exceeding rate (5cER) were correlated with ameloblastic carcinoma. The Random Forest model highlighted histopathological findings and parameters of DNA ploidy study as important features for distinguishing ameloblastoma from ameloblastic carcinoma.ConclusionOur findings suggest that the parameters of the DNA ploidy study can be ancillary tools in the classification of ameloblastoma and ameloblastic carcinoma.

show abstract

Section: Discussionmentioning

confidence: 99%

DNA content and clinicopathological features aid in distinguishing ameloblastic carcinoma from ameloblastoma

Penafort,

Rocha,

Mariano

et al. 2024

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

The Value of the Expression of K-Ras and Dna-Status in the Progression of Endometrioid Endometrial Carcinoma in Patients With Early Stages of Tumor Process

Iurchenko¹,

Glushchenko²,

Skachkova³

et al. 2023

Onkologiâ

View full text Add to dashboard Cite

Summary. Aim: evaluation of DNA ploidy and K-RAS oncoprotein expression in endometrioid endometrial carcinoma (EEC) to determine the metastatic potential of patients with an initial stage of the malignant process. Objects and methods: the study was conducted on samples of postoperative material of 54 patients with EEC stage I according to FIGO (average age: 60.4 years; part from 38 to 72 years). Clinical, morphological, immunohistochemical, flow cytometry, and statistical methods were used for the research. Results: retrospective analysis of medical history revealed patients with EEC who developed metastases in regional lymph nodes within 1.8– 36.6 months. On the basis of this, two groups of studies were formed: I — EEC of patients without metastases (n = 34), II — patients with metastases (n = 20). As a result of the evaluation of the clinical and pathological features of EEC, it was established that G1–G2 tumors predominated (79.4%) in patients of the I group, and in 70.6% of cases, not deep invasion of the myometrium was detected. 55.0% of EEC of the II group had a low degree of differentiation with the deep invasion of the myometrium, which was correlated with a high expression of the oncoprotein K-RAS and the proliferation index. Aneuploidy with iDNA ≥ 2.0 was observed in 20.0% of EEC II group. In such regions, a probably higher expression of K-RAS was determined with this indicator in diploid carcinomas of this group. In addition, the term of occurrence of metastases in patients with aneuploidy was probably shorter than in patients of this group with diploid statuses. Conclusions: it was established that the expression of the K-RAS oncoprotein and DNA ploidy in EEC are associated with the course of the tumor process in stage I patients, which makes it possible to verify patients with a high risk of metastasis.

show abstract

Combination of aneuploidy and high S-phase fraction indicates increased risk of relapse in stage I endometrioid endometrial carcinoma

Cited by 2 publications

References 31 publications

DNA content and clinicopathological features aid in distinguishing ameloblastic carcinoma from ameloblastoma

DNA content and clinicopathological features aid in distinguishing ameloblastic carcinoma from ameloblastoma

The Value of the Expression of K-Ras and Dna-Status in the Progression of Endometrioid Endometrial Carcinoma in Patients With Early Stages of Tumor Process

Contact Info

Product

Resources

About