“…Ten were randomized clinical trials [ 11 , 13 , 16 , 18 , 19 , 22 , 23 , 25 , 26 , 29 ], 16 were retrospective cohort studies [ 12 , 14 , 15 , 17 , 20 , 21 , 24 , 27 , 28 , 30–34 , 36 , 37 ], and 1 was a prospective cohort study [ 35 ]. Twelve were conducted in East Asia [ 11 , 13 , 14 , 21–23 , 28 , 31 , 33–36 ], 7 in North America [ 15 , 17–19 , 26 , 29 , 32 ], 5 in Europe [ 16 , 24 , 27 , 30 , 37 ], 2 in Africa [ 20 , 25 ] and 1 in South America [ 12 ]. Five compared benzathine penicillin G (BPG) or penicillin derivative (amoxicillin) monotherapy with a combined therapy [ 11 , 14 , 16 , 26 , 36 ], and 21 compared penicillin with a different drug monotherapy [ 12 , 13 , 15 , 17–19 , 21–25 , 27–35 , 37 ].…”