Combination of alitretinoin and topical 5-fluorouracil in Darier disease

Soenen, A.; Saint‐Jean, M.; Daguzé, J.; Peuvrel, L.; Quéreux, G.; Dréno, Brigitte

doi:10.1016/j.jdcr.2018.09.024

Cited by 7 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…-Vitamin-D3 analogs (calcipotriol and tacalcitol), in most cases however worsening of the skin [45] -5-Fluoruracil (1 % 1 x per day), inconsistent results [46] -Diclofenac gel 3 %, good response in four patients [47,48] -Fusidinic acid [49] -Gentamicin [50] A fundamental problem of topical treatments is that long-term use would be required for sustained results, but in reality application is restricted to limited areas due to increased absorption and for some agents also possible irritation.…”

Section: Topical Treatmentmentioning

confidence: 99%

“…There are also individual case reports on topical treatment with the following substances: –Vitamin‐D3 analogs (calcipotriol and tacalcitol), in most cases however worsening of the skin [45] –5‐Fluoruracil (1 % 1 x per day), inconsistent results [46] –Diclofenac gel 3 %, good response in four patients [47, 48] –Fusidinic acid [49] –Gentamicin [50] …”

Section: Topical Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Darier and Hailey‐Hailey disease: update 2021

Rogner

Lammer

Zink

et al. 2021

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Summary The autosomal‐dominant genodermatoses Darier disease and Hailey‐Hailey disease present special challenges to dermatologists. Despite their similar pathogenesis featuring impaired adhesion of suprabasal keratinocytes as a result of defective ATPases in epidermal calcium channels, the two diseases differ considerably in clinical presentation and therapeutic options. Darier disease is characterized by reddish brown, keratotic papules in seborrheic and intertriginous areas, which may coalesce into extensive lesions. Individuals affected with Hailey‐Hailey disease primarily develop intertriginous papulovesicles and small blisters, which often evolve into erythematous plaques with erosions and painful fissures. Quality of life is significantly reduced because of complaints (itch, burning sensation, pain), body malodor and chronicity. Therapeutic options remain limited. Antiseptics and intermittent topical corticosteroids are a cornerstone of therapy, and systemic anti‐infective treatment is often required in cases of superinfection. Ablative surgical interventions such as dermabrasion and CO2 laser surgery can lead to long‐term remissions in intertriginous Hailey‐Hailey disease, while temporary relief may also be achieved by intralesional injections of botulinum toxin. Of the systemic medications available for Darier disease, acitretin, which is approved for this purpose, has the best supporting evidence. The efficacy of immunosuppressants and immune modulators is inconsistent. Low‐dose naltrexone produces more satisfactory results in Hailey‐Hailey than Darier disease. The present CME article summarizes current knowledge of the two dermatoses, taking recent developments into account.

show abstract

Section: Topical Treatmentmentioning

confidence: 99%

Section: Topical Treatmentmentioning

confidence: 99%

Darier and Hailey‐Hailey disease: update 2021

Rogner

Lammer

Zink

et al. 2021

J Deutsche Derma Gesell

View full text Add to dashboard Cite

show abstract

“…Moreover, antiseptic solutions (such as triclosan and astringents) and topical antibiotics (including fusidic acid and mupirocin) are effective in reducing secondary bacterial colonization and malodor [ 13 ]. Previous studies have shown that 5-fluorouracil, calcineurin inhibitors, and synthetic vitamin D 3 analog are considered as treatment alternatives [ 18 , 19 , 20 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Type 1 Segmental Darier Disease: Case Report and Discussion of the Treatment Options

2020

View full text Add to dashboard Cite

Darier disease is a rare type of autosomal dominant genodermatosis, and it is caused by a mutation in the gene coding for the endoplasmic reticulum membrane calcium pump Ca2+-ATPase type 2, leading to compromised intercellular adhesion. Moreover, this condition is characterized by multiple keratotic greasy papules with a seborrheic distribution and is worsened by heat and sun exposure, sweating, and friction. Occasionally, it may be associated with nail abnormalities and may involve the mucosa. Unilateral segmental Darier disease is a rare variant characterized by unilateral eruption of erythematic keratotic papules not associated with other conditions. Herein, we report a case of type 1 segmental Darier disease. Furthermore, the main characteristics and treatment options are discussed.

show abstract

“…[38][39][40][41][42] Alitretinoin at 30 mg/day was also used in association with 5-FU on a daily basis in a 43-year-old male who achieved complete remission after 4 months. 43 The disease relapsed when the dose was decreased to 20 mg/day, so the patient continued taking 30 mg/day of alitretinoin. Follow up after three and a half years showed no relapse.…”

Section: Oral Treatmentsmentioning

confidence: 99%

Management of Darier disease: A review of the literature and update

Haber¹,

Dib²

2021

IJDVL

View full text Add to dashboard Cite

Darier disease (DD) is a rare type of inherited keratinizing disorder with no definitive therapeutic approach. The objective of this study is to provide a detailed literature review of all the available treatment modalities of Darier disease, including those that are both surgical and non surgical, to compare their efficacies and to propose a novel therapeutic approach. A complete search of the literature for all articles describing the different treatments of Darier disease, with no restrictions on patients’ ages, gender or nationalities, was performed with the use of PubMed. A total of 68 articles were included in the study: 3 prospective studies, 44 case reports/case series and 21 letters/correspondences/clinical images. The treatments described were topical, oral or physical. Retinoids (isotretinoin, tazarotene and adapalene) and fluorouracil were the two most effective topical treatments. Oral retinoids were the most effective oral therapy and were prescribed in the cases of generalized Darier disease. For localized and resistant skin lesions, physical therapies including surgical excision, dermabrasion and CO2 laser ablation were the first line choices. Limitations of this article include the inability to verify the accuracy of the published data, the relatively small sample size, the absence of randomized controlled clinical trials and possible unidentified confounding factors in various studies. In every therapeutic approach to Darier disease, consideration of patient comorbidities, disease distribution, severity and treatment accessibility is essential. Large and randomized clinical trials are necessary for the comparison of the efficacy and the safety of all the treatments of Darier disease and settling a consensus for management.

show abstract

Combination of alitretinoin and topical 5-fluorouracil in Darier disease

Cited by 7 publications

References 11 publications

Darier and Hailey‐Hailey disease: update 2021

Darier and Hailey‐Hailey disease: update 2021

Type 1 Segmental Darier Disease: Case Report and Discussion of the Treatment Options

Management of Darier disease: A review of the literature and update

Contact Info

Product

Resources

About