Combination of alfa blocker with low dose tadalafil in benign prostatic hyperplasia with erecticle dysfunction management

Reddy, S. V. Krishna; Shaik, Ahammad Basha

doi:10.18535/ijmsci/v4i1.12

Cited by 2 publications

(1 citation statement)

References 33 publications

(46 reference statements)

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“…Altered androgen environment and inflammation represent additional pathophysiologic risk factors for BPH, LUTS and ED. 38 Tadalafil is a Phosphodiesterase 5 Inhibitor which is a popular modality for treatment of Erectile Dysfunction. Phosphodiesrerase 5 inhibitors upregulate NO/cGMP activity.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of efficacy of tadalafil and alfuzosin regimens in patients of benign prostate hyperplasia

Das

Singh

Kumar

et al. 2018

Int J Basic Clin Pharmacol

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Histological prevalence of BPH alongwith LUTS was found to be 50% in men aged 50-60 years and of 90% over 80 years was seen. 75% of men above 50 years old had symptoms arising from BPH, and 20-30% of men reaching 80 years old required surgery.BPH being one of the commonest diseases to be managed by Urologists, its aetiology and pathophysiology are still unclear. 1 ABSTRACTBackground: Aim of the study was to compare efficacy of Tadalafil and Alfuzosin regimens in patients of Benign Prostate Hyperplasia. Methods: It was a comparative, prospective, observational, non-invasive, parallel and randomised study conducted at the Outpatient Department of Urology, Rajindra Hospital, Patiala. 60 patients diagnosed with Benign Prostate Hyperplasia along with Lower Urinary Tract Symptoms, out which, 30 patients, consuming Tadalafil and 30 patients consuming Alfuzosin were considered. History regarding the concerned disease and the compliance of treatment was taken. Symptom scores were assessed with the help of International Prostate Symptom Score, Quality of Lifestyle Score and Erectile Dysfunction Score. Physical examination consisting of Focused Neurological Examination along with Digital Rectal Examination were conducted. Parameters like Renal Function Test, Urine analysis, Ultrasound of Prostate and uroflowmetry were also considered.Results: The mean age selected for study was 64 years for Tadalafil and Alfuzosin group. The mean level of IPS Score, Qol Score and ED Score at the first day of inclusion of patients were 23.96±4.49, 4±0.78, and 25.33±4.02 respectively for Tadalafil group and regarding Alfuzosin group they were 25.23±4.84, 3.56±0.81, and 26.1±4.04 respectively. Follow ups were conducted at 15 days, 1 month and 3 months for both the groups which were found to be statistically significant after 3 months and Alfuzosin showed a favourable result. Conclusions: Alfuzosin 10mg given at daily dose was found to have higher efficacy than Tadalafil (5mg).

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Section: Discussionmentioning

confidence: 99%

A comparative study of efficacy of tadalafil and alfuzosin regimens in patients of benign prostate hyperplasia

Das

Singh

Kumar

et al. 2018

Int J Basic Clin Pharmacol

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A COMPARATIVE STUDY OF TADALAFIL & TAMSULOSIN COMBINATION THERAPY VERSUS ALFUZOSIN MONOTHERAPY IN SEXUALLY ACTIVE PATIENTS OF BENIGN PROSTATIC HYPERPLASIA.

Gupta

Chatterjee²,

Pal

2021

ijsr

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BACKGROUND: The patients, suffering from LUTS due to BPH are generally treated with tamsulosin or silodosin .It was found that maximum patients are suffering from sexual dysfunctions while treating with with those drugs. So in this study we want to observe and compare the tamsulosin and tadalal combination with alfuzosin monotherapy. These two regimens were chosen because, as per nding of various previous studies, these two regimens can prevent and as well as treat the sexual adverse effects related to bph and tamsulosin/ silodosin monotherapy MATERIALAND METHODS: In this study 38 patients were given Tamsulosin (0.4mg) & Tadalal (5mg) xed dose combination therapy and 38 patients were given Alfuzosin (10mg). Symptom scores were assessed with the help of International Prostate Symptom Score (IPS Score), Quality of Lifestyle Score (QoL Score) and International index of erectile dysfunction score (IIEF 5). Uroowmetry was done to evaluate the change in Qmax. The evaluation of patients at each group was done at Day 1, 3 month, 6 months. RESULTS: In this study, patients of both regimens experienced a similar kind of signicant improvement of LUTS, maximum urinary ow(qmax) and better quality of life over time. In case of erectile dysfunction, patients of tamsulosin and tadalal combination experienced a rapid improvement, but after 6 months of therapy both groups experienced similar improvement in sexual well being. CONCLUSION: Alfuzosin is more cost effective and has similar efcacy in comparison to tamsulosin & tadalal combination for treating LUTS due to BPH in sexually active male patients.

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Combination of alfa blocker with low dose tadalafil in benign prostatic hyperplasia with erecticle dysfunction management

Cited by 2 publications

References 33 publications

A comparative study of efficacy of tadalafil and alfuzosin regimens in patients of benign prostate hyperplasia

A comparative study of efficacy of tadalafil and alfuzosin regimens in patients of benign prostate hyperplasia

A COMPARATIVE STUDY OF TADALAFIL & TAMSULOSIN COMBINATION THERAPY VERSUS ALFUZOSIN MONOTHERAPY IN SEXUALLY ACTIVE PATIENTS OF BENIGN PROSTATIC HYPERPLASIA.

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