Combination drug therapy using edaravone and Daio-Orengedoku-to
after transient focal ischemia in rats

Kh, Cho; Oh, Jaewon; Jang, Yangsoo; Jw, Jung; Hr, Oh; Park, EK; Kim, Dong-Hyun; Sk, Moon; Jh, Ryu

doi:10.1358/mf.2008.30.6.1241077

Cited by 3 publications

(2 citation statements)

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“…This multifunctional potential holds promise for advancing scientific understanding and technological applications across a diverse range of fields. From environmental remediation and energy conversion to information technology and biomedicine, the ability to tailor MOS nanoparticles with specific functionalities opens doors to innovative solutions that can reshape industries and improve quality of life [50][51][52][53][54][55][56][57][58].…”

Section: Novel Synthesis Approach For Enhanced Nanocrystalsmentioning

confidence: 99%

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Introduction and Advancements in Room Temperature Ferromagnetic Metal Oxide Semiconductors for Enhanced Photocatalytic Performance

Ayyakannu Sundaram,

Govinda raj,

Ethiraj

et al. 2024

Preprint

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Recent developments in the field of room temperature ferromagnetic metal oxide semiconductors (RTFMOS) have shown promising potential for improved photocatalytic performance. This review focuses on the combined study of photocatalytic and ferromagnetic properties at room temperature, with a particular emphasis on metal oxides, such as TiO2, which have emerged as a key area of interest in the domains of magnetism and environmental remediation. Despite extensive research over the years, the precise mechanism behind the interplay of ferromagnetism and photocatalysis in these materials remains incompletely understood. Several critical factors contributing to magnetism have been hinted at, including oxygen vacancies and various metal doping. Numerous reports have demonstrated that these factors play a primary role in room temperature ferromagnetism and photocatalysis in wide-band-gap metal oxides. However, establishing a direct correlation between magnetism, oxygen vacancies, dopant concentration, and photocatalysis has proven challenging. This review aims to provide a comprehensive overview of the recent progress in understanding the magnetism and photocatalytic behaviour of metal oxides. By examining the latest findings, this study sheds light on the potential of RTFMOS as effective photocatalysts, thereby contributing to advancements in environmental remediation and related applications.

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Section: Novel Synthesis Approach For Enhanced Nanocrystalsmentioning

confidence: 99%

“…Tailored Designs: The flexibility of co-doping allows for tailoring MOS properties according to specific requirements, leading to advancements in materials engineering [51][52][53][54].…”

Section: Elevating Visible-light Activity Via Co-doping Of Mosmentioning

confidence: 99%

Introduction and Advancements in Room Temperature Ferromagnetic Metal Oxide Semiconductors for Enhanced Photocatalytic Performance

Ayyakannu Sundaram,

Govinda raj,

Ethiraj

et al. 2024

Preprint

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The Effects of Chunghyul-Dan (A Korean Medicine Herbal Complex) on Cardiovascular and Cerebrovascular Diseases: A Narrative Review

Jung

Kwon

Cho

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Chunghyul-dan (CHD) is a herbal complex containing 80% ethanol extract and is composed of Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex, Gardeniae Fructus, and Rhei Rhizoma. We have published several experimental and clinical research articles on CHD. It has shown antilipidemic, antihypertensive, antiatherosclerotic, and inhibitory effects on ischemic stroke recurrence with clinical safety in the previous studies. The antilipidemic effect of CHD results from 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase and pancreatic lipase-inhibitory activity. The antihypertensive effect likely results from the inhibitory effect on endogenous catecholamine(s) release and harmonization of all components showing the antihypertensive effects. Furthermore, anti-inflammatory and antioxidant effects on endothelial cells are implicated to dictate the antiatherosclerotic effects of CHD. It also showed neuroprotective effects on cerebrovascular and parkinsonian models. These effects of CHD could be helpful for the prevention of the recurrence of ischemic stroke. Therefore, we suggest that CHD could be a promising medication for treating and preventing cerebrovascular and cardiovascular diseases. However, to validate and better understand these findings, well-designed clinical studies are required.

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A Comparative Study on the Neuroprotective Effect of Geopung-Chunghyuldan on In Vitro Oxygen–Glucose Deprivation and In Vivo Permanent Middle Cerebral Artery Occlusion Models

et al. 2023

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Geopung-Chunghyuldan (GCD), which is a mixture of Chunghyuldan (CD), Radix Salviae Miltiorrhizae, Radix Notoginseng, and Borneolum Syntheticum, is used to treat ischemic stroke in traditional Korean medicine. This study aimed to investigate the effects of GCD and CD on ischemic brain damage using in vitro and in vivo stroke models, as well as to elucidate the synergistic effects of GCD against ischemic insult. To study the effect of GCD in an in vitro ischemia model, SH-SY5Y cells were exposed to oxygen–glucose deprivation (OGD). Cell death after 16 h of OGD exposure was measured using the MTT assay and live/dead cell counting methods. An in vivo ischemia mice model was established through permanent middle cerebral artery occlusion (pMCAO). To determine the neuroprotective effect of GCD, it was orally administered immediately and 2 h after pMCAO. The infarct volume was measured through 2,3,5-triphenyltetrazolium chloride staining at 24 h after pMCAO. Compared with the control group, GCD treatment significantly reduced OGD-induced cell death in SH-SY5Y cells; however, CD treatment did not show a significant protective effect. In the pMCAO model, compared with the control group, treatment with GCD and CD significantly and mildly reduced the infarct volume, respectively. Our findings indicate that compared with CD, GCD may allow a more enhanced neuroprotective effect in acute ischemic stroke, indicating a potential synergistic neuroprotective effect. The possibility of GCD as a novel alternative choice for the prevention and treatment of ischemic stroke is suggested.

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Combination drug therapy using edaravone and Daio-Orengedoku-to after transient focal ischemia in rats

Cited by 3 publications

References 0 publications

Introduction and Advancements in Room Temperature Ferromagnetic Metal Oxide Semiconductors for Enhanced Photocatalytic Performance

Introduction and Advancements in Room Temperature Ferromagnetic Metal Oxide Semiconductors for Enhanced Photocatalytic Performance

The Effects of Chunghyul-Dan (A Korean Medicine Herbal Complex) on Cardiovascular and Cerebrovascular Diseases: A Narrative Review

A Comparative Study on the Neuroprotective Effect of Geopung-Chunghyuldan on In Vitro Oxygen–Glucose Deprivation and In Vivo Permanent Middle Cerebral Artery Occlusion Models

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